Abstract
Colitis in neonatal pigs developed afterEscherichia coli organisms were present in the circulatory system for a minimum of 60 hours. The morphologic sequence of response was: macrophages in the lamina propria, swollen terminal capillary endothelium, adherence of fibrin and platelets to the endothelial cell membranes, extravascular fibrin, platelets, and erythrocytes, edema of the lamina propria and submucosa concurrent with lymphangiectasis and perilymphangitis.
This study did not identify the factors responsible for colitis but provided information thatE coli was a causitive agent in the neonatal monocontaminated pig.
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Supported in part by US Public Health Service Research Grant AI-06461 from the National Institute of Allergy and Infectious Diseases, and General Medical Research Grant FR-05567.
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Staley, T.E., Corley, L.D. & Jones, E.W. Early pathogenesis of colitis in neonatal pigs monocontaminated withEscherichia coli . Digest Dis Sci 15, 937–952 (1970). https://doi.org/10.1007/BF02236062
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DOI: https://doi.org/10.1007/BF02236062