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Relapsing polychondritis with Castleman-like lymphadenopathy: a case report

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Summary

Relapsing Polychondritis (RP) is a systemic disorder characterized by an inflammatory process involving predominantly cartilaginous structures and the cardiovascular system. Lymphadenopathy is a very uncommon finding of RP. We report on a patient affected by RP presenting with lymphadenopathy of Castleman-like type quickly responsive to corticosteroids. The bronchial involvement and the evolution of the inflammatory process in a 3-year follow-up has been documented by computed tomography of the chest.

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References

  1. Herman JH. Polychondritis. In: Kelley WN, Harris ED, Ruddy S, Sledge CB, editors. Textbook of Rheumatology. Philadelphia, Saunders, 1993, 1400–11.

    Google Scholar 

  2. McAdam LP, O'Hanlan MA, Bluestone R, Pearson CM. Relapsing polychondritis: prospective study of 23 patients and a review of the literature. Medicine 1976; 55: 193–215.

    PubMed  Google Scholar 

  3. Frizzera G. Systemic Castleman's disease. Am J Surg Pathol 1991; 15: 192.

    Google Scholar 

  4. Foidart JM, Abe S, Martin GR, Zizic TM, Barnett EV, Lawley TJ, Katz SI. Antibodies to type II collagen in relapsing polychondritis. N Engl J Med 1978; 299: 1203–7.

    PubMed  Google Scholar 

  5. Meyer O, Cyna J, Dryll A, Cywiner-Golenzer C, Wassef M, Ryckewaert A. Relapsing polychondritis. Pathogenic role of anti-native collagen type II antibodies. A case report with immunological and pathological studies. J Rheumatol 1981; 8: 820–4.

    PubMed  Google Scholar 

  6. Svenson KL, Holmdahl R, Klareskog L, Wibell L, Sjoberg O, Klintmalm GB et al. Cyclosporin A treatment in a case of relapsing polychondritis. Scand J Rheumatol 1984; 13: 329–33.

    PubMed  Google Scholar 

  7. Riccieri V, Spadaro A, Taccari E, Zoppini A. A case of relapsing polychondritis: pathogenetic considerations. Clin Exp Rheumatol 1988; 6: 95–6.

    PubMed  Google Scholar 

  8. Alsalameh S, Mollenhauer J, Scheuplein K, Stoss H, Kalden JR, Burkhardt H, et al. Preferential cellular and humoral immune reactivities to native and denaturated collagen types IX and XI in a patient with fatal relapsing polychondritis. J Rheumatol 1993; 20: 1419–24.

    PubMed  Google Scholar 

  9. Gibson GJ. Relapsing polychondritis. In “Lung disease in rheumatic disorders”. Baillière's Clin Rheum 1993; 7: 179–81.

    Google Scholar 

  10. Mendelson DS, Som PM, Crane R, Cohen BA, Spiera H. Relapsing polychondritis studied by computed tomography. Radiology 1985; 157: 489–90.

    PubMed  Google Scholar 

  11. Goddard P, Cook P, Laszlo G, Glover SC. Relapsing polychondritis: report of an unusual case and a review of the literature. Br J Radiol 1991; 64: 1064–7.

    PubMed  Google Scholar 

  12. Miller SB, Donlan CJ, Roth SB. Hodgkin's disease presenting as relapsing polychondritis. Arthritis Rheum 1974; 17: 598–602.

    PubMed  Google Scholar 

  13. Frizzera G, Moran EM, Rappaport H. Angio-Immunoblastic lymphadenopathy. Diagnosis and clinical course. Am J Med 1975; 59: 803–18.

    PubMed  Google Scholar 

  14. Yoshizaki K, Matsuda T, Nishimoto N, Kuritani T, Thaeo L, Aozasa K, et al. Pathogenetic significance of interleukin-6 (IL-6/BSF-2) in Castleman's disease. Blood 1989; 74: 1360–7.

    PubMed  Google Scholar 

  15. Frizzera G. Castleman's Disease: more questions than answers. Hum Pathol 1985; 16: 202–5

    PubMed  Google Scholar 

  16. Isaak BL, Liesegang TJ, Michet CJ Jr. Ocular and systemic findings in relapsing polychondritis. Ophthalmology 1986; 93: 681–9.

    PubMed  Google Scholar 

  17. Michet CJ, McKenna CH, Luthra HS, O'Fallon WM. Relapsing polychondritis. Survival and predictive role of early disease manifestations. Ann Intern Med 1986; 104: 74–8.

    PubMed  Google Scholar 

  18. ter Borg E-J, Piers A, Thijn CJP. Increased cartilaginous uptake on bone scintigraphy in a patient with relapsing polychondritis. Eur J Nucl Med 1988; 14: 427–8.

    Article  PubMed  Google Scholar 

  19. Kao C-H, Wang S-J, Yeh S-H. Radionuclide imaging of relapsing polychondritis. Clin Nucl Med 1992; 17: 397–8.

    PubMed  Google Scholar 

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Authors and Affiliations

  1. From the Rheumatic Disease Unit, Hospital of Parma, Italy

    P. Manganelli

  2. Division of Pulmonary Diseases, Hospital of Parma, Italy

    M. Savini

  3. Department of Internal Medicine, University of Parma, Italy

    F. Quaini M.D.

  4. Department of Pathology, University of Parma, Italy

    G. Olivetti

  5. 2nd Service of Pathology, University of Bologna, Italy

    S. Pileri

Authors
  1. P. Manganelli
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  2. F. Quaini M.D.
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  3. G. Olivetti
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  4. M. Savini
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  5. S. Pileri
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Manganelli, P., Quaini, F., Olivetti, G. et al. Relapsing polychondritis with Castleman-like lymphadenopathy: a case report. Clin Rheumatol 16, 480–484 (1997). https://doi.org/10.1007/BF02238942

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  • DOI: https://doi.org/10.1007/BF02238942

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