Regression of rectal stenosis secondary to neoplasm in an HIV1-Positive patient with gancyclovir antiviral therapy
PURPOSE: The case of a human immunodeficiency viruspositive patient with rectal stenosis caused by a tumor that completely regressed in response to gancyclovir is presented. METHODS: Several biopsies from the tumoral mass failed to show any stigmata of non-Hodgkin's lymphoma, adenocarcinoma, or Kaposi sarcoma. No parasites could be detected in rectal biopsies. Viral inclusions showing both Epstein-Barr virus and cytomegalovirus on immunostained sections suggested an unusual form of viral infection. RESULTS: Antiviral therapy (gancyclovir 10 mg/kg/day) had a dramatic effect on pain and discharge of blood, and suppressed rectal difficulties within three days of therapy. The antiviral treatment was stopped at Day 10 because of leukopenia. Endoscopic and histologic examinations revealed normal rectal mucosa after 3, 6, 9, 12, and 18 months of follow-up. CONCLUSION: This is the first case of complete and long-term regression of a rectal stenosis secondary to a tumoral mass in response to antiviral therapy in patients with human immunodeficiency virus.
Key wordsRectal tumor Human immunodeficiency virus Acquired immunodeficiency syndrome Cytomegalovirus Epstein-Barr virus Gancyclovir
Unable to display preview. Download preview PDF.
- 3.Subar MI. Gastrointestinal and nutritional manifestations of AIDS. In: Kotler DO, ed. Gastrointestinal neoplasms in AIDS. New York: Raven Press, Ltd. 1991:93–117.Google Scholar
- 4.Anonymes. Réseau National de Santé. Surveillance du SIDA en France. Bull Epidemiol Hebd 1996;10:45–50.Google Scholar
- 5.Friedman SC. Kaposi's sarcoma and lymphoma of the gut in AIDS. In: Bailliere's clinical gastroenterology. Saunders BP ed. London: Bailliere-Tindall, 1990:455–75.Google Scholar