Abstract
Two patients with pancreatitis and hyperamylasemia had an acquired double albumin on serum electrophoresis, with the anomalous albumin migrating more rapidly than the normal. The quantity of the rapidly migrating fraction appeared to be directly related to the serum amylase level. No immunologic differences were detectable between the two albumins. Several studies suggested that the elevated serum amylase level was not caused by macroamylasemia. Possible mechanisms for the production of double albumin include: amylase to albumin binding, an enzymatic change of albumin by amylase, or the presence in serum of other substances that alter the electric charge of albumin.
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Scheurlen PG: Uber serumeiweiss veranderungen beim diabetes mellitus. Klin Wochenschr 33:198–205, 1955
Earle DP, Hutt MP, Schmid K et al: Observations on double albumin: A genetically transmitted serum protein anomaly. J Clin Invest 38:1412–1420, 1959
Franglen G, Martin NH, Hargreaves T, et al: Bisalbuminemia: A hereditary albumin abnormality. Lancet 1:307–308, 1960
Wieme RJ: On the presence of two albumins in certain normal human sera and its genetic determination. Clin Chim Acta 5:443–445, 1966
Gabl VF, Huber EG: Passagere, nicht hereditare doppelalbuminamie. Ann Paediatr (Paris) 202:81–91, 1964
Arvan DA, Blumberg BS, Melartin L: Transient “Bisalbuminemia” induced by drugs. Clin Chim Acta 22:211–218, 1968
Stoodley BJ, Rowe DJ: Pancreatitis with hyperamylasaemia and bisalbuminaemia. Br Med J 2:30–31, 1970
Peralta O, Reinhold JG: Rapid estimation of amylase activity of serum by turbidimetry. Clin Chem 1:157–164, 1955
Fahey JL, McLaughlin C: Preparation of antisera specific for 6.6S gammaglobulins, Beta2A globulins, gamma1 macroglobulins, and for type I and II, common gammaglobulin determinants. J Immunol 91:484–497, 1963
Bonazzi L: On a rare genetic variation of plasma albumin: Bisalbuminemia. Clin Chim Acta 20:362–363, 1968
Laurell C-B, Nilenn J-E: A new type of inherited serum albumin anomaly. J Clin Invest 45:1935–1945, 1966
Efremov G, Braend M: Serum albumin: Polymorphism in Man. Science 146:1679–1680, 1964
Cooke KB, Cleghorn TE, Lockey E: Two new families with bisalbuminemia: An examination of possible links with other genetically controlled variants. Proc Biochem Soc 81:39–40, 1961
Blumberg BS, Martin JR, Melartin L: Alloalbuminemia: Albumin Naskapi in Indians of the Ungava. JAMA 203:180–185, 1968
Bell HE, Nicholson SF, Thompson ZR: Bisalbuminemia of the fast type with a homozygote. Clin Chim Acta 15:247–252, 1967
Robbins JL, Hill GA, Marcus S, et al: Paralbuminemia: Paper and cellulose acetate electrophoresis and preliminary immunoelectrophoretic analysis. J Lab Clin Med 62:753–761, 1963
Gitlin D, Schmid K, Earle DP, et al: Observations on double albumin. II: A peptide difference between two genetically determined human serum albumins. J Clin Invest 40:821–827, 1961
Levitt MD, Rapoport M, Cooperband SR: The renal clearance of amylase in renal insufficiency, acute pancreatitis and macroamylasemia. Ann Intern Med 71:919–925, 1969
Levitt MD, Copperband SR: Hyperamylasemia binding of serum amylase by 11S IgA gamma globulin. N Engl J Med 278:474–479, 1968
McGeachin RL, Lewis JP: Electrophoretic behavior of serum amylase. J Biol Chem 234:795–798, 1959
Joseph RR, Olivero E, Ressler N: Electrophoretic study of human isoamylases. Gastroenterology 51:377–378, 1966
Berk JE, Searcy RL, Hayashi S, et al: Distribution of serum amylase in man and animals. Electrophoretic and chromatographic studies. JAMA 192:389–392, 1965
Putnam FW: The Plasma Proteins, Vol. 1. New York, Academic Press, 1960, p 314
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Shashaty, G.G., Atamer, M.A. & Shields, M.E. Acquired bisalbuminemia with hyperamylasemia. Digest Dis Sci 17, 59–67 (1972). https://doi.org/10.1007/BF02239262
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DOI: https://doi.org/10.1007/BF02239262