The American Journal of Digestive Diseases

, Volume 10, Issue 2, pp 122–127 | Cite as

Effect of histamine on the protein and mucus content of gastric juice

  • D. W. Piper
  • F. L. Broderick
  • Barbara H. Fenton
  • Deborah Beeston


1. Histamine causes a fall in the concentration of both protein and mucus in gastric juice; the stimulatory effect of histamine on the volume of secretion, however, results in a marked rise in output of protein and a less marked rise in the output of mucus.

2. The effect of histamine is more marked on protein secretion than on mucus secretion, and the rise in output of protein cannot be explained by the effect on mucus secretion.


Public Health Histamine Gastric Juice Protein Secretion Mucus Secretion 
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  1. 1.
    Riddell, M. T., Strong, J. A., andCameron, D. The electrolyte concentration of human gastric secretion.Quart. J. Exp. Physiol. 45:1, 1960.Google Scholar
  2. 2.
    Milton, G. W., Skyring, A. P., andGeorge, E. P. Histamine secretory tests in cats: an evaluation of results based upon Hollander's two-component theory.Gastroenterology 44:642, 1963.Google Scholar
  3. 3.
    Piper, D. W. The effect of histamine on pepsin secretion.Am. J. Dig. Dis. 5:880, 1960.CrossRefPubMedGoogle Scholar
  4. 4.
    Kay, A. W. Effect of large doses of histamine on gastric secretion of HCl.Brit. Med. J. 2:77, 1953.PubMedGoogle Scholar
  5. 5.
    Gornall, A. G., Bardawill, C. J., andDavid, M. M. Determination of serum proteins by means of biuret reaction.J. Biol. Chem. 277:751, 1949.Google Scholar
  6. 6.
    Richmond, V., Caputto, R., andWolf, S. Fractionation of the non dialyzable soluble compounds of gastric content by chromatography on Amberlite IRC-56.Arch. Biochem. 66:155, 1957.CrossRefPubMedGoogle Scholar
  7. 7.
    Warren, L. The thiobarbituric acid assay of sialic acid.J. Biol. Chem. 234:197, 1959.Google Scholar
  8. 8.
    Dische, Z., andShettles, L. B. A specific color reaction of methyl pentoses and a spectrophotometric micro-method for their determination.J. Biol. Chem. 175: 595, 1948.Google Scholar
  9. 9.
    Babkin, B. P. The value of histamine as a test of gastric secretion from a physiological point of view.Canad. M. A.J. 23:268, 1930.Google Scholar
  10. 10.
    Barkin, B. P. Secretory Mechanisms of the Digestive Glands (ed. 2). Hoeber, New York, 1950.Google Scholar

Copyright information

© Hoeber Medical Division • Harper & Row, Publishers 1965

Authors and Affiliations

  • D. W. Piper
    • 1
  • F. L. Broderick
    • 1
  • Barbara H. Fenton
    • 1
  • Deborah Beeston
    • 1
  1. 1.From the Department of MedicineUniversity of Sydney and Institute of Medical Research, Royal North Shore Hospital of SydneySydneyAustralia

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