The American Journal of Digestive Diseases

, Volume 17, Issue 10, pp 945–953 | Cite as

Cyclic AMP and gastric secretion

  • M. Samir Amer
Editorial

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Harris JB, Nigon D, Alonso D: Adenosine-3′,5′-monophosphate: intracellular mediator for methylxanthine stimulation of gastric secretion. Gastroenterology 57:377–384, 1969PubMedGoogle Scholar
  2. 2.
    Scratcherd T, Case RM: The role of cyclic adenosine-3′,5′-monophosphate (cAMP) in gastrointestinal secretion. Gut 10:957–961, 1969PubMedGoogle Scholar
  3. 3.
    Levine RA, Wilson DE: The role of cyclic AMP in gastric secretion. Ann NY Acad Sci 185:363–375, 1971PubMedGoogle Scholar
  4. 4.
    Levine RA: The role of cyclic AMP in hepatic and gastrointestinal function. Gastroenterology 59:280–300, 1970PubMedGoogle Scholar
  5. 5.
    Harris JB, Alonso D: Stimulation of the gastric mucosa by adenosine-3′,5′-monophosphate. Fed Proc 24:1368–1376, 1965PubMedGoogle Scholar
  6. 6.
    Nigon K, Harris JB: Adenosine monophosphate and phosphorylase activity in frog stomachs. Am J Physiol 215:1299–1304, 1968PubMedGoogle Scholar
  7. 7.
    Amer MS, McKinney GR: Studies with cholecystokinin in vitro: IV. Effects of cholecystokinin and related peptides on phosphodiesterase. J Pharmacol Exp Ther (In press)Google Scholar
  8. 8.
    Amer MS: Studies in the phosphodiesterases: I. Identification of two forms of the enzyme in rabbit liver and in other tissues. Biochem J (In press)Google Scholar
  9. 9.
    Johnson LR, Grossman MI: Intestinal hormones as inhibitors of gastric secretion. Gastroenterology 60:120–144, 1971Google Scholar
  10. 10.
    Master SP, Bedi BS, de Sousa AP, et al: Sustained inhibition of gastric secretion by repeated rapid intravenous injections of gastrin. Gastroenterology 56:875–881, 1969PubMedGoogle Scholar
  11. 11.
    Amer MS: Effects of aspirin, other analgesics, histamine and some antihistaminics on 3′,5′-cyclic adenosine monophosphate (cAMP) phosphodiesterase (PDE) activity from rabbit liver. Abstracts APA Acad Pharmaceutical Sciences 1:120, 1971Google Scholar
  12. 12.
    Perrier CV, Laster L: Adenyl cyclase activity of guinea pig gastric mucosa. Clin Res 17:586, 1969Google Scholar
  13. 13.
    Mao CC, Shanbour IL, Hodgins DS, et al: J Lab Clin Med 78:830, 1971Google Scholar
  14. 14.
    Amer MS: Studies with cholecystokinin in vitro. III. Mechanism of the effect on the isolated gall bladder strips. J Pharmacol Exp Ther (In press)Google Scholar
  15. 15.
    Amer MS, Marquis NR: The effect of prostaglandins, epinephrine and aspirin on cyclic AMP phosphodiesterase activity of human blood platelets and their aggregation. Prostaglandins in Cellular Biology. Edited by RW Ramwell, BB Pharris. New York, Plenum Press, 1972, pp 93–106.Google Scholar
  16. 16.
    Salzman EW: Cyclic AMP and platelet function. N Engl J Med 286:358–363, 1972PubMedGoogle Scholar
  17. 17.
    Brooks FP: Report of a symposium on gastrointestinal hormones. Digestive Diseases 15:1045–1046, 1970CrossRefGoogle Scholar
  18. 18.
    Abbott DD, Rossi GV: The relationship of gastrin activity to antral motility: a review. Am J Pharmacy 137:15–23, 1965Google Scholar
  19. 19.
    Robertson CR, Rosiere CE, Blickenstaff D, Grossman MJ: The potentiating action of certain xanthine derivatives on gastric acid secretory responses in the dog. J Pharmacol Exp Ther 99:323–365, 1950Google Scholar
  20. 20.
    Bueding E, Butcher RW, Hawkins J: Effect of epinephrine on cyclic adenosine 3′,5′-phosphate and hexose phosphates in intestinal smooth muscle. Biopys Biochim Acta 115:173–178, 1966Google Scholar
  21. 21.
    Robinson GA, Butcher RW, Sutherland EW: Cyclic AMP. Ann Rev Biochem 37:149–174, 1968CrossRefPubMedGoogle Scholar
  22. 22.
    Kim TS, Shulman J, Levine RA: Relaxant effect of cyclic 3′,5′-AMP on the isolated rabbit ileum. J Pharmacol Exp Ther 163:36–42, 1968PubMedGoogle Scholar
  23. 23.
    Wilkenfeld BE, Levy B: The effects of theophylline, diazoxide and imidazole on isoproterenol-induced inhibition of the rabbit ileum. J Pharmacol Exp Ther 169:61–67, 1969PubMedGoogle Scholar
  24. 24.
    Levine RA, Cafferata EP, McNally EF: Inhibitory effect of adenosine 3′,5′-monophosphate on gastric secretion and gastrointestinal motility in vivo. RecAdv Gastroenterol 1:408–410, 1967Google Scholar
  25. 25.
    Amer MS: Studies with cholecystokinin in vitro: III. Mechanism of the effect on the isolated rabbit gall bladder strips. J Pharmacol Exp Ther (In press)Google Scholar
  26. 26.
    Kawasaki A, Kashimoto T, Yoshida H: Effects of 3′,5′-cyclic adenosine monophosphate and its dibutyryl derivative on the motility of isolated rat ileum. Jap J Pharmacol 19:494–501, 1969PubMedGoogle Scholar
  27. 27.
    Morisset JA, Webster PD: In vitro and in vivo effects of dibutyryl cyclic AMP (DCAMP) on pancreatic amylase secretion and synthesis. Clin Res 18:38, 1970Google Scholar
  28. 28.
    Bennett A, Fleshler B: Prostaglandins and the gastrointestinal tract. Gastroenterology 59:790–800, 1970PubMedGoogle Scholar
  29. 29.
    Butcher RW, Scott RE, Sutherland EW: The effects of prostaglandins on cyclic AMP in tissues. Pharmacologist 9:172, 1967Google Scholar
  30. 30.
    Robert A, Nezamis JE, Phillips JP: Inhibition of gastric secretion by prostaglandins. Am J Dig Dis 12:1073–1076, 1967PubMedGoogle Scholar
  31. 31.
    Way L, Durbin RP: Inhibition of gastric acid secretion in vitro by prostaglandin E1. Nature 221:874–875, 1969PubMedGoogle Scholar
  32. 32.
    Lippmann W: Inhibition of gastric secretion in the rat by synthetic prostaglandins. J Pharm Pharmacol 21:335–336, 1969PubMedGoogle Scholar
  33. 33.
    Classen M, Koch H, Brickhardt J, et al: The effect of prostaglandin E1 on the pentagastrin stimulated gastric secretion in man. Digestion 4:333–344, 1971PubMedGoogle Scholar
  34. 34.
    Lin TM, Spray GF: Effect of glucagon on gastric HCl secretion. Gastroenterology 54:1254, 1968Google Scholar
  35. 35.
    Lin TM, Evans DC, Spray GF, et al: Action of glucagon on histamine-induced gastric acid secretion in dogs and rats. Arch Int Pharmacodyn Ther 188:332–340, 1970PubMedGoogle Scholar
  36. 36.
    Lin TM, Warrick MW: Effect of glucagon on pentagastrin-induced gastric acid secretion and mucosal blood flow in the dog. Gastronenterology 61:328–331, 1971Google Scholar
  37. 37.
    Singleton JW: Humoral effects of the pancreas upon the gastrointestinal tract. Gastroenterology 56:342–362, 1969PubMedGoogle Scholar
  38. 38.
    Kock NG, Darle N, Dotevall G: Inhibition of intestinal motility in man by glucagon given intraperitoneally. Gastroenterology 53:88–92, 1967Google Scholar
  39. 39.
    Nakajima S, Magee DF: Inhibition of exocrine pancreatic secretion by glucagon and D-glucose given intravenously. Canad J Physiol Pharmacol 48:299–305, 1970Google Scholar
  40. 40.
    Dyck WP, Texter EC Jr, Lasater JM, Hoexter B: Influence of glucagon on pancreatic exocrine secretion. Gastroenterology 56:531–537, 1969PubMedGoogle Scholar
  41. 41.
    Dupre J: Regulation of the secretions of the pancrease. Ann Rev Med 21:299–316, 1970CrossRefPubMedGoogle Scholar
  42. 42.
    Case RM, Laundy TJ, Scratcherd T: Adenosine 3',5'-monophosphate (cyclic AMP) as the intracellular mediator of the action of secretin on the exocrine pancreas. J Physiol 204:45–47, 1969Google Scholar
  43. 43.
    Butcher RW, Carlson LA: Effects of secretin on fat mobilizing lipolysis and cyclic AMP levels in rat adipose tissue. Acta Physiol Scand 79:559–563, 1970PubMedGoogle Scholar
  44. 44.
    Johnson LR, Grossman MI: Characteristics of inhibition of gastric secretion by secretin. Am J Physiol 217:1401–1404, 1969PubMedGoogle Scholar
  45. 45.
    Chey WY, Kosay S, Hendricks J, et al: Effect of secretin on motor activity of the stomach and Heidenhain pouch in dogs. Am J Physiol 217:848–852, 1969PubMedGoogle Scholar
  46. 46.
    Cameron AJ, Phillips SF, Summerskill HJ: Comparison of the effects of gastrin, cholecystokinin-pancreozymin, secretin, and glucagon on human stomach muscle in vitro. Gastroenterology 59:539–545, 1970PubMedGoogle Scholar
  47. 47.
    Stening GF, Johnson LR, Grossman MI: Effect of secretin on acid and pepsin secretion in the cat and dog. Gastroenterology 56:468–475, 1969PubMedGoogle Scholar
  48. 48.
    Magee DF, Nakajima S: Stimulatory action of secretin on gastric pepsin secretion. Experientia 24:689–690, 1968CrossRefPubMedGoogle Scholar
  49. 49.
    Weiss B, Costa E: Selective stimulation of adenylcyclase of rat pineal gland by pharmacologically active catecholamines. J Pharmacol Exp Ther 161:310–319, 1968Google Scholar
  50. 50.
    Jacobson ED, Swan KG, Grossman MI: Blood flow and secretion in the stomach. Gastroenterology 52:414–420, 1967PubMedGoogle Scholar
  51. 51.
    Misher A, Pendleton RG, Staples R: Effects of adrenergic drugs upon gastric secretion in rats. Gastroenterology 57:294–299, 1969PubMedGoogle Scholar
  52. 52.
    Amer MS: A possible mechanism for the gastric inhibitory effects of antigastrin. Biochem Pharmacol (In press)Google Scholar
  53. 53.
    Pradhan SN, Wingate HW: Effects of some adrenergic blocking agents on gastric secretion in dogs. Arch Int Pharmacodyn Ther 162:303–310, 1966PubMedGoogle Scholar
  54. 54.
    Anichkov SV, Grechistikin: Influence of catecholamines on pepsinogen production. Arch Int Pharmacodyn Ther 180:281–288, 1969PubMedGoogle Scholar
  55. 55.
    Mansour TE: Effect of hormones on carbohydrate metabolism of invertebrates. Fed Proc 26:1179–1185, 1967PubMedGoogle Scholar
  56. 56.
    Thompson JH: Serotinin and the alimentary tract. Research Comm Chem Pathol Pharmacol 2:687–781, 1971Google Scholar
  57. 57.
    Poch G, Kukovetz WR: Papaverine-induced inhibition of phosphodiesterase activity in various mammalian tissues. Life Sciences 10:133–144, 1971CrossRefGoogle Scholar
  58. 58.
    Markwardt F, Hoffmann A: Effects of papaverine derivatives on cyclic AMP phosphodiesterase of human platelets. Biochem Pharmacol 19:2519–2520, 1970CrossRefPubMedGoogle Scholar
  59. 59.
    Kukovetz WR, Poch G: Inhibition of cyclic-3',5'-nucleotide phosphodiesterase as a possible mode of action of papaverine and similarly acting drugs. Arch Pharmak 267:189–194, 1970Google Scholar
  60. 60.
    Triner L, Vulliemoz Y, Schwartz I, et al: Cyclic phosphodiesterase activity and the action of papaverine. Biochem Biophys Res Comm 90:64–69, 1970CrossRefGoogle Scholar
  61. 61.
    Shanbour LL, Mao CC, Hodgins DS, et al: Gastric secretion and inhibition of phosphodiesterase in the dog. Gastroenterology 60:716, 1971Google Scholar
  62. 62.
    Bromster D, Lindgren E, Rosen A, et al: Effects of papaverine on gastric emptying and gastric secretion in man. Acta Radiol 8:354–364, 1969Google Scholar
  63. 63.
    Blum H, Mutschiller E, van Zwieten PA: Uber den Einfluss von cholinergen Pharmaka auf die Ulcersbildung und die Magensaftsekretion bei der Shay-Ratte. Arch Pharmak Exp Path 256:99–111, 1967Google Scholar
  64. 64.
    Murad F, Chi YM, Rall TW, Sutherland EW: Adenyl cyclase: III. The effect of catecholamines and choline esters on the formation of adenosine 3',5'-phosphate by preparations from cardiac muscle and liver. J Biol Chem 237:1233–1238, 1962PubMedGoogle Scholar
  65. 65.
    Goodman L, Gilman A: The Pharmacological Basis of Therapeutics. Fourth edition. New York, The Macmillan Company, 1970Google Scholar
  66. 66.
    Suano S: The inhibitory action of caffeine on the smooth muscle of the guinea-pigTaenia coli. Experientia 26:969–970, 1970CrossRefPubMedGoogle Scholar
  67. 67.
    Debas HT, Holubitsky MM, Harrison RC: Caffeine-stimulated gastric acid and pepsin secretion: dose response studies. Scand J Gastroenterol 6:453–457, 1971PubMedGoogle Scholar
  68. 68.
    Harris JB, Silen W: Effect of imadizole and its analogs on gastric secretion in frogs and dogs. Fed Proc 23:214, 1964Google Scholar
  69. 69.
    Honeyman T, Goodman HM: Histamine activates cyclic nucleotide phosphodiesterase. Fed Proc 30:435, 1971Google Scholar
  70. 70.
    Gregory H: Some polypeptides influencing gastric acid secretion. Am J Dig Dis 15:141–148, 1970CrossRefGoogle Scholar
  71. 71.
    Makhlouf GM: Effects of gastrin and its derivatives in man. Fed Proc 27:1322–1327, 1968PubMedGoogle Scholar
  72. 72.
    Smith AN, Hogg D: Effect of gastrin II on the motility of the gastrointestinal tract. Lancet 1:403–404, 1966CrossRefPubMedGoogle Scholar
  73. 73.
    Henriksen FW, Worning H: The mutual influence of gastrin and secretin on the external pancreatic secretion in dogs. Acta Physiol Scand 76:67–72, 1969PubMedGoogle Scholar
  74. 74.
    Sanders SS, White AS, Rehm WS: Effect of adenine compounds on motility of frog gastric mucosa. Fed Proc 25:514, 1966Google Scholar
  75. 75.
    Bertaccini G, Endean R, Erspamer V, et al: The actions of cerulein on gastric secretion of the dog and the rat. Br J Pharmacol Chemother 34:311–329, 1968Google Scholar
  76. 76.
    Bertaccini G, deCaro G, Endean R, et al: The actions of caerulein on the smooth muscle of the gastrointestinal tract and the gall bladder. Br J Pharmacol Chemother 34:291–310, 1968Google Scholar
  77. 77.
    Erspamer V: Progress report: caerulein. Gut 11:79–87, 1970PubMedGoogle Scholar
  78. 78.
    Mantovani P: Activity of caerulein on peptic secretion in the rat. Pharmacol Res Comm 1:97–99, 1969Google Scholar
  79. 79.
    Senft G, Schultz G, Munske E, et al: Influence of insulin on cyclic 3',5'-AMP phosphodiesterase activity in liver, skeletal muscle, adipose tissue and kidney. Diabetologia 4:322–329, 1968CrossRefPubMedGoogle Scholar
  80. 80.
    Exton JH, Park CR: The role of cyclic AMP in the control of liver metabolism. Adv Enzyme Regul 5:391–407, 1968CrossRefGoogle Scholar
  81. 81.
    Kronborg O: The activation of gastric acid secretion by insulin hypoglycemia. Scand J Gastroent 5:481–483, 1970PubMedGoogle Scholar
  82. 82.
    Amer MS: Effects of epinephrine (Epi) and α-adrenergic agonists on adenosine 3'-5' cyclic monophosphate (cAMP) phosphodiesterase (PDE) from rabbit tissues. Fed Proc 30:220, 1971Google Scholar
  83. 83.
    Turtle JR, Kipnis DM: An adrenergic receptor mechanism for the control of cyclic 3'-5'-adenosine monophosphate synthesis in tissues. Biochem Biophys Res Comm 28:797–802, 1967CrossRefPubMedGoogle Scholar
  84. 84.
    Gagnon DJ: Intestinal smooth muscles: demonstration of catecholamine-induced contraction mediated through α-adrenergic receptors. Europ J Pharmacol 10:297–300, 1970CrossRefGoogle Scholar
  85. 85.
    Preshaw RM: Effect of vagotomy on the acid response to gastric distension. Canad J Physiol Pharmacol 48:670–674, 1970Google Scholar
  86. 86.
    Honda F, Imamura H: Inhibition of cyclic 3',5'-nucleotide phosphodiesterase by phenothiazine and reserpine derivatives Biochem Biophys Acta 161:267–269, 1968PubMedGoogle Scholar
  87. 87.
    Abdulla YH, Hamadah K: 3'5'-cyclic adenosine monophosphate in depression and mania. Lancet 1:378–381, 1970CrossRefPubMedGoogle Scholar
  88. 88.
    DiPalma JR (Ed.): Drill's Pharmacology in Medicine. Third edition. New York, McGraw-Hill Book Company, 1965Google Scholar
  89. 89.
    Hano J, Bugajski J: The inhibition of spontaneous gastric secretion in rat by some centrally active drugs. Dissert Pharm Pharmacol 21:289–308, 1969Google Scholar
  90. 90.
    Pfeiffer CJ, Roth JLA: Studies on the secretory and cytotoxic actions of caffeine on the ferret gastric mucosa. Exp Mol Pathol 13:66–78, 1970CrossRefPubMedGoogle Scholar
  91. 91.
    Jacobson ED: Comparison of prostaglandin E1 and norepinephrine on the gastric mucosal circulation. Proc Soc Exp Biol Med 133:516–519, 1970PubMedGoogle Scholar
  92. 92.
    Nayler WG: Calcium exchange in cardiac muscle: a basic mechanism of drug action. Am Heart J 73:379–394, 1967CrossRefPubMedGoogle Scholar
  93. 93.
    Nakajima S, Shoemaker RL, Hirschowitz BI, et al: Comparison of the actions of aminophyl-line and pentagastrin onNecturus gastric mucosa. Am J Physiol 219:1259–1262, 1970PubMedGoogle Scholar
  94. 94.
    Yu BP, Masoro EJ, De Martinis FD: Imidazole and sequestration of calcium ions by sacroplasmic reticulum. Nature (Lond) 216:822–824, 1967Google Scholar
  95. 95.
    Sutherland EW, Robinson GA, Butcher RW; Some aspects of the biological role of adenosine 3',5'-monophosphate (cyclic AMP). Circulation 37:279–306, 1968Google Scholar
  96. 96.
    Berkowitz BA, Tarver JH, Spector S: Norepinephrine release by theophylline and caffeine. Fed Proc 28:415, 1969Google Scholar
  97. 97.
    Westfall DP, Fleming WW: Sensitivity changes in the dog heart to norepinephrine calcium and aminophylline resulting from pretreatment with reserpine. J Pharmacol Exp Ther 159:98–106, 1968PubMedGoogle Scholar
  98. 98.
    McNeil JH, Massar M, Brody TM: The effect of theophylline on amine-induced cardiac phosphorylase activation and contractility. J Pharmacol Exp Ther 165:234–241, 1969PubMedGoogle Scholar
  99. 99.
    Weber A: The mechanism of the action of caffeine on sarcoplasmic reticulum. J Gen Physiol 52:760–772, 1968CrossRefPubMedGoogle Scholar
  100. 100.
    Konturek SJ, Gaboys B, Dubiel J: Effect of exogenous and endogenous secretion on gastric and pancreatic secretion in cats. Am J Physiol 217:1110–1113, 1969PubMedGoogle Scholar
  101. 101.
    McGuigan JE: On the “coming-of-age” of neuro-humoral gastroenterology. Am J Med Sci 259:73–78, 1970PubMedGoogle Scholar
  102. 102.
    Gregory RA: Recent advances in the physiology of gastrin. Proc Roy Soc B 170:81–88, 1968Google Scholar
  103. 103.
    Uvnas B: Gastrin and vagus. Gastroenterology 56:812–815, 1969PubMedGoogle Scholar

Copyright information

© Hoeber Medical Division • Harper & Row, Publishers, Incorporated 1972

Authors and Affiliations

  • M. Samir Amer
    • 1
  1. 1.Mead Johnson Research CenterEvansville

Personalised recommendations