Advertisement

Tropical Animal Health and Production

, Volume 11, Issue 1, pp 63–68 | Cite as

Oxfendazole—anthelmintic activity in egyptian goats artificially infected with gastrointestinal nematodes

  • S. A. Michael
  • A. J. Higgins
  • A. H. El Refaii
Article

Summary

The recently developed benzimidazole anthelmintic, oxfendazole, was tested against artificial nematode infestations in Egyptian goats using oral dosing at 4.5 and 2.8 mg/kg. A 100% clearance of mature and immatureHaemonchus contortus, Trichostrongylus axei, Ostertagia circumcincta, Cooperia curticei, Bunostomum trigonocephalum andChabertia ovina was obtained at the 4.5 mg/kg level. Very high levels of clearance against the mature worms were obtained at 2.8 mg/kg but the drug was less effective against immature worms at the lower dose rate. PCV, haemoglobin concentration and total erythrocyte counts declined after infection but became significantly (P<0.001) raised in treated animals.

Keywords

Public Health Dose Orale Dose Rate Veterinary Medicine Benzimidazole 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Oxfendazole—Activite Anthelmintique Chez Des Chevres Infestees Artificiellement Par Voie Orale Avec Des Nematodes Gastrointestinaux (Egypte)

Résumé

L'anthelminthique, Oxfendazole, benzimidazole récemment synthétisé a été testé dans descas d'infestations artificielles à nématodes chez des chèvres egyptiennes, en utilisant une dose orale de 4,5 et 2,8 mg/kg. L'administration de 4,5 mg/kg a permis d'obtenir l'élimination à 100 p.100 deHaemonchus contortus, Trichostrongylus axei, Ostertagia circumcincta, Cooperia curticei, Bunostomum trigonocephalum et deChabertia ovina, adultes et larves. De très hauts niveaux d'élimination des vers adultes ont été atteints à la dose de 2,8 mg/kg mais l'efficacité du produit était moindre en ce qui concerne les larves à cette dernière dose. Le culot cellulaire, la concentration d'hémoglobine et les numérations totales dérythrocytes diminuaient lors de l'infestation mais s'élevaient de façon significative (P<0,001) chez les animaux traités.

Oxfendazole—Actividad Antihelmintica En Cabras Infectadas Artificialmente Con Nematodos Gastrointestinales, En Egipto

Resumen

El recientemente sintetizado antihelmintico benzimidazole, oxfendaxole, se probó en cabras infectadas experimentalmente con nemátodos gastrointestinales. Las dosis utilizadas fueron 4.5 y 2.8 mg/kg de peso. Con la dosis de 4.5 mg/kg de peso, se obtuvo el 100% de efectividad contra larvas y adultos deHaemonchus contortus, Trichostrongilus axei, Ostertagia circumcincta, Cooperia curticei, Bunostomun trigonocephalum yChabertia ovina. La dosis de 2.8 mg/kg de peso, tuvo una buena efectividad contra parásitos adultos, pero fué poco efectiva contras las formas inmaduras. El hematocrito, la hemoglobina y el total de eritrocitos disminuyeron despues de la infección oral, pero aumentaron significativamente despues del tratamiento.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Averkin, E. A., Beard, C. C., Dvorak, C. A., Edwards, J. A., Fried, J. H., Kilian, J. G., Schiltz R. A., Kistner, T. P., Drudge, J. H., Lyons, E. T., Sharp, M. L. &Corwin, R. M. (1975).Journal of Medical Chemistry,18 (11), 1164–1166.Google Scholar
  2. Baker, N. F. &Fisk, R. A. (1977).American Journal of Veterinary Research,38, (9), 1315, 1316.Google Scholar
  3. Chalmers, K. (1977).New Zealand, Veterinary Journal,25 (10), 266–269.Google Scholar
  4. Chalmers, K. (1978).New Zealand Veterinary Journal,26, 162–164.Google Scholar
  5. Coles, E. H. (1974).Veterinary Clinical Pathology, 2nd edn. W. B. Saunders and Co., Philadelphia.Google Scholar
  6. Downey, N. E. (1976).Veterinary Record,99, 267–270.Google Scholar
  7. Downey, N. E. (1977).Veterinary Record,101 (13), 260–263.Google Scholar
  8. Herlich, H. (1956).Proceedings of the Helminthological Society of Washington,23, 102–103.Google Scholar
  9. Leimbacher, F., Nicholas, J. A. &Delahaye, J. (1976).Revue médicale et vétérinaire,127 (6), 941–957.Google Scholar
  10. Round, M. C. (1968).Research In Veterinary Science,9, 583–590.Google Scholar
  11. Schalm, O. W. Jain, N. C. &Carroll, E. J. (1975).Veterinary Haematology, 3rd edn. Lea and Febiger, Philadelphia.Google Scholar
  12. Walley, J. K. (1966).Veterinary Record,78, 406–414.Google Scholar
  13. Wetzel, R. (1957).Tierärztliche Umschau,6, 209–210.Google Scholar

Copyright information

© Longman Group Limited 1979

Authors and Affiliations

  • S. A. Michael
    • 1
  • A. J. Higgins
    • 2
  • A. H. El Refaii
    • 1
  1. 1.Department of ParasitologyAnimal Health Research Institute, Ministry of AgricultureDokki, CairoArab Republic of Egypt
  2. 2.The Wellcome FoundationBerkhamstedUK

Personalised recommendations