Advertisement

The American Journal of Digestive Diseases

, Volume 11, Issue 1, pp 1–9 | Cite as

Intravenous fat emulsion and gastric secretion in the rat

  • Peter E. Baume
  • H. C. Meng
  • David H. Law
Article

Summary

Intravenous infusions of Intralipid, a soybean oil emulsion, had a dose-related depressant effect on the volume, hydrogenion content, titratable acidity, and acid output of gastric juice secreted by pylorusligated rats. Saline infusions used as volume controls caused significant stimulation of the volume and acid output of gastric secretion, as compared with results in a sham group.

Intralipid infusion was not associated with any acute microscopic mucosal lesions but was followed by obvious arterialfat accumulation not seen in control animals. The cause of the observed gastric secretory depression and its possible relation to the transient accumulations of intra-arterial fat are not known at this time.

Keywords

Acidity Gastric Juice Sham Group Volume Control Hydrogenion Content 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Hartwig, Q. L., Cotlar, A. M., Shelby, J. S., Atik, M., andCohn, I. Tolerance to intravenously administered fat emulsions.Surgery 49:308, 1961.Google Scholar
  2. 2.
    Johnson, N. A., Freeman, S., andMeyer, K. Some effects of intravenous fat emulsions on human subjects.J. Lab. & Clin. Med. 39:176, 1952.Google Scholar
  3. 3.
    Shingleton, W. W., Anlyan, W. G., Salem, M. E. H., andSanders, A. P. Studies on intravenous fat emulsions.Surg. Forum 6:18, 1955.Google Scholar
  4. 4.
    Bozian, R. C, Davidson, N. W., Stutman, L. J., andWilkinson, C. F. Observations on the use of intravenous fat emulsions in man.Metabolism 6:703, 1957.Google Scholar
  5. 5.
    Levenson, S. M., Upjohn, H. L., andSheehy, T. W. Two severe reactions following the long term infusion of large amounts of intravenous fat emulsion.Metabolism 6:807, 1957.Google Scholar
  6. 6.
    Cohn, I., Atik, M., andVela, A. R. “Investigation of Intravenous Fat Emulsions.”Proceedings of a Conference on Fat Emulsion for Intravenous Nutrition. Ed., by Meng, H. C., Office of the Surgeon General, Dept. of the Army, Washington, D. C., 1963, p. 36.Google Scholar
  7. 7.
    Shay, H., Sun, D. C. H., andGruenstein, M. A quantitative method for measuring spontaneous gaestric secretion in the rat.Gastroenterology 26:906, 1954.Google Scholar
  8. 8.
    Bralow, S. P., andKomarov, S. A. Parietal cell mass and distribution in stomachs of Wistar rats.Am. J. Physiol. 203:550, 1962.Google Scholar
  9. 9.
    James, A. H. Clinical assessment of gastric function.Proc. Roy. Soc. Med. 55:71, 1962.Google Scholar
  10. 10.
    Dixon, W. J., andMassey, F. J. Introduction to Statistical Analysis (ed. 2). McGraw-Hill, New York, 1957, p. 290.Google Scholar
  11. 11.
    Villareal, R., Robertson, C., andGrossman, M. I. Stimulation of gastric secretion in dogs by parenterally administered fluids.Am. J. Physiol. 169:757, 1952.Google Scholar
  12. 12.
    Wilkins, D. J. Rapid appearance of injected fat in the gut of the rat.Proc. Soc. Exper. Biol. & Med. 112:953, 1963.Google Scholar
  13. 13.
    Geyer, R. P. “Studies on the Excretion via Bile of Intravenously Infused Fat and Emulsion Ingredients.”Proceedings of a Conference on Fat Emulsion for Intravenous Nutrition. Ed. by Meng, H. C., Office of the Surgeon General, Dept. of the Army, Washington, D. C., 1963, p. 14.Google Scholar
  14. 14.
    Meng, H. C. Removal of intravenously injected fat from the circulation and its appearance in thoracic duct lymph.Am. J. Physiol. 168:335, 1952.Google Scholar
  15. 15.
    Jacobson, E. D., Scott, J. B., andFrohlich, E. D. Haemodynamics of the stomach. II. Relation between gaestric secretion and blood flow.Am. J. Digest. Dis. 9:786, 1962.Google Scholar
  16. 16.
    Levine, R. A. “Hemodynamic Changes Produced by Artificial Fat Emulsions in Isolated Perfused Rat Liver.”Proceedings of a Conference on Fat Emulsion for Intravenous Nutrition. Ed. by Meng, H. C., Office of the Surgeon General, Dept. of the Army, Washington, D. C., 1963, p. 48.Google Scholar
  17. 17.
    Baronofsky, I., Meredino, K. A., Bratud, T. E., andWangensteen, O. H. Fate of intravenously injected fat: it role in the production of ulcer.Proc. Soc. Exper. Biol. & Med. 59:231, 1945.Google Scholar

Copyright information

© Hoeber Medical Division • Harper & Row, Publishers, Incorporated 1966

Authors and Affiliations

  • Peter E. Baume
    • 1
    • 3
    • 2
  • H. C. Meng
    • 1
  • David H. Law
    • 1
  1. 1.From the Departments of Medicine and PhysiologyVanderbilt University School of MedicineNashville
  2. 2.National Institutes of Health, U. S. Public Health ServiceUSA
  3. 3.Unit of Clinical InvestigationRoyal North Shore HospitalSydneyAustralia

Personalised recommendations