The American Journal of Digestive Diseases

, Volume 13, Issue 10, pp 874–881 | Cite as

The effect of secretin on gastric Acid secretion and peptic ulcers induced by pentagastrin in cats with intact or resected duodenum

  • Stanislaw J. Konturek


A study was carried out on cats prepared with gastric fistulas and divided in two groups: A, with duodenum left in normal position; and B, with duodenum resected and bile and pancreatic juice diverted to the upper jejunum.

Acid secretion under basal conditions and in the response to graded doses of pentagastrin and peptic ulcers produced by a constant intravenous infusion of pentagastrin have been studied before and after secretin intravenous infusion in doses of 2 or 4 U./kg./hr. throughout the experiments.

Secretin infusion resulted in basal achlorhydria in both groups of animals and in the reduction of acid outputs induced by lower doses of pentagastrin in cats with intact duodenum. Maximal acid output in animals both with intact and resected duodenum was not altered by secretin infusion.

Secretin infused in a dose of 2 U./kg./hr. completely prevented the production of peptic ulcers in animals both with intact and removed duodenum.

It is assumed that alkalinization of the intestinal mucosa by secretin was the major factor in the prevention of the production of peptic ulcers by pentagastrin in cats.


Public Health Peptic Ulcer Gastric Acid Intravenous Infusion Acid Secretion 
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  1. 1.
    Brauch, C. M., Brave, J., Dragstedt, L. R., II, Dragstedt, L. R. Pathogenesis of Exalto-Mann-Williamson ulcer: II. Relation of antrum to hypersecretion of gastric juice in Mann-Williamson animals.Gastroenterology 39: 330, 1960.PubMedGoogle Scholar
  2. 2.
    Cooke, A. R. Comparison of acid and pepsin outputs from gastric fistula dogs in response to histamine, gastrin, and related peptides.Gastroenterology 55:579, 1967.Google Scholar
  3. 3.
    Emas, S., Billigs, A., andGrossman, M. I. Effects of gastrin and pentagastrin on gastric and pancreatic secretion in dogs.Gut (In press)Google Scholar
  4. 4.
    Fisher, R. A. Statistical Methods for Research Workers (ed. 13). Hafner Inc., New York, 1958.Google Scholar
  5. 5.
    Grossman, M. I. Treatment of duodenal ulcer with secretin: A speculative proposal.Gastroenterology 50: 912, 1966.PubMedGoogle Scholar
  6. 6.
    Johnson, L. R., andGrossman. M. I. Secretin: The enterogastrone released by acid in the duodenum.Amer J Physiol (In press)Google Scholar
  7. 7.
    Konturek, S. J., andGrossman, M. I. Acid response to gastrin and related peptides.Gastroenterology 50: 650, 1966.PubMedGoogle Scholar
  8. 8.
    Konturek, S. J., andKról, W. The influence of gastrin-related peptides on HC1 secretion in man and in cats with gastric fistulas and Heideuhain pouches.Gastroenterologia (Basel) 106:281, 1966.PubMedGoogle Scholar
  9. 9.
    Konturek, S. J., andDubiel, J. Effect of diversion of bile and pancreatic juice on pentagastrin produced duodenal ulcers in cats.Scand J Gastroent (In press)Google Scholar
  10. 10.
    Konturek, S. J., Dubiel, J., andGabrys, B. The effect of exclusion, acidification and excision of duodenum on gastric acid secretion and the production of pentagastrin-produced peptic ulers in cats. Unpublished data.Google Scholar
  11. 11.
    Morley, S. J., Tracy, H. J., andGregory, R. A. Structure-function relationship in the active C-terminal tetra-peptide sequence of gastrin.Nature (London) 207:1356, 1965.PubMedGoogle Scholar
  12. 12.
    Stauffer, M. H., andHallenbeck, G. A. “The Mann-Williamson ulcer.” InPathophysiology of Peptic Ulcer. Soryna, S. C, Ed. Lippincott, Philadelphia, 1963.Google Scholar
  13. 13.
    Stening, G. F., andGrossman, M. I. The effect of secretin on Brunner's gland secretion.Nature (London) (In press)Google Scholar
  14. 14.
    Vagne, M., Stening, G. F., Brooks, T. P., andGrossman, M. I. Synthetic secretin: Comparison with natural secretin for potency and spectrum of physiological actions.Gastroenterology (In press)Google Scholar
  15. 15.
    Wormsley, K. G., andGrossman, M. I. Inhibition of gastric acid secretion by secretion and by endogenous acid in the duodenum.Gastroenterology 47:72, 1964.PubMedGoogle Scholar

Copyright information

© Hoeber Medical Division • Harper & Row, Publishers, Incorporated 1968

Authors and Affiliations

  • Stanislaw J. Konturek
    • 1
  1. 1.From the I Department of MedicineMedical SchoolKrakowPoland

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