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Evaluation of the renal injury from gold salts and nonsteroidal anti-inflammatory drugs in patients with rheumatoid arthritis

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Summary

The urinary excretion of proteins, N-acetil-3-glucosaminidase and leucine aminopeptidase, was measured in 50 patients with rheumatoid arthritis (RA), of whom 20 subjects were on nonsteroidal anti-inflammatory drugs (NSAIDs) and 30 on gold salts. No pathological changes of the above-mentioned urinary parameters have been observed in the group of RA patients, in comparison with control subjects and patients suffering from osteoarthritis treated with NSAIDs.

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References

  1. Blackshear, J.L., Napier, J.S., Davidman, M., Stillman, T. Renal complications of nonsteroidal anti-inflammatory drugs: Identification and monitoring of those at risk. Semin Arthritis Rheum 1985, 14, 163–175.

    Article  PubMed  Google Scholar 

  2. Clive, D.M., Stoff, J.S. Renal syndromes associated with nonsteroidal anti-inflammatory drugs. New Engl J Med 1984, 310, 563–572.

    PubMed  Google Scholar 

  3. Dunn, M.J. Nonsteroidal anti-inflammatory drugs and renal function. Ann Rev Med 1984, 35, 411–428.

    Article  PubMed  Google Scholar 

  4. Gerber, R.C., Paulus, H.E. Gold Therapy. Clin Rheum Dis 1975, 1, 307–318.

    Google Scholar 

  5. Hart, F.D., Lewis-Faning, E. Gold therapy in rheumatoid arthritis. Final report of a multicentre controlled trial. Ann Rheum Dis 1961, 20, 315–334.

    Google Scholar 

  6. Marcolongo, R., Di Paolo, N. Ricerche sulla funzionalità renale in pazienti affetti da artrite reumatoide. La Sett Medica 1970, 58, 809.

    Google Scholar 

  7. Sorensen, A.W.S. The kidney function in relation to drug consumption in patients with rheumatoid arthritis. Acta Rheum Scand 1963, 9, 122–140.

    Google Scholar 

  8. Silverberg, D.S., Kidd, E.G. et al. Gold nephropathy. Arthritis Rheum. 1970, 13, 812–825.

    PubMed  Google Scholar 

  9. Skrifvars, B.V., Tornroth, T.S. et al. Gold-induced immune complex nephritis in seronegative rheumatoid arthritis. Ann Rheum Dis 1977, 36, 549–556.

    PubMed  Google Scholar 

  10. Appel, G.B., Kunis, G.L. Acute tubulo-interstitial nephritis, in tubulo-interstitial nephropathies. Editors: Cotran, R.S., Brenner, B.M., Stein, J.H. New York, Churchill Livingstone 1983, 151–185.

    Google Scholar 

  11. Linton, A.L., Clark, W.F., Driedger, A.A. et al. Acute interstitial nephritis due to drugs. Ann Intern Med 1980, 93, 735–741.

    PubMed  Google Scholar 

  12. Marcolongo, R. I farmaci antiflogistici non steroidei. Farmaci 1977, 1, 25–40.

    Google Scholar 

  13. Strunk, S.W., Ziff, M. Ultrastructural studies of the passage of gold thiomalate across the renal glomerular capillary wall. Arthritis Rheum. 1970, 13, 39–52.

    PubMed  Google Scholar 

  14. Crisp, A.J., Coughlan, R.J. et al. Failure of sodium aurothiomalate and triethylphosphine gold to cause renal tubular injury in rheumatoid arthritis: implication for aetiology of gold-related nephropathy. Clin Rheumatol 1983, 2, 273–276.

    Article  PubMed  Google Scholar 

  15. Maddox, D.A., Bennet, C.M., Dee, W.M. et al. Determinant of glomerular filtration in experimental glomerulonephritis in rat. J Clin Invest 1975, 55, 305–318.

    PubMed  Google Scholar 

  16. Gordon, D.A., Koehler, B.E., Russel, M.L. et al. The clinical significance of immune complexes in rheumatoid disease. Ann NY Acad Sci 1975, 256, 338–346.

    PubMed  Google Scholar 

  17. Waltz, D.T., Mischer, A., Finkelstein, A.E. et al. SK&F D-39162: A unique antiarthritic agent for the treatment of rheumatoid arthritis. Drugs Exp Clin Res 1977, 2, 47–61.

    Google Scholar 

  18. Gottlieb, N.L. Comparative pharmakinetics of parenteral and oral gold compounds. J Rheumatol 1982, 9, (Suppl. 8), 99–109.

    Google Scholar 

  19. Blackshear, J.L., Davidman, M., Stilmann, M.T. Identification of risk for renal insufficiency from nonsteroidal anti-inflammatory drugs. Arch Intern Med 1983, 143, 1130–1134.

    Article  PubMed  Google Scholar 

  20. Henrich, W.L. Nephrotoxicity of nonsteroidal anti-inflammatory agents. Am J Kidney Dis 1983, 2, 478–483.

    PubMed  Google Scholar 

  21. Unsworth, J., Sturman, J., Lunec, J., Blake, D.R. Renal impairment associated with nonsteroidal anti-inflammatory drugs. Ann Rheum Dis 1987, 46, 233–236.

    PubMed  Google Scholar 

  22. Reeve, B.W., Foley, R.J., et al. Renal dysfunction from nonsteroidal anti-inflammatory drugs. Arch Intern Med 1984, 144, 1943–1944.

    Article  PubMed  Google Scholar 

  23. Patrono, C. Farmaci antiflogistici non steroidei, sistema prostaglandinico e funzione renale. Il Progresso Medico 1984, 11, 689–695.

    Google Scholar 

  24. Salomon, M.I., Gallo, G., Poon, T.P., Golblat, M.V., Tchertkoff, V.: The kidney in rheumatoid arthritis: a study based on renal biopsies. Nephron 1974, 12, 297–310.

    PubMed  Google Scholar 

  25. Galler, M., Folkert, V.W., Schlondorff, D. Reversible acute renal insufficiency and hyperkalemia following indomethacin therapy. JAMA 1981, 246, 154–155.

    Article  PubMed  Google Scholar 

  26. Kimberly, R.P., Bowden, R.E., Keiser, H.R., Plotz, P.H. Reduction of renal function by newer nonsteroidal anti-inflammatory drugs. Am J Med 1978, 64, 804–807.

    Article  PubMed  Google Scholar 

  27. Brezin, J.H., Katz, S.M., Schwartz, A.B. et al. Reversible renal failure and nephrotic syndrome associated with nonsteroidal anti-inflammatory drugs. New Engl J Med 1979, 301, 1271–1273.

    PubMed  Google Scholar 

  28. Murray, T.G. Drug-induced chronic tubulointerstitial renal disease. Contemp Issues Nephrol 1983, 10, 187–209.

    Google Scholar 

  29. Feldman, D., Loose, D.S., Tan, S.Y. Nonsteroidal anti-inflammatory drugs cause sodium and water retention in the rat. Am J Physiol 1978, 234, 490–496.

    Google Scholar 

  30. Dunn, M.J., Zambraski, E.J. Renal effects of drugs that inhibit prostaglandin synthesis. Kidney Int 1980, 18, 609–622.

    PubMed  Google Scholar 

  31. Pugliese, F., Ciabattoni, G. The role of prostaglandins in the control of renal function: renal effects of nonsteroidal anti-inflammatory drugs. Clin Exp Rheumatol 1984, 2, 345–352.

    PubMed  Google Scholar 

  32. Mac Cluckey, R.T., Klassen, J. Immunologically mediated glomerular tubular and interstitial renal disease. New Engl J Med 1973, 288, 564–570.

    PubMed  Google Scholar 

  33. Pasternak, D., Linder, E. Renal tubular acidosis in immunopathologic study of four patients. Clin Exp Immunol 1970, 7, 115–123.

    PubMed  Google Scholar 

  34. Bradford, M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye-binding. Ann Biochem 1976, 72, 248–254.

    Article  Google Scholar 

  35. Tucker, S.M., Boyd, P.J.R., Thompson, A.E., Price, R.G. Automated assay of NAG in normal and pathological human urine. Clin Chem Acta 1975, 62, 333–339.

    Article  Google Scholar 

  36. Clemenzia, G., Laterza, G., Russo, G., Santini, P., Scibinetti, F. Gentile, V., Liberti, M., De Vito, R. I valori normali dell'attività urinaria di 4 enzimi. Minerva Med 1984, 75, 2591–2596.

    PubMed  Google Scholar 

  37. Laterza, G., Clemenzia, G., Russo, G., Santini, P., Scibinetti, F., Gentile, V., De Bernardis, S., Mainieri, F. Il comportamento di 4 enzimurie nei soggetti sani secondo l'età, il sesso, il peso corporeo e la statura. Minerva Med 1984, 75, 2829–2831.

    PubMed  Google Scholar 

  38. Merle, J.L., Reidenberg, M.M. Camacho, M.T., Jones, B.R., Drayer, D.E. Renal injury in patients with rheumatoid arthritis treated with gold. Clin Pharmacol Ther 1980, 28, 216–222.

    PubMed  Google Scholar 

  39. Fox, D.A., Jick, H. Nonsteroidal anti-inflammatory drugs and renal disease. JAMA 1984, 251, 1299–1300.

    Article  PubMed  Google Scholar 

  40. Marcolongo, R., Giordano, N., Lucchese, M. Il rene nell'artrite reumatoide. Atti del Simposio: Rene e Malattie reumatiche, Edizioni Minerva Medica, Milano 1979, 629–646.

    Google Scholar 

  41. Boers, M., Croonen, A.M., Dijkmons, D.E.C., Breedveld, F.C., Eulderink, F., Cats, A., Weening, J.J. Renal findings in rheumatoid arthritis: clinical aspects of 132 necropsies. Ann Rheum Dis 1987, 46, 658–663.

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Institute of Rheumatology of the University of Siena, Siena, Italy

    N. Giordano, E. Frati, A. Fioravanti, A. Taddeo, G. Morozzi &  R. Marcolongo

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  1. N. Giordano
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  2. E. Frati
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  3. A. Fioravanti
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  4. A. Taddeo
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  5. G. Morozzi
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  6. R. Marcolongo
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Giordano, N., Frati, E., Fioravanti, A. et al. Evaluation of the renal injury from gold salts and nonsteroidal anti-inflammatory drugs in patients with rheumatoid arthritis. Clin Rheumatol 7, 342–346 (1988). https://doi.org/10.1007/BF02239190

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  • DOI: https://doi.org/10.1007/BF02239190

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