Abstract
PURPOSE: This study was designed to investigate the protective effect of a pedunculated seromuscular flap on intestinal anastomosis after corticosteroid treatment. METHODS: Forty male Sprague-Dawley rats were divided into four groups, and all animals underwent intestinal anastomosis. Two groups, with or without seromuscular flap wrapping, received 5 mg cortisone acetate, and two groups received placebo (saline) preoperatively for 16 days. Anastomotic strength was defined as bursting pressure (in millimeters of mercury). The pedunculated seromuscular flap was prepared from a segment of intestine next to the anastomosis. Intestinal bursting strength at the anastomotic site was measured at Postoperative Day 8. RESULTS: The anastomotic bursting strength was significantly lower in the steroid groups at Postoperative Day 8 (P<0.01). The pedunculated seromuscular flap increased the strength of the anastomosis both in the steroid and control groups (P<0.05). CONCLUSION: The adverse effect of corticosteroids on intestinal anastomoses may be prevented by a pedunculated seromuscular flap.
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Yol, S., Yol, S., Tavli, Ş. et al. Effect of pedunculated seromuscular flap on bursting strength of intestinal anastomosis after corticosteroid treatment. Dis Colon Rectum 43, 987–990 (2000). https://doi.org/10.1007/BF02237365
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DOI: https://doi.org/10.1007/BF02237365