Journal of Neuro-Visceral Relations

, Volume 31, Issue 2, pp 171–188 | Cite as

Effect of stimulation and coagulation of the midbrain reticular formation on the bronchial musculature; a modification of histamine susceptibility

  • A. Przybylski


The influence of the midbrain reticular formation on bronchial muscle tonus in the guinea pig was examined. In the midbrain reticular formation functionally interrelated regions were distinguished that play a role in the control of bronchial smooth muscle tonus. The dorso-caudal regions of the midbrain reticular formation activate the constriction of the bronchial tubes, whereas the ventro-rostral regions exert an antagonistic influence. The dorso-caudal regions act on the effector mainly by phasic regulation through the parasympathetic nervous system. The facilitation of the dilatatory reaction is connected with the prepotency of the sympathetic nervous system and an activation of the hypophysio-adrenal system.


Smooth Muscle Histamine Sympathetic Nervous System Muscle Tonus Phasic Regulation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Bei Meerschweinchen wurde die Einwirkung der Formatio reticularis des Hirnstammes auf den Tonus der Bronchialmuskulatur untersucht. In der Formatio reticularis wurden die funktionell zusammenhängenden Strukturen, welche den Tonus der Bronchialmuskulatur regulieren, lokalisiert. Die dorso-caudalen Gebiete der Formatio reticularis aktivieren die Verengerung der Atmungswege, die ventrorostralen Gebiete wirken antagonistisch auf die glatte Bronchialmuskulatur. Die dorso-caudalen Gebiete wirken über das parasympathische Nervensystem. Die Aktivierung der Entspannung hängt mit dem überwiegenden Einfluß des sympathischen Nervensystems zusammen und ist an die Aktivierung des hypophysäradrenalen Systems gebunden.


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  1. Bass, A. D., andJ. A. Setliff: The in vitro actions of steroids on smooth muscle. Pharmacol. Exp. Ther.130, 469–473 (1960).Google Scholar
  2. Beyer, C., S. Tindal, andC. H. Sawyer: Electrophysiological study of projections from mesencephalic central gray matter to forebrain in the rabbit. Exp. Neurol.6, 435–450 (1962).Google Scholar
  3. Bonvalet, M., P. Dell, etD. Hiebel: Tonus sympathique et activité électrique corticale. Electroenc. clin. Neurophysiol.6, 119–145 (1954).Google Scholar
  4. Casentini, S., A. Poli, S. de Hunkovic, andL. Martini: Studies on the control of corticotropin release. Endocrinologie64, 483–493 (1959).Google Scholar
  5. Collier, H. O., andP. G. Schorley: Analgesic antipyretic drugs as antagonists of bradykinin. Brit. J. Pharmacol.15, 601–610 (1960).Google Scholar
  6. Csalay, L., G. Horvath, P. Kertay, undK. Ivanyi: Wirkung von ACTH und Cortison auf die Histaminempfindlichkeit. Acta Physiol. Hung.5, 3–4 (1954).Google Scholar
  7. Dautrebande, L.: Microaerosols. New York: Academic Press, 1962.Google Scholar
  8. Endröczi, E., andK. Lissák: Effect of hypothalamic and brain stem structures stimulation on pituitary-adrenocortical function. Acta Physiol. Hung.24, 67–77 (1963).Google Scholar
  9. Endröczi, E., K. Lissák, andB. Bohus: The inhibitory influence of archicortical structures on pituitary-adrenal function. Acta Physiol. Hung.16, 17–22 (1959).Google Scholar
  10. —,G. Schreiberg, andK. Lissák: The role of central nervous activating and inhibitory structures in the control of pituitary-adrenocortical function. Acta Physiol. Hung.24, 211–221 (1963).Google Scholar
  11. Feldman, S.: Effect of reticular formation lesions on afferent projection to the hypothalamus. Electroenc. clin. Neurophysiol.15, 672–682 (1963).Google Scholar
  12. François-Franck, C. A., 1887 (cited byJ. G. Widdicombe): Regulation of tracheobronchial smooth muscle. Physiol. Rev.43, 1–37 (1963).Google Scholar
  13. —: Influence des excitations du cerveau sur les principales fonctions organiques. C. R. Soc. Biol., Paris,40, 27–43 (1888).Google Scholar
  14. Freedman, D. X., andG. Fenichel: Effect of midbrain lesion on experimental allergy. Am. Arch. Neurol.79, 164–169 (1958).Google Scholar
  15. Fuche, J.: Histamine as a stimulant to the anterior pituitary gland as judged by the lymphopenic response in normal and hypophysectomized rabbits. Acta physiol. scand.39, 327–347 (1957).Google Scholar
  16. Giuliani, G., L. Martini, andA. Pecile: Midbrain sections and release of ACTH following stress. Acta neuroveget., Wien,23, 21–34 (1961).Google Scholar
  17. Groot, J. de, andG. W. Harris: Hypothalamic control of the anterior pituitary gland and blood lymphocytes. J. Physiol., Paris,111, 335–346 (1950).Google Scholar
  18. Gross, F.: Die Beeinflussung des Histaminschockes durch Desoxycorticosteron am nebennierenlosen Meerschweinchen. Helvet. Physiol. Pharmacol. Acta6, 114–121 (1948).Google Scholar
  19. Guillemin, R.: A re-evaluation of acetylcholine, adrenaline, noradrenaline and histamine as possible mediators of the pituitary-adrenocorticotrophic activation by stress. Endocrinologie56, 248–255 (1955).Google Scholar
  20. Halpern, B. N., etS. A. Benos: Action de l'histamine sur l'éosinophilie sanguine chez l'animal et l'homme. C. R. Soc. Biol., Paris,145, 31–37 (1951).Google Scholar
  21. Hess, W. R.: Hypothalamus and Thalamus. Stuttgart: G. Thieme, 1956.Google Scholar
  22. Hunsperger, R. W.: Afterreaktionen auf elektrische Reizung im Hirnstamm der Katze. Helvet. physiol. pharmacol. Acta14, 70–92 (1956).Google Scholar
  23. Ingram, W. R., J. Field, H. W. Magoun, andV. E. Hall: Handbook of Physiology. Washington: Amer. Physiol. Soc., 1960.Google Scholar
  24. Kahn, R. H.: Zur Physiologie der Trachea. Arch. Anat. Physiol.5/6, 398–426 (1907).Google Scholar
  25. Karczewski, W.: The electrical activity of the vagus nerve in anaphylactic shock. Acta allergol.17, 334–342 (1962).Google Scholar
  26. Kovach, A.: A kiserleti orvostudomány vizsgáló módszerei, III. Budapest: Akadémiai Kiadó, 1957.Google Scholar
  27. Martini, L., A. Pecile, S. Saito, andF. Tanci: The effect of midbrain transsection on ACTH release. Endocrinologie66, 501–507 (1960).Google Scholar
  28. Maslinski, Cz., andW. Karczewki: Zapobieganie tzw. wstrzasowi histaminowemu przez draznienie mózgu pradem elektrycznym. Acta physiol. Pol.4, 373–376 (1955).Google Scholar
  29. —: The time of survival as a criterion in studies on histamine shock. Bull. Aced. Pol. Sc.10, 473–477 (1960).Google Scholar
  30. —, andJ. M. Wisniewska: Studies on adaptation to bronchoconstrictors. I. Conditions required to produce histamine adaptation. Arch. int. Pharmacodyn155, 1, 196–204 (1965).Google Scholar
  31. McCann, S. M., andP. Haberland: Further studies on the regulation of pituitary ACTH in rats with hypothalamic lesions. Endocrinologie66, 217–221 (1960).Google Scholar
  32. Moll, J.: Localization of brain stem lesions inhibiting compensatory adrenal hypertrophy following unilateral adrenalectomy. Zschr. Zellforsch.49, 515–524 (1959).Google Scholar
  33. Morin, F.: An experimental study of hypothalamic connections in the guinea pig. J. Comp. Neurol., Philadelphia,92, 193–213 (1950).Google Scholar
  34. Nauta, W. J.: Hippocampal projections and related neural pathways to the midbrain in the cat. Brain81, 319–340 (1958).Google Scholar
  35. Nauta, W. J. andH. G. Kuypers: Reticular formation of the brain. R. T. Castello, ed Boston, 1958.Google Scholar
  36. Newman, A., E. S. Redgate, andG. Farrel: The effect of diencephalic-mesencephalic lesions on aldosterone and hydrocortisone secretion. Endocrinologie63, 723–736 (1958).Google Scholar
  37. Przybylski, A.: Effect of the removal of cortex cerebri and the quadrigeminal bodies region on histamine susceptibility of guinea pigs. Acta physiol. Pol.13, 535–541 (1962).Google Scholar
  38. —: Metoda perfuzji izolowanego pluca. Modyfikacja metody Thorntona. Acta physiol. Pol.4, 709–710 (1966).Google Scholar
  39. —: Metoda rejestracji skurczu miesniówki oskrzeli in vitro. Modyfikacja metody Konzetta-Rösslera. Acta physiol. Pol.19, 1, 141–148 (1968).Google Scholar
  40. Rocheford, G. J., J. Rosenberger, andM. Saffran: Depletion of pituitary corticotrophin by various stress and by neurophysiological preparations. J. Physiol., London,146, 105–116 (1959).Google Scholar
  41. Sadowski, B., andB. Kruk: Odczyn limfopeniczny u królików jako wyraz pobudpzenia ukladu przysadkowo-nadnerczowego w stanach czynnosciowych wywolanych draznieniem mózgu. Acta physiol. Pol.15, 477–493 (1964).Google Scholar
  42. Sharpless, S. H., andA. B. Rothballer: Humoral factors released from intracranial sources during stimulation of reticular formation. Amer. J. Physiol.200, 905–915 (1961).Google Scholar
  43. Skultety, F. M.: The behavioral effects of destructive lesions of the periaqueductal gray matter in adult cats. J. Comp. Neurol.110, 337–362 (1962).Google Scholar
  44. Slusher, M. A.: Dissociation of adrenal ascorbic acid and corticosterone responses to stress in rats with hypothalamic lesions. Endocrinologie63, 412–419 (1958).Google Scholar
  45. —: Effect of brain stem lesions on stress induced corticosteroid release in female rats. Endocrinologie67, 347–352 (1960).Google Scholar
  46. —, andJ. E. Hyde: Inhibition of adrenalcorticosteroid release by brain stem stimulation in cats. Endocrinologie68, 773–782 (1961).Google Scholar
  47. Soulairac A., etA. Gottesman: Variations de l'excitabilité nerveuse centrale chez le rat sous l'influence de diverses hormones stéroïdes. J. Physiol., Paris,55, 340–341 (1963).Google Scholar
  48. Szekely, J., andA. Szentivanyi: Anaphylaxis and the nervous system. Part IV. Ann. Allergy,16, 389–392 (1958).Google Scholar
  49. Szentivanyi, A., andG. Fillip: Anaphylaxis and the nervous system. Ann. Allergy16, 143–151 (1958).Google Scholar
  50. —, andJ. Szekely: Effect of injury to and electrical stimulation of hypothalamic areas on anaphylactic and histamine shock of the guinea pig. Ann. Allergy14, 259–260 (1956).Google Scholar
  51. Talford, J. M., andG. B. West: The effect of corticosteroids and related compounds on the histamine and 5-hydroxytryptamine content of rat tissues. Brit. J. Pharmacol.15, 532–539 (1960).Google Scholar
  52. Taylor, A. N., andG. Farrel: Effects of brain stem lesions on aldosterone and cortisol secretion. Endocrinologie70, 556–566 (1962).Google Scholar
  53. Thompson, W. C., andL. M. N. Bach: Some functional connections between hypothalamus and medulla. J. Neurophysiol., Springfield,13, 455–464 (1950).Google Scholar
  54. Thorn, G. W., M. Clinton, B. M. Davis, andR. A. Lewis: Effect of adrenal cortical hormone therapy on altitude tolerance. Endocrinologie36, 381–390 (1945).Google Scholar
  55. Ward, A.: Decerebrate rigidity. J. Neurophysiol., Springfield,10, 89–103 (1947).Google Scholar
  56. Wells, H., F. N. Briggs, andP. Munson: The inhibitory effect of reserpine on ACTH secretion in response to stressful stimuli. Endocrinologie59, 571–579 (1956).Google Scholar
  57. Wied, D. de, andJ. A. Mirsky: The action of hydrocortisone on the antidiuretic and adrenocorticotrophic responses to noxious stimuli. Endocrinologie64, 955–966 (1959).Google Scholar

Copyright information

© Springer-Verlag 1969

Authors and Affiliations

  • A. Przybylski
    • 1
  1. 1.Centre of Experimental and Clinical MedicinePolish Academy of SciencesWarsawPoland

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