Diseases of the Colon & Rectum

, Volume 41, Issue 11, pp 1454–1457 | Cite as

Regression of rectal stenosis secondary to neoplasm in an HIV1-Positive patient with gancyclovir antiviral therapy

Report of a case
  • Iradj Sobhani
  • Babak Mirin Babazadeghan
  • Anne-Marie Francey
  • Christiane Vissuzaine
  • Bruno Fantin
  • Agnès Villemant
  • Emmanuelle Navratil
  • Michel Mignon
Case Reports
  • 11 Downloads

Abstract

PURPOSE: The case of a human immunodeficiency viruspositive patient with rectal stenosis caused by a tumor that completely regressed in response to gancyclovir is presented. METHODS: Several biopsies from the tumoral mass failed to show any stigmata of non-Hodgkin's lymphoma, adenocarcinoma, or Kaposi sarcoma. No parasites could be detected in rectal biopsies. Viral inclusions showing both Epstein-Barr virus and cytomegalovirus on immunostained sections suggested an unusual form of viral infection. RESULTS: Antiviral therapy (gancyclovir 10 mg/kg/day) had a dramatic effect on pain and discharge of blood, and suppressed rectal difficulties within three days of therapy. The antiviral treatment was stopped at Day 10 because of leukopenia. Endoscopic and histologic examinations revealed normal rectal mucosa after 3, 6, 9, 12, and 18 months of follow-up. CONCLUSION: This is the first case of complete and long-term regression of a rectal stenosis secondary to a tumoral mass in response to antiviral therapy in patients with human immunodeficiency virus.

Key words

Rectal tumor Human immunodeficiency virus Acquired immunodeficiency syndrome Cytomegalovirus Epstein-Barr virus Gancyclovir 

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Copyright information

© The American Society of Colon and Rectal Surgeons 1998

Authors and Affiliations

  • Iradj Sobhani
    • 1
  • Babak Mirin Babazadeghan
    • 1
  • Anne-Marie Francey
    • 1
  • Christiane Vissuzaine
    • 2
  • Bruno Fantin
    • 3
  • Agnès Villemant
    • 3
  • Emmanuelle Navratil
    • 4
  • Michel Mignon
    • 1
  1. 1.From the Department of GastroenterologyBichat HospitalParisFrance
  2. 2.Department of PathologyBichat HospitalParisFrance
  3. 3.Department of Internal MedicineBichat HospitalParisFrance
  4. 4.the Department of PathologyBeaujon HospitalClichyFrance

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