Skip to main content
SpringerLink
Log in

Effect of histamine on the protein and mucus content of gastric juice

  • Published:
The American Journal of Digestive Diseases Aims and scope Submit manuscript

Summary

1. Histamine causes a fall in the concentration of both protein and mucus in gastric juice; the stimulatory effect of histamine on the volume of secretion, however, results in a marked rise in output of protein and a less marked rise in the output of mucus.

2. The effect of histamine is more marked on protein secretion than on mucus secretion, and the rise in output of protein cannot be explained by the effect on mucus secretion.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Riddell, M. T., Strong, J. A., andCameron, D. The electrolyte concentration of human gastric secretion.Quart. J. Exp. Physiol. 45:1, 1960.

    Google Scholar 

  2. Milton, G. W., Skyring, A. P., andGeorge, E. P. Histamine secretory tests in cats: an evaluation of results based upon Hollander's two-component theory.Gastroenterology 44:642, 1963.

    Google Scholar 

  3. Piper, D. W. The effect of histamine on pepsin secretion.Am. J. Dig. Dis. 5:880, 1960.

    Article  PubMed  Google Scholar 

  4. Kay, A. W. Effect of large doses of histamine on gastric secretion of HCl.Brit. Med. J. 2:77, 1953.

    PubMed  Google Scholar 

  5. Gornall, A. G., Bardawill, C. J., andDavid, M. M. Determination of serum proteins by means of biuret reaction.J. Biol. Chem. 277:751, 1949.

    Google Scholar 

  6. Richmond, V., Caputto, R., andWolf, S. Fractionation of the non dialyzable soluble compounds of gastric content by chromatography on Amberlite IRC-56.Arch. Biochem. 66:155, 1957.

    Article  PubMed  Google Scholar 

  7. Warren, L. The thiobarbituric acid assay of sialic acid.J. Biol. Chem. 234:197, 1959.

    Google Scholar 

  8. Dische, Z., andShettles, L. B. A specific color reaction of methyl pentoses and a spectrophotometric micro-method for their determination.J. Biol. Chem. 175: 595, 1948.

    Google Scholar 

  9. Babkin, B. P. The value of histamine as a test of gastric secretion from a physiological point of view.Canad. M. A.J. 23:268, 1930.

    Google Scholar 

  10. Barkin, B. P. Secretory Mechanisms of the Digestive Glands (ed. 2). Hoeber, New York, 1950.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. From the Department of Medicine, University of Sydney and Institute of Medical Research, Royal North Shore Hospital of Sydney, Sydney, Australia

    D. W. Piper M.R.C.P., F. L. Broderick M.B., Barbara H. Fenton B.Sc & Deborah Beeston

Authors
  1. D. W. Piper M.R.C.P.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. F. L. Broderick M.B.
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Barbara H. Fenton B.Sc
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Deborah Beeston
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

This work was supported by the New South Wales State Cancer Council, the Consolidated Research Fund of the University of Sydney and the Damon Runyon Memorial Fund Grant No. DRG-761. The helpful advice of Professor C. R. B. Blackburn is gratefully acknowledged.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Piper, D.W., Broderick, F.L., Fenton, B.H. et al. Effect of histamine on the protein and mucus content of gastric juice. Digest Dis Sci 10, 122–127 (1965). https://doi.org/10.1007/BF02236661

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02236661

Keywords

Search

Navigation