Intravenous fat emulsion and gastric secretion in the rat
Intravenous infusions of Intralipid, a soybean oil emulsion, had a dose-related depressant effect on the volume, hydrogenion content, titratable acidity, and acid output of gastric juice secreted by pylorusligated rats. Saline infusions used as volume controls caused significant stimulation of the volume and acid output of gastric secretion, as compared with results in a sham group.
Intralipid infusion was not associated with any acute microscopic mucosal lesions but was followed by obvious arterialfat accumulation not seen in control animals. The cause of the observed gastric secretory depression and its possible relation to the transient accumulations of intra-arterial fat are not known at this time.
KeywordsAcidity Gastric Juice Sham Group Volume Control Hydrogenion Content
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