Summary
Primary fibromyalgia (PF) has attracted much interest since the 80's. There are many controversies as to whether it is a true disease or not and many studies are carried on. In this study 32 patients which were accepted as PF were examined for some frequent symptoms and allergy and compared with controls. Migraine, irritable bowel syndrome, sleep disturbance and morning stiffness were investigated and found to be 40.6%, 12.5%, 71.9%, 68.8% respectively. Sleep disturbance and morning stiffness showed a positive correlation. Allergy background of PF patients was found frequently when compared with an age and sex matched control group. Though serum IgE levels were found elevated in PF group, they were not statistically significant. Allergic skin tests which could not be performed in the control group, were positive in 10 of 15 PF patients.
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Yunus MB, Masi AT, Calabro JJ, Miller KA, Feigenbaum SL. Primary fibromyalgia (fibrositis): Clinical study of 50 patients with matched normal controls. Semin Arthritis Rheum 1984; 11 (1): 51–171.
Yunus MB. Primary fibromyalgia syndrome: Current concepts. Compr Ther 1984; 10 (8): 21–28.
Bennet RM. Fibrositis: evolution of an enigma. J Rheum 1986; 13 (4): 676–678.
Campbell SM, Clark S, Tindall EA, Forehand ME, Bennet RM. Clinical characteristics of fibrositis. Arthritis Rheum 1983; 26 (7): 817–824.
Smythe HA. Non-articular rheumatism and psychogenic musculoskeletal syndromes. In: McCarty, D.J., editor, Arthritis and Allied Conditions ed. 11. Philadelphia: Lea and Febiger, 1988; 1241–1254.
Moldofsky H, Scarisbrick P, England R. Musculoskeletal symptoms and non REM sleep disturbance in patients with “fibrositis syndrome” and healthy subjects. Psychosom Med 1975; 37: 341–351.
Caro XJ. Immunofluorescent detection of IgG at the dermal epidermal junction in patients with apparent primary fibrositis syndrome. Arthritis Rheum 1984; 27 (10): 1174–79.
Waxman J, Zatzkis SM. Fibromyalgia and menapause. Examination of the relationship. Postgrad Med 1986; 15 (4): 165–7.
Molony RR, McPeek DM, Schiffman D, Frank M, Neubouer A, Schwartzberg M et al. Sleep apnea and the fibromyalgia syndrome. J Rheumatol 1986; 13 (4): 797–800.
Dinerman H, Goldenberg DL, Felson DT. A prospective evaluation of 118 patients with the fibromyalgia syndrome. Prevalence of Raynaud's phenomenon, sicca symptoms, ANA, low complement and Ig deposition at the dermal epidermal junction. J Rheumatol 1986; 13: 368–73.
Yunus MB, Denko CW, Masi AT. Serum beta-endorphin in primary fibromyalgia syndrome: a controlled study. J Rheumatol 1986; 13 (1): 183–6.
Yunus MB, Kalyan-Raman UP, Kalyan-Raman K. Primary fibromyalgia syndrome and myofascial pain syndrome: clinical features and muscle pathology. Arch Phys Med Rehabil 1988; 69 (6): 451–4.
Caro XJ. Is there an immunologic component to the fibrositis syndrome? Rheum Dis Clin North America 1989; 15 (1): 169–86.
Wolfe F, Smythe HA, Yunus MA, Bennet RM, Bombardier C, Goldenberg DL. The American College of Rheumatology 1990 criteria for the classification of fibromyalgia. Report of multicenter criteria committee. Arthritis Rheum 1990; 33 (2): 160–72.
Forslind K, Fredriksson E, Nived O. Does primary fibromyalgia exist? Br J Rheumatol 1990; 29: 368–70.
Wolfe F, Hawley DJ, Cathey MA. Fibrositis: Symptoms frequency and criteria for diagnosis. An evaluation of 291 rheumatic disease patients and 58 normal individuals. J Rheumatol 1985; 12: 1159–63.
Caro XJ, Kinstadt NA, Russel IJ, Wolfe F. Increased sensitivity to health related questions in patients with primary fibrositis syndrome. (Abst.) Arthritis Rheum 1987; 30: S63.
Cleveland CH, Fisher RH, Brestel EP, Esenhart JD, Metzger WJ. Chronic rhinitis: an underrecognised association with fibromyalgia Allergy Proc 1992; 13: (5), 263–7.
Meske-Brand Kapp A, Muller W. Die generalisierte tendomyopathie ein syndrom im rahmen der atopie. Z Rheum 1984; 6: 432–6.
Koenig WC, Powers JJ, Johnson EW. Does allergy play a role in fibrositis? Arch Phys Med Rhabil 1977; 58: 80.
Caro XJ, Wolfe F, Johnston WH, Smith AL. A controlled and blinded study of immunoreactant deposition at the dermal epidermal junction of patients with primary fibrositis syndrome. J Rheumatol 1986; 13 (6): 1086–92.
Schur P. IgG subclasses. A review. Ann Allergy 1987; 58: 89.
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Tuncer, T., Bütün, B., Arman, M. et al. Primary fibromyalgia and allergy. Clin Rheumatol 16, 9–12 (1997). https://doi.org/10.1007/BF02238757
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DOI: https://doi.org/10.1007/BF02238757