The American Journal of Digestive Diseases

, Volume 11, Issue 1, pp 1–9 | Cite as

Intravenous fat emulsion and gastric secretion in the rat

  • Peter E. Baume
  • H. C. Meng
  • David H. Law


Intravenous infusions of Intralipid, a soybean oil emulsion, had a dose-related depressant effect on the volume, hydrogenion content, titratable acidity, and acid output of gastric juice secreted by pylorusligated rats. Saline infusions used as volume controls caused significant stimulation of the volume and acid output of gastric secretion, as compared with results in a sham group.

Intralipid infusion was not associated with any acute microscopic mucosal lesions but was followed by obvious arterialfat accumulation not seen in control animals. The cause of the observed gastric secretory depression and its possible relation to the transient accumulations of intra-arterial fat are not known at this time.


Acidity Gastric Juice Sham Group Volume Control Hydrogenion Content 
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Copyright information

© Hoeber Medical Division • Harper & Row, Publishers, Incorporated 1966

Authors and Affiliations

  • Peter E. Baume
    • 1
    • 3
    • 2
  • H. C. Meng
    • 1
  • David H. Law
    • 1
  1. 1.From the Departments of Medicine and PhysiologyVanderbilt University School of MedicineNashville
  2. 2.National Institutes of Health, U. S. Public Health ServiceUSA
  3. 3.Unit of Clinical InvestigationRoyal North Shore HospitalSydneyAustralia

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