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Abnormalities of the small intestinal mucosa in Crohn's Disease (regional enteritis)

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Summary

Villous atrophy has been demonstrated in peroral biopsies and in resected intestine from patients with “Crohn's disease.” Though there is a widespread change it has been found to be patchy and less severe than that seen in idiopathic steatorrhoea. It has been pointed out that peroral biopsy may be of diagnostic importance in steatorrhoea patients in whom the differential diagnosis, on clinical grounds, is not clear-cut.

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Authors and Affiliations

  1. From the Departments of Gastroenterology and Histopathology, Central Middlesex Hospital, London, N.W.10, England

    Margot Shiner (M.R.C.S., L.R.C.P., D.C.H) & R. A. B. Drury D.M.

Authors
  1. Margot Shiner
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  2. R. A. B. Drury D.M.
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Additional information

Grateful acknowledgment is made to all the physicians and surgeons who treated the patients described in this paper, and to Mr. J. E. Mayhew for the histological preparations and Mr. W. Brackenbury for the photomicrographs used in the study.

Recipient of a grant from the Medical Research Council, London.

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Shiner, M., Drury, R.A.B. Abnormalities of the small intestinal mucosa in Crohn's Disease (regional enteritis). Digest Dis Sci 7, 744–759 (1962). https://doi.org/10.1007/BF02236112

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