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Serum secretory immunoglobulins in ankylosing spondylitis

Clinical Rheumatology volume 15, pages 590–593 (1996)Cite this article

Summary

Humoral mucosal immunity may be implicated in pathophysiology of ankylosing spondylitis (AS). The aim of the study was to evaluate serum levels of IgA, IgM and secretory IgA (sIgA), secretory IgM (sIgM) as well as free secretory component (FSC) in patients with AS compared to controls and rheumatoid arthritis (RA) patients.

Levels of sIgA, sIgM and FSC were measured with a specific ELISA in 37 AS patients, 45 controls and 27 RA. The results were as follows: Serum levels of IgA were higher in AS vs controls and in RA vs controls (p=0.01). Levels of sIgA were higher in AS vs controls (p=0.01), but higher in RA vs AS (p=10−4). There was no difference of sIgM in AS vs controls, FSC levels were higher in AS vs controls, and higher in AS patients with elevated CRP.

In view of elevated FSC, this increase of sIgA in AS may have been due to excessive production of mucosal IgA after bacterial stimulation according to the current hypothesis of the disease.

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References

  1. Wendling, D. Immunopathogénie des spondyloarthropathies. Sem Hôp Paris 1987, 63, 2240–2246.

    Google Scholar 

  2. Calin, A. Spondylarthropathy. In: Oxford Textbook of Rheumatology. Eds.: P.J. Maddison, D.A. Isenberg, P. Woo, D.N. Glass Editors, Oxford Medical Publications 1993, pp. 666–674.

  3. Franssen, M.A.M., Van De Putte L.B.A., Gribnau, F.N.J. IgA serum levels and disease activity in ankylosing spondylitis: a prospective study. Ann Rheum Dis 1985, 44, 766–771.

    PubMed  Google Scholar 

  4. Collado, A., Sanmarti, R., Brancos, M.A., Kanterewicz, E., Gallart, T., Rotes-Querol, J., Cobos, A. Immunoglobulin A and C reactive protein levels in ankylosing spondylitis. Ann Rheum Dis 1987, 46, 719–720.

    PubMed  Google Scholar 

  5. Granfors, K., Toivanen, A. IgA-anti-Yersinia antibodies in Yersinia triggered reactive arthritis. Ann Rheum Dis 1986, 45, 561–565.

    PubMed  Google Scholar 

  6. Sanders, K.M., Hertzman, A., Escobar, M.R., Littman, B.H. Correlation of immunoglobulin and C reactive protein levels in ankylosing spondylitis and rheumatoid arthritis. Ann Rheum Dis 1987, 46, 273–276.

    PubMed  Google Scholar 

  7. Toivanen, A., Lahesmaa-Rantala, R., Vuento, R., Granfors, K. Association of persisting IgA response with Yersinia triggered reactive arthritis: a study on 104 patients. Ann Rheum Dis 1987, 46, 898–901.

    PubMed  Google Scholar 

  8. O'Mahony, S., Anderson, N., Nuki, G., Ferguson, A. Systemic and mucosal antibodies to Klebsiella in patients with ankylosing spondylitis and Crohn's disease. Ann Rheum Dis 1992, 51, 1296–1300.

    PubMed  Google Scholar 

  9. Shodjai-Moradi, F., Ebringer, A., Abuljadayel, I. IgA antibody response to Klebsiella in ankylosing spondylitis measured by immunoblotting. Ann Rheum Dis 1992, 51, 235–237.

    Google Scholar 

  10. Mac Lean, I.L., Archer, J.R., Cawley, M.I.D., Kidd, B.L., O'Hara, B.P., Pegley, F.S., Thompson, P.W. Immune complexes in ankylosing spondylitis. Ann Rheum Dis 1992, 51, 83–86.

    PubMed  Google Scholar 

  11. Jennette, J.C., Ferguson, A.L., Moore, M.A., Freeman, D.G. IgA nephropathy associated with seronegative spondylarthropathies. Arthritis Rheum 1982, 25, 144–149.

    PubMed  Google Scholar 

  12. Collado, A., Sanmarti, R., Bielsa, I., Castel, T., Kanterewicz, E., Canete, J.D., Brancos, M.A., Rotes-Querol. Immunoglobulin A in the skin of patients with ankylosing spondylitis. Ann Rheum Dis 1988, 47, 1004–1007.

    PubMed  Google Scholar 

  13. Wendling, D., Bidet, A., Guidet, M. Intestinal permeability in ankylosing spondylitis. J Rheumatol 1990, 17, 114–115.

    PubMed  Google Scholar 

  14. Mestecky, J., McGhee, J.R. Immunoglobin A (IgA): molecular and cellular interactions involved in IgA biosynthesis and immune response. Adv Immunol 1987, 40, 135–245.

    PubMed  Google Scholar 

  15. Solari, R., Kraehenbuhl, J.P. The biosynthesis of secretory component and its role in the transepithelial transport of IgA dimer. Immunol Today 1985, 6, 17–20.

    Article  Google Scholar 

  16. Vuitton, D.A., Seilles, E., Claude, P., Saya, P., Delacroix, D.L. Gall bladder: the predominant source of bile IgA in man? Clin Exp Immunol 1985, 62, 185–192.

    PubMed  Google Scholar 

  17. Vincent, C., Revillard, J.P. Sandwich-type ELISA for free and bound secretory component in human biological fluids. J Immunol Medhods 1988, 106, 153–160.

    Article  Google Scholar 

  18. Van der Linden, S., Valkenburg, H.A., Cats, A. Evaluation of diagnostic criteria for ankylosing spondylitis. Arthritis Rheum 1984, 27, 361–368.

    PubMed  Google Scholar 

  19. Nashel, D.J., Petrone, D.L., Ulmer, C.C., Sliwinski, A.J. C Reactive Protein: a marker for disease activity in ankylosing spondylitis and Reiter's syndrome. J Rheumatol 1986, 13, 364–367.

    PubMed  Google Scholar 

  20. Bresson-Hadni, S., Rosell, M., Seilles, E., Vuitton, B.A., Guennoune, K., Hory, B., Miguet, J.P., Gillet, M., Vincent C, Revillard, J.P. Serum and bile secretory component during the early post-operative course after liver transplantation. Hepatology 1991, 14, 1046–1053.

    Article  PubMed  Google Scholar 

  21. Hocini, H., Isacki, S., Benlahrache, C., Vitalis, L., Chevalier, X., Larget-Piet, B., Bouvet, J.P. Increased levels of serum IgA as IgA1 monomers in ankylosing spondylitis. Ann Rheum Dis 1992, 51, 790–792.

    PubMed  Google Scholar 

  22. Cowling, P., Ebringer, P., Ebringer, A. Association of inflammation with raised serum IgA in ankylosing spondylitis. Ann Rheum Dis 1980, 39, 545–549.

    PubMed  Google Scholar 

  23. Mackiewicz, A., Van der Linden, S., Reynolds, T.L., Khan, M.A., Kushner, I. Serum IgA, acute phase proteins, and glycosylation alpha-1-acid and glycoprotein in ankylosing spondylitis. Ann Rheum Dis 1989, 48, 99–103.

    PubMed  Google Scholar 

  24. Calguneri, M., Swinburne, L., Shinebaum, R., Cooke, E.M., Wright, V. Secretory IgA: immune defence pattern in ankylosing spondylitis and Klebsiella. Ann Rheum Dis 1981, 40, 600–604.

    PubMed  Google Scholar 

  25. Collado, A., Sanmarti, R., Serra, C., Gallart, T., Canete, J.D., Gratacos, J., Vives, J., Munoz-Gomes, J. Serum levels of secretory IgA in ankylosing spondylitis. Scand J Rheumatol 1991, 20, 153–158.

    Google Scholar 

  26. Mielants, H., Veys, E.M. The gut in the spondyloarthropathies. J Rheumatol 1990, 17, 7–9.

    PubMed  Google Scholar 

  27. Peeters, A.J., Daha, M.R., Smeets, T.J.M., Breedveld, F.C. Bone marrow IgA and IgA subclass synthesis in ankylosing spondylitis. J Rheumatol 1992, 19, 751–753.

    PubMed  Google Scholar 

  28. Wendling, D. Rôle de l'intestin dans la physiopathologie des rhumatismes inflammatoires. Rev Rhum 1992, 59, 389–392.

    PubMed  Google Scholar 

  29. Sartor, R.B. Importance of intestinal mucosal immunity and luminal bacterial cell wall polymers in the aetiology of inflammatory joint diseases. Clin Rheumatol 1989, 3, 223–245.

    Google Scholar 

  30. Jorgensen, C., Bologna, C., Guttierez, M., Anaya, J.M., Reme, T., Sany, J. Serum levels of secretory IgA and in vitro production of IgA in rheumatoid arthritis. Clin Exp Rheumatol 1993, 11, 541–544.1

    PubMed  Google Scholar 

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Affiliations

  1. Professor of Rheumatology, Head, Service de Rhumatologie, Centre Hospitalier Universitaire, Hôpital Jean Minjoz, Boulevard Fleming, 25030, Besançon, France

    D. Wendling

  2. Laboratoire d'Explorations Fonctionnelles Respiratoires, Besançon, France

    J-M. Didier

  3. Laboratoire Universitaire d'Immunologie, Faculté de Médecine et de Pharmacie, Besançon, France

    E. Seilles

Authors
  1. D. Wendling
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  2. J-M. Didier
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  3. E. Seilles
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Wendling, D., Didier, JM. & Seilles, E. Serum secretory immunoglobulins in ankylosing spondylitis. Clin Rheumatol 15, 590–593 (1996). https://doi.org/10.1007/BF02238549

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  • DOI: https://doi.org/10.1007/BF02238549

Key words

  • Ankylosing Spondylitis
  • Secretory Immunoglobulins
  • Mucosal Immunity