The American Journal of Digestive Diseases

, Volume 11, Issue 1, pp 27–39 | Cite as

Pancreatic exocrine function

Comparison of responses to augmented secretin stimulus, augmented pancreozymin stimulus, and test meal in health and disease
  • Richard C. Hartley
  • Earl E. Gambill
  • George W. Engstrom
  • William H. J. Summerskill


The relative value of certain tests of pancreatic exocrine function was assessed by the sequential administration of (1) an augmented dose of secretin, (2) an augmented dose of pancreozymin, and (3) a test meal. Eighty-one individuals were studied—namely, the control group of 47 persons (24 healthy volunteers and 23 patients with nonpancreatic disease) and a group of 34 patients with pancreatic disease. The latter group included 17 patients with chronic pancreatitis: 2 with subacute relapsing pancreatitis and 15 with carcinoma of the pancreas. Measurements of volume, bicarbonate output (peak and total), and bicarbonate concentration (maximal and 60-min.) were made with and without reference to body weight, after administration of secretin. Concentrations and outputs of trypsin and amylase were measured after the administration of pancreozymin and the test meal.

The augmented secretin test yielded the most reliable results, both in indicating pancreatic disease and in differentiating between chronic pancreatitis and pancreatic carcinoma; measurements of volume output per kilogram of body weight, peak or total bicarbonate output, and maximal bicarbonate concentration were the most appropriate data for these purposes. Satisfactory, but less reliable, results were those of secretion that followed the administration of an augmented dose of pancreozymin or a test meal; the findings after these two tests were comparable. Mayo Clinic Rochester, Minn. 55902


Carcinoma Pancreatitis Bicarbonate Trypsin Amylase 
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Copyright information

© Hoeber Medical Division • Harper & Row, Publishers, Incorporated 1966

Authors and Affiliations

  • Richard C. Hartley
    • 1
  • Earl E. Gambill
    • 1
  • George W. Engstrom
    • 1
  • William H. J. Summerskill
    • 1
  1. 1.From the Gastrointestinal Research Unit and the Section of MedicineMayo Clinic and Mayo FoundationRochester

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