The American Journal of Digestive Diseases

, Volume 15, Issue 4, pp 321–326 | Cite as

Clinical course of ulcerative proctosigmoiditis

  • F. Warren Nugent
  • Malcolm C. Veidenheimer
  • Sarwar Zuberi
  • Mamigon M. Garabedian
  • Navin K. Parikh


Ulcerative colitis confined to the rectum or rectum and sigmoid was studied in 234 patients. During a prolonged period of follow-up, these patients had an extremely benign clinical course when compared with that experienced with the diffuse disease. A minimum of morbidity and not a single death occurred. Only 10 patients required operation on the colon for control of disease. Extracolonic manifestations were virtually absent. No malignant degeneration occurred. Although we believe that this disease is part of the spectrum of ulcerative colitis, its anatomic confinement to the distal colon allows prediction of a much more benign clinical course.


Public Health Ulcerative Colitis Distal Colon Diffuse Disease Malignant Degeneration 
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  1. 1.
    Thaysen, T. E. H. Simple hemorrhagic proctitis and proctosigmoiditis.Acta Med Scand 84:1, 1934.Google Scholar
  2. 2.
    Brooke, B. N. What is ulcerative colitis?Lancet 1:1220, 1953.Google Scholar
  3. 3.
    Farmer, R. G., andBrown, C. H. Ulcerative proctitis: course and prognosis.Gastroenterology 51:219. 1966.Google Scholar
  4. 4.
    Hill, J. R. Ulceration of the rectum and terminal portion of the colon: Significance in absence of malignant disease and chronic ulcerative colitis.Arch Surg 75:1029, 1957.Google Scholar
  5. 5.
    Truelove, S. C. Suppository treatment of haemorrhagic proctitis.Brit Med J 1:955, 1959.Google Scholar
  6. 6.
    Sparberg, M., Fennessy, J., andKirsner, J. B. Ulcerative proctitis and mild ulcerative colitis: A study of 220 patients.Medicine 45:391, 1966.Google Scholar
  7. 7.
    Lennard-Jones, J. E., Cooper, G. W., Newell, A. C., Wilson, C. W., andJones, F. A. Observations on idiopathic proctitis.Gut 3:201, 1962.Google Scholar
  8. 8.
    Diaz, R. J., Farmer, R. G., andBrown, C. H. Carcinoma of the colon and ulcerative colitis.Amer J Dig Dis 10:643, 1965.Google Scholar
  9. 9.
    Weckesser, E. C., andChinn, A. B. Carcinoma of the colon complicating chronic ulcerative colitis.JAMA 152:905, 1953.Google Scholar
  10. 10.
    Nugent, F. W., andRudolph, N. E. Extracolonic manifestations of chronic ulcerative colitis.Med Clin N Amer 50:529, 1966.Google Scholar
  11. 11.
    Kelley, M. L., Jr. Chronic ulcerative colitis at a medical center in western New York State: Complications and course.New York J Med 63:2061, 1963.Google Scholar
  12. 12.
    Bockus, H. L., Roth, J. L., Buchman, E., Kalser, M., Staub, W. R., Finkelstein, A., and Valdes-Dapena, A. Life history of non-specific ulcerative colitis: Relation of prognosis to anatomical and clinical varieties.Gastroenterologia 86:549, 1956.Google Scholar
  13. 13.
    MacDougall, I. P. The cancer risk in ulcerative colitis.Lancet 2:655, 1964.Google Scholar
  14. 14.
    Edwards, F. C., andTruelove, S. C. The course and prognosis of ulcerative colitis.Gut 4:299, 1963.Google Scholar
  15. 15.
    Lyons, A. S., andGarlock, J. H. The relationship of chronic ulcerative colitis to carcinoma.Gastroenterology 18:170, 1951.Google Scholar
  16. 16.
    Veidenheimer, M. C., andNugent, F. W. Treatment of chronic ulcerative colitis.Surg Clin N Amer 48:559, 1968.Google Scholar

Copyright information

© Hoeber Medical Division • Harper & Row, Publishers, Incorporated 1970

Authors and Affiliations

  • F. Warren Nugent
    • 1
  • Malcolm C. Veidenheimer
    • 1
  • Sarwar Zuberi
    • 1
  • Mamigon M. Garabedian
    • 1
  • Navin K. Parikh
    • 1
  1. 1.From the Departments of Gastroenterology and SurgeryLahey Clinic FoundationBoston

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