Diseases of the Colon & Rectum

, Volume 43, Issue 7, pp 971–975 | Cite as

Prognostic influence of p53 nuclear overexpression in colorectal carcinoma

  • M. Galindo Gallego
  • M. J. Fernández Aceñero
  • J. Sanz Ortega
  • A. Aljama Delgado
  • J. L. Balibrea Cantero
Original Contributions
  • 15 Downloads

Abstract

PURPOSE: The aim of this study was to test the prognostic influence of p53 nuclear overexpression in colorectal carcinoma. METHODS: We performed an analysis of the prognostic influence of the nuclear overexpression of p53 with immunohistochemistry in 126 cases of colorectal carcinoma operated on in our hospital between 1987 and 1992, with a minimum follow-up time of 60 months (5 years). RESULTS: Our results show a statistically significant prognostic influence of p53 overexpression on disease-free survival time, but not on the overall survival time, in univariate analysis, but this influence is lost in multivariate analysis. CONCLUSIONS: Our results confirm recent reports by other authors that failed to show the independent prognostic value of p53 in colorectal carcinoma.

Key words

Colorectal carcinoma p53 Prognosticators 

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References

  1. 1.
    De Vita VT, Hellman S, Rosemberg SA. Cancer. Principles and practice of oncology. 4th ed. Philadelphia: JB Lippincott, 1993:923.Google Scholar
  2. 2.
    Morris DL. Colorectal neoplasia: epidemiology and aetiology. Curr Opin Gastroenterol 1990;6:24–32.Google Scholar
  3. 3.
    Patel SC, Toveee EB, Langer B. Twenty-five years of experience with radical surgical treatment of carcinoma of the extraperitoneal rectum. Surgery 1977;82:460–5.Google Scholar
  4. 4.
    Linzer DI, Levine AJ. Characterization of a 54k dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells. Cell 1979;17:43–52.Google Scholar
  5. 5.
    Nigro JM, Baker SJ, Preisinger AC,et al. Mutations in the p53 gene occur in diverse human tumour types. Nature 1989;342:705–8.Google Scholar
  6. 6.
    Vogelstein B, Kinzler KW. p53 function and dysfunction. Cell 1992;70:523–6.Google Scholar
  7. 7.
    Lane DP. p53, guardian of the genome. Nature 1992;358:15–6.Google Scholar
  8. 8.
    Silvestrini R, Benini E, Daidone MG,et al. p53 as an independent prognostic marker in lymph nodenegative breast cancer patients. J Natl Cancer Inst 1993;85:965–70.Google Scholar
  9. 9.
    Quinlan DC, Davidson AG, Summers CL, Warden HE, Doshi HM. Accumulation of p53 protein correlates with poor prognosis in human lung cancer. Cancer Res 1992;52:4828–31.Google Scholar
  10. 10.
    Ebina M, Steinberg SM, Mulshine JL, Linnoila RI. Relationships of p53 overexpression and up-regulation of proliferating cell nuclear antigen with the clinical course of non-small cell lung cancer. Cancer Res 1994;54:2496–503.Google Scholar
  11. 11.
    Uhlman DL, Nguyen PL, Manivel JC,et al. Association of immunohistochemical staining for p53 with metastatic progression and poor survival in patients with renal cell carcinoma. J Natl Cancer Inst 1994;86:1470–5.Google Scholar
  12. 12.
    Sarkis SA, Dalbagni G, Gordon Cardo C,et al. Association of p53 nuclear overexpression and tumor progression in carcinoma in situ of the bladder. J Urol 1994;152:388–92.Google Scholar
  13. 13.
    Ito K, Watanabe K, Nasim S,et al. Prognostic significance of p53 overexpression in endometrial cancer. Cancer Res 1994;54:4667–70.Google Scholar
  14. 14.
    Henriksen R, Strang P, Wilander E,et al. p53 expression in epithelial ovarian neoplasms: relationship to clinical and pathological parameters, Ki-67 expression and flow cytometry. Gynecol Oncol 1994;53:301–6.Google Scholar
  15. 15.
    Joypaul BV, Hopwood D, Newman EL,et al. The prognostic significance of the accumulation of p53 tumor-suppressor gene protein in gastric adenocarcinoma. Br J Cancer 1994;69:943–6.Google Scholar
  16. 16.
    Fernandez-Aceñero MJ, Galindo M, Aragoncillo P, Fariña J. Vascular enumeration as a prognosticator for invasive breast carcinoma. J Clin Oncol 1998;16:1684–8.Google Scholar
  17. 17.
    Kawai A, Noguchi M, Beppu Y,et al. Nuclear immunoreaction of p53 protein in soft tissue sarcomas: a possible prognostic factor. Cancer 1994;73:2499–505.Google Scholar
  18. 18.
    Zhang ZF, Zhang ZS, Sarkis AS,et al. Family history of cancer, body weight, and p53 overexpression in Duke's C colorectal cancer. Br J Cancer 1995;71:888–93.Google Scholar
  19. 19.
    Sjögren S, Inganas M, Norberg T,et al. The p53 gene in breast cancer; prognostic value of complementary DNA sequencing versus immunohistochemistry. J Natl Cancer Inst 1996;88:173–82.Google Scholar
  20. 20.
    Scott N, Sagar P, Stewart J, Blair GE, Dixon MF, Quirke P. p53 in colorectal cancer: clinicopathological correlation and prognostic significance. Br J Cancer 1991;63:317–9.Google Scholar
  21. 21.
    Yamaguchi A, Kurosaka Y, Fushida S,et al. Expression of p53 protein in colorectal cancer and its relationship to short-term prognosis. Cancer 1992;70:2778–84.Google Scholar
  22. 22.
    Zeng ZS, Sarkis AS, Zhang ZF,et al. p53 nuclear overexpression: an independent predictor of survival in lymph node-positive colorectal cancer patients. J Clin Oncol 1994;12:2043–50.Google Scholar
  23. 23.
    Takahashi Y, Bucana CD, Cleary KR, Ellis LM. p53, vessel count and vascular endothelial growth factor expression in human colon cancer. Int J Cancer 1998;79:34–8.Google Scholar
  24. 24.
    Manne U, Myers RB, Moron C,et al. Prognostic significance of Bcl-2 expression and p53 nuclear accumulation in colorectal adenocarcinoma. Int J Cancer 1997;74:346–58.Google Scholar
  25. 25.
    Mulder JW, Baas IO, Polak MM,et al. Evaluation of p53 protein expression as a marker for long-term prognosis in colorectal carcinoma. Br J Cancer 1995;71:1257–62.Google Scholar
  26. 26.
    Manne U, Weiss HL, Myers RB,et al. Nuclear accumulation of p53 in colorectal adenocarcinoma: prognostic importance differs with race and location of the tumor. Cancer 1998;83:2456–67.Google Scholar
  27. 27.
    Sun XF, Carstenser JM, Stal O,et al. Prognostic significance of cytoplasmic p53 oncoprotein in colorectal adenocarcinoma. Lancet 1992;340:1369–73.Google Scholar
  28. 28.
    Tollenaar RA, van Krieken JH, van Slooten HJ,et al. Immunohistochemical detection of p53 and Bcl-2 in colorectal carcinoma: no evidence for prognostic significance. Br J Cancer 1998;77:1842–7.Google Scholar
  29. 29.
    Chen YT, Henk MJ, Carney KJ,et al. Prognostic significance of tumor markers in colorectal cancer patients: DNA index, S-phase fraction, p53 expression, and Ki-67 index. J Gastrointest Surg 1997;1:266–73.Google Scholar
  30. 30.
    Pereira H, Silva S, Juliao R, Garcia P, Perpetua F. Prognostic markers for colorectal cancer: expression of p53 and Bcl2. World J Surg 1997;21:210–3.Google Scholar
  31. 31.
    Nathanson SD, Linden MD, Tender P, Zarbo RJ, Jacobsen G, Nelson LT. Relationship among p53, stage and prognosis of large bowel cancer. Dis Colon Rectum 1994;37:527–34.Google Scholar
  32. 32.
    Sun XF, Carstenser JM, Stal O,et al. Prognostic significance of p53 expression in relation to DNA ploidy in colorectal adenocarcinoma. Virchows Arch A Pathol Anal Histopathol 1993;423:443–8.Google Scholar
  33. 33.
    Flamini G, Curigliano G, Ratto C,et al. Prognostic significance of cytoplasmic p53 overexpression in colorectal cancer. An immunohistochemical analysis. Eur J Cancer 1996;32:802–6.Google Scholar
  34. 34.
    Wu X, Boyle JH, Olson DC, Levine AJ. The p53-mdm2 autoregulatory feed-back loop. Genes Dev 1993;7:1126–32.Google Scholar
  35. 35.
    Prioleau J, Schnitt SJ. p53 antigen loss in stored paraffin slides. N Engl J Med 1995;22:1521–2.Google Scholar

Copyright information

© The American Society of Colon and Rectal Surgeons 2000

Authors and Affiliations

  • M. Galindo Gallego
    • 1
  • M. J. Fernández Aceñero
    • 2
  • J. Sanz Ortega
    • 3
  • A. Aljama Delgado
    • 2
  • J. L. Balibrea Cantero
    • 4
  1. 1.From the Hospital de la FuenfríaCercedilla
  2. 2.Department of Surgical PathologyHospital de MóstolesMadridSpain
  3. 3.Department of Surgical PathologyHospital Clínico de MadridMadridSpain
  4. 4.Department of SurgeryHospital Clínico de MadridMadridSpain

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