The effect of secretin on gastric Acid secretion and peptic ulcers induced by pentagastrin in cats with intact or resected duodenum
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A study was carried out on cats prepared with gastric fistulas and divided in two groups: A, with duodenum left in normal position; and B, with duodenum resected and bile and pancreatic juice diverted to the upper jejunum.
Acid secretion under basal conditions and in the response to graded doses of pentagastrin and peptic ulcers produced by a constant intravenous infusion of pentagastrin have been studied before and after secretin intravenous infusion in doses of 2 or 4 U./kg./hr. throughout the experiments.
Secretin infusion resulted in basal achlorhydria in both groups of animals and in the reduction of acid outputs induced by lower doses of pentagastrin in cats with intact duodenum. Maximal acid output in animals both with intact and resected duodenum was not altered by secretin infusion.
Secretin infused in a dose of 2 U./kg./hr. completely prevented the production of peptic ulcers in animals both with intact and removed duodenum.
It is assumed that alkalinization of the intestinal mucosa by secretin was the major factor in the prevention of the production of peptic ulcers by pentagastrin in cats.
KeywordsPublic Health Peptic Ulcer Gastric Acid Intravenous Infusion Acid Secretion
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