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Acquired bisalbuminemia with hyperamylasemia

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Abstract

Two patients with pancreatitis and hyperamylasemia had an acquired double albumin on serum electrophoresis, with the anomalous albumin migrating more rapidly than the normal. The quantity of the rapidly migrating fraction appeared to be directly related to the serum amylase level. No immunologic differences were detectable between the two albumins. Several studies suggested that the elevated serum amylase level was not caused by macroamylasemia. Possible mechanisms for the production of double albumin include: amylase to albumin binding, an enzymatic change of albumin by amylase, or the presence in serum of other substances that alter the electric charge of albumin.

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Shashaty, G.G., Atamer, M.A. & Shields, M.E. Acquired bisalbuminemia with hyperamylasemia. Digest Dis Sci 17, 59–67 (1972). https://doi.org/10.1007/BF02239262

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