The American Journal of Digestive Diseases

, Volume 17, Issue 1, pp 59–67 | Cite as

Acquired bisalbuminemia with hyperamylasemia

  • George G. Shashaty
  • M. A. Atamer
  • Miss Eleanor Shields
Original Articles

Abstract

Two patients with pancreatitis and hyperamylasemia had an acquired double albumin on serum electrophoresis, with the anomalous albumin migrating more rapidly than the normal. The quantity of the rapidly migrating fraction appeared to be directly related to the serum amylase level. No immunologic differences were detectable between the two albumins. Several studies suggested that the elevated serum amylase level was not caused by macroamylasemia. Possible mechanisms for the production of double albumin include: amylase to albumin binding, an enzymatic change of albumin by amylase, or the presence in serum of other substances that alter the electric charge of albumin.

Keywords

Public Health Albumin Pancreatitis Electrophoresis Amylase 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Scheurlen PG: Uber serumeiweiss veranderungen beim diabetes mellitus. Klin Wochenschr 33:198–205, 1955Google Scholar
  2. 2.
    Earle DP, Hutt MP, Schmid K et al: Observations on double albumin: A genetically transmitted serum protein anomaly. J Clin Invest 38:1412–1420, 1959Google Scholar
  3. 3.
    Franglen G, Martin NH, Hargreaves T, et al: Bisalbuminemia: A hereditary albumin abnormality. Lancet 1:307–308, 1960Google Scholar
  4. 4.
    Wieme RJ: On the presence of two albumins in certain normal human sera and its genetic determination. Clin Chim Acta 5:443–445, 1966Google Scholar
  5. 5.
    Gabl VF, Huber EG: Passagere, nicht hereditare doppelalbuminamie. Ann Paediatr (Paris) 202:81–91, 1964Google Scholar
  6. 6.
    Arvan DA, Blumberg BS, Melartin L: Transient “Bisalbuminemia” induced by drugs. Clin Chim Acta 22:211–218, 1968Google Scholar
  7. 7.
    Stoodley BJ, Rowe DJ: Pancreatitis with hyperamylasaemia and bisalbuminaemia. Br Med J 2:30–31, 1970Google Scholar
  8. 8.
    Peralta O, Reinhold JG: Rapid estimation of amylase activity of serum by turbidimetry. Clin Chem 1:157–164, 1955Google Scholar
  9. 9.
    Fahey JL, McLaughlin C: Preparation of antisera specific for 6.6S gammaglobulins, Beta2A globulins, gamma1 macroglobulins, and for type I and II, common gammaglobulin determinants. J Immunol 91:484–497, 1963Google Scholar
  10. 10.
    Bonazzi L: On a rare genetic variation of plasma albumin: Bisalbuminemia. Clin Chim Acta 20:362–363, 1968Google Scholar
  11. 11.
    Laurell C-B, Nilenn J-E: A new type of inherited serum albumin anomaly. J Clin Invest 45:1935–1945, 1966Google Scholar
  12. 12.
    Efremov G, Braend M: Serum albumin: Polymorphism in Man. Science 146:1679–1680, 1964Google Scholar
  13. 13.
    Cooke KB, Cleghorn TE, Lockey E: Two new families with bisalbuminemia: An examination of possible links with other genetically controlled variants. Proc Biochem Soc 81:39–40, 1961Google Scholar
  14. 14.
    Blumberg BS, Martin JR, Melartin L: Alloalbuminemia: Albumin Naskapi in Indians of the Ungava. JAMA 203:180–185, 1968Google Scholar
  15. 15.
    Bell HE, Nicholson SF, Thompson ZR: Bisalbuminemia of the fast type with a homozygote. Clin Chim Acta 15:247–252, 1967Google Scholar
  16. 16.
    Robbins JL, Hill GA, Marcus S, et al: Paralbuminemia: Paper and cellulose acetate electrophoresis and preliminary immunoelectrophoretic analysis. J Lab Clin Med 62:753–761, 1963Google Scholar
  17. 17.
    Gitlin D, Schmid K, Earle DP, et al: Observations on double albumin. II: A peptide difference between two genetically determined human serum albumins. J Clin Invest 40:821–827, 1961Google Scholar
  18. 18.
    Levitt MD, Rapoport M, Cooperband SR: The renal clearance of amylase in renal insufficiency, acute pancreatitis and macroamylasemia. Ann Intern Med 71:919–925, 1969Google Scholar
  19. 19.
    Levitt MD, Copperband SR: Hyperamylasemia binding of serum amylase by 11S IgA gamma globulin. N Engl J Med 278:474–479, 1968Google Scholar
  20. 20.
    McGeachin RL, Lewis JP: Electrophoretic behavior of serum amylase. J Biol Chem 234:795–798, 1959Google Scholar
  21. 21.
    Joseph RR, Olivero E, Ressler N: Electrophoretic study of human isoamylases. Gastroenterology 51:377–378, 1966Google Scholar
  22. 22.
    Berk JE, Searcy RL, Hayashi S, et al: Distribution of serum amylase in man and animals. Electrophoretic and chromatographic studies. JAMA 192:389–392, 1965Google Scholar
  23. 23.
    Putnam FW: The Plasma Proteins, Vol. 1. New York, Academic Press, 1960, p 314Google Scholar

Copyright information

© Hoeber Medical Division • Harper & Row, Publishers, Incorporated 1972

Authors and Affiliations

  • George G. Shashaty
    • 1
  • M. A. Atamer
    • 1
  • Miss Eleanor Shields
    • 1
  1. 1.From the Section of Hematology and Immunology, Division of MedicineGrasslands HospitalValhalla

Personalised recommendations