Skip to main content
Log in

Carbohydrate metabolism studies in cirrhosis of the liver

  • Published:
The American Journal of Digestive Diseases Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Hed, R. Clinical studies in chronic alcoholism: II. Carbohydrate metabolism in chronic alcoholism with particular reference to glucose and insulin tolerance.Acta Med Scand 162:195, 1958.

    PubMed  Google Scholar 

  2. Creutzfeldt, W., Wille, K., andKaup, H. Intravenöse Belastung mit Glucose, Insulin and Tolbutamide bei Gesunden, Diabetikern, Leberzirrhotikern und Insulomträgern.Deutsch Med Wschr 87:2189, 1962.

    PubMed  Google Scholar 

  3. Berkowitz, D., andGlassman, S. Response of blood sugar and unesterified fatty acids to oral glucose and intravenous tolbutamide and glucagon in normal subjects and patients with cirrhosis, (abst).Gastroenterology 44:816, 1963.

    Google Scholar 

  4. Justin-Besancon, L., Pequignot, H., Etienne, J. P., Deuil, R., andPetite, J. P. Les troubles de la glyciregulation des cirrhotiques.Sem Hop Paris 42:2605, 1966.

    PubMed  Google Scholar 

  5. Müting, D., Lackas, N., Reikowski, H., andRichmond, S. Cirrhosis of the liver and diabetes mellitus.German Med Monthly 11:385, 1966.

    Google Scholar 

  6. Meillinkoff, S. N., andTumulty, P. A. Hepatic hypoglycemia, its occurrence in congestive cardiac failure.New Eng J Med 247:745, 1952.

    PubMed  Google Scholar 

  7. Cohn, H. J., Perlmutter, M., Silverstein, J. N., andNumsroff, M. Prolonged hypoglycemia in response to intravenous tolbutamide in a patient with Laennec's cirrhosis and severe malnutrition.J Clin Endocr 24:28, 1964.

    PubMed  Google Scholar 

  8. Marks, V., andRose, F. C. Hypoglycemia. Blackwell, Oxford, 1965, p. 166.

    Google Scholar 

  9. Krall, L. P. When is diabetes?Med Clin N Amer 49:893, 1965.

    PubMed  Google Scholar 

  10. Fajans, S. S., Schneider, J. M., Schteingart, D. E., andConn, J. W. The diagnostic value of sodium tolbutamide in hypoglycemic states.J Clin Endocr 21:371, 1961.

    PubMed  Google Scholar 

  11. Hoffman, W. S. Rapid photoelectric method for determination of glucose in blood and urine.J Biol Chem 120: 51, 1937.

    Google Scholar 

  12. Streeten, D. H. P., Gerstein, M. M., Marmor, B. M., andDoisy, R. J. Reduced glucose tolerance in elderly human subjects.Diabetes 14:579, 1965.

    PubMed  Google Scholar 

  13. Unger, R. H., andMadison, L. L. Comparison of response to intravenous sodium tolbutamide in mild diabetic and non-diabetic subjects.J Clin Invest 37:627, 1958.

    PubMed  Google Scholar 

  14. Creutzfeldt, W. C., Frerichs, H., andKraft, W. The intravenous tolbutamide test in liver disease.Acta Diabet Latina 4:205, 1967.

    Google Scholar 

  15. Van Itallie, T. B., andBentley, W. B. Glucagon-induced hyperglycemia as an index of liver function.J Clin Invest 34:1730, 1955.

    PubMed  Google Scholar 

  16. Cerletty, J. M., andEngbring, N. H. Azotemia and glucose intolerance.Ann Intern Med 66:1097, 1967.

    PubMed  Google Scholar 

  17. Tchobroutsky, C, Collin de L'Hortet, G., Rosselin, G., Assan, H., andDerot, M. Étude dc la glycoregulation dans l'insuffisance rénale chroniquc I.Diabelologia 1:101, 1965.

    Google Scholar 

  18. Shear, L., Kleinerman, J., andGabzuda, G. J. Reual failure in patients with cirrhosis of the liver: I. Clinical and pathologic characteristics.Amer J Med 39:184, 1965.

    Article  PubMed  Google Scholar 

  19. Marks, P. A., andBishop, J. S. The glucose metabolism of patients with malignant disease and of normal subjects as studied by means of an intravenous glucose tolerance test.J Clin Invest 36:254, 1957.

    PubMed  Google Scholar 

  20. Sagild, U., Andersen, V., andAndreasen, P. B. Glucose tolerance and insulin responsiveness in experimental potassium depletion.Acta Med Scand 169:243, 1961.

    PubMed  Google Scholar 

  21. Breckenbridge, A., Welborn, T. A., Dollery, C. T., andFrazer, R. Glucose tolerance in hypertensive patients on long-term diuretic therapy.Lancet 1:61, 1967.

    Article  PubMed  Google Scholar 

  22. Andersen, O. O., andFriis, T. The intravenous tolbutamide test in diagnosing mild and latent diabetes mellitus.Acta Med Scand 181:535, 1967.

    PubMed  Google Scholar 

  23. Freinkel, N., Singer, D. L., Arky, R. A., Bleicher, S. J., Anderson, J. B., andSilbert, C. K. Alcohol hypoglycemia: I. Carbohydrate metabolism of patients with clinical alcohol hypoglycemia and the experimental reproduction of the syndrome with pure ethanol.J Clin Invest 42:1112, 1963.

    Google Scholar 

  24. Carneiro de Moura, M., Pinto Correia, J., andMadeira, F. Clinical alcohol hypoglycemia.Ann Intern Med 66:893, 1967.

    PubMed  Google Scholar 

  25. Carneiro de Moura, M. Unpublished data.

  26. Kahil, M. E., Cashaw, J., Simons, E. L., andBrown, H. Alcohol and the tolbutamide response in the dog.J Lab Clin Med 64:808, 1964.

    PubMed  Google Scholar 

  27. Samaan, N., Stillman, D., andFrazer, R. Abnormalities of serum insulin-like activity on liver disease.Lancet 2:1287, 1962.

    Article  PubMed  Google Scholar 

  28. Hales, C. N., andRandle, P. J. Effects of low-carbohydrate diet and diabetes mellitus on plasma concentrations of glucose, non-esterified fatty acid, and insulin during oral-glucose tolerance tests.Lancet 1:790, 1963.

    Article  PubMed  Google Scholar 

  29. Randle, P. J., Garland, P. B., Hales, C. N., andNewsholme, E. A. The glucose fatty-acid cycle.Lancet 1:785, 1963.

    Article  PubMed  Google Scholar 

  30. Schalch, D. S., andKipnis, D. M. Abnormalities in carbohydrate tolerance associated with elevated plasma non-esterified fatty acids.J Clin Invest 44:2010, 1965.

    PubMed  Google Scholar 

  31. Kopetz, K., Bottermann, P., Eymer, K. P., andSchwarz, K. Untersuchungen uber den Fettsffwechsel bei Lebercirrhosen nach Glucose-und Tolbutamidbelastung.Verh Deutsch Ges Inn Med 71:762, 1965.

    Google Scholar 

  32. Lang, S., Goldstein, M. S., andLevine, R. Influence of liver on uptake of glucose by extrahepatic tissues.Amer J Physiol 177:447, 1954.

    PubMed  Google Scholar 

  33. McIntyre, N., Holdsworth, C. D., andTurner, D. S. Intestinal factors in the control of insulin secretion.J Clin Endocr 25:1317, 1965.

    PubMed  Google Scholar 

  34. Megyesi, C., Samols, E., andMarks, V. Glucose tolerance and diabetes in chronic liver disease.Lancet 2:1051, 1967.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Additional information

We wish to thank Professor F. Madeira for advice during the course of this study and for a critical review of the manuscript. The technical assistance of Dr. Fernando Barros, Chief, Biochemistry Laboratory, Santa Maria Hospital, is gratefully acknowledged, as well as the invaluable cooperation of Sisters Maria Luisa and Lidia.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Moura, M.C.d., Cruz, A.G. Carbohydrate metabolism studies in cirrhosis of the liver. Digest Dis Sci 13, 891–906 (1968). https://doi.org/10.1007/BF02237575

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02237575

Keywords

Navigation