Advertisement

The American Journal of Digestive Diseases

, Volume 10, Issue 11, pp 945–957 | Cite as

Hypogammaglobulinemia and steatorrhea

  • C. F. McCarthy
  • W. I. Austad
  • A. E. A. Read
Article

Summary

1. A patient with acquired idiopathic hypogammaglobulinemia and steatorrhea is described. Jejunal and ileal biopsies were histologically normal.

2. Special studies to elucidate the mechanism of the steatorrhea were carried out and tend to support the presence of an altered bacterial flora of the small intestine.

Keywords

Public Health Small Intestine Ileal Special Study Bacterial Flora 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Gitlin, D., Cross, P. A. M., andJaneway, C. A. The gammaglobulins and their clinical significance. II. Hypogammaglobulinaemia.New England J. Med. 260: 72, 1959.Google Scholar
  2. 2.
    Keewick, R. A., Vallet. L., Cutrush, M., Mollison, P. L., Thomas, A. R., Ghj, P. G. H., andSoothill, J. F. Estimation of gammaglobulin in the serum of patients with hypogammaglobulinaemia.J. Clin. Path. 14:470, 1961.Google Scholar
  3. 3.
    Firkin, B. G., andBlackburn, C. R. B. Congenital and acquired agammaglobulinaemia: report of four cases.Quart. J. Med. 27:176, 1958.Google Scholar
  4. 4.
    Sandford, J. P., Favour, C. B., andTribeman, M. S. Absence of serum gamma globulins in adult.New England J. Med. 250:1027, 1954.Google Scholar
  5. 5.
    Zinneman, H. H., Hall, W. H., andHeleer, B. I. Acquired agammaglobulinaemia: report of three cases.J.A.M.A. 156:1027, 1954.Google Scholar
  6. 6.
    Rosecan, M., Trubauch, F. E., Jr., andDanford, W. H. Agaminaglobulinaemia in adults.Am. J. Med. 19:303, 1955.Google Scholar
  7. 7.
    Citron, K. M. Agammaglobulinaemia with splenomegaly.Brit. M. J. 1:1148, 1957.Google Scholar
  8. 8.
    Israel-Assilain, R., Chebat, J., Burtin, P., andTeil, P. Un cas d'agammaglobulinaemia avcc bronchiectasis et eczema allergique.Soc. med. hop. Paris 76:513, 1960.Google Scholar
  9. 9.
    Good, R. A. Studies on agammaglobulinaemia. II. Failure of plasma cell formation in bone marrow and lymph nodes of patients with agammaglobulinaemia.J. Lab. Clin. & Med. 46:167, 1955.Google Scholar
  10. 10.
    Collins, H. D., andDudley, H. R. Agammaglobulinaemia and bronchiectasis: report of two cases in adults with autopsy findings.New England J. Med. 252:255, 1955.Google Scholar
  11. 11.
    Brukel, R. W., Neuefer, P., andFranken, F. H. Globulin-mangelsyndrome und humorale abwehr unter besonderer Berucksichtigung der A. Y. Globulinaemie.Klin. Wchnschr. 34:304, 1956.Google Scholar
  12. 12.
    Brehn, T. H., andMorton, M. E. Defective serum gammaglobulin formation.Ann. Int. Med., 43:465. 1955.Google Scholar
  13. 13.
    Barandum, S., Buckner, H., andHassig, A. Das Antikorpermangelsyndrom: Agammaglobulinaemie.Schweiz. med. Wehnschr. 86: 33, 1956.Google Scholar
  14. 14.
    Arends, T., Conrad, E. V., andRundles, R. W. Serum proteins in Hodgkin's disease and maliguant lymphoma.Am. J. Med. 16:833, 1954.Google Scholar
  15. 15.
    Painter, T. S., andKorst, D. R. Studies on acquired hypogammaglobulinaemia: evidence of antibody formation and report of a case with bronchial asthma.New England J. Med. 260:15, 1959.Google Scholar
  16. 16.
    Lang, N., Schettler, G., andWildhack, R. Über einem Fall von Agammaglobulinämia und das Verhallen parenteral zugefuhrtea radioaktiv markierten Gamma-globulinsuiserum.Klin. Wchnschr. 32: 856, 1954.Google Scholar
  17. 17.
    Prasad, A. S., Reiner, E., andWatson, C. J. Syndrome of hypogammaglobulinaemia, splenomegaly and hypersplenism.Blood 12:926, 1957.Google Scholar
  18. 18.
    Zelman, S., andLewin, H. Adult agammaglobulinaemia associated with multiple congenital anomalies.Am. J. Med. 25:150, 1958.Google Scholar
  19. 19.
    Wolf, J. K. Primary acquired agammaglobulinaemia with a family history of collagen disease and haematological disorders.New England J. Med. 266:473, 1962.Google Scholar
  20. 20.
    Barrett, B., andVolwiler, W. Agammaglobulinaemia and hypogammaglobulinaemia: first five years.J.A.M.A. 164:886, 1957.Google Scholar
  21. 21.
    Craig, J. M., Giulin, D., andJeweut, T. C. Responses of lymph nodes of normal and congenitally agammaglobulinic children to antigenic stimulation.Am. J. Dis. Child. 88:626, 1955.Google Scholar
  22. 22.
    Janeway, C. A., andGulex, D. Gammaglobulins.Adv. Pediat. 9:65, 1955.Google Scholar
  23. 23.
    Cohen, J., Cohen, A. L., andCohen, D. Agammaglobulinaemia con esteatorrhoea y probable tuberculosis.Prensa méd, argent, 48:2203, 1961.Google Scholar
  24. 24.
    Cohen, N., Paley, D., andJanowitz, H. D. Acquired hypogammaglobulinaemia and sprate: report of a case and review of the literature.J. Mt. Sinai Hasp. 28:421, 1961.Google Scholar
  25. 25.
    Pelkonen, R., Siurala, M., andVuowo, P. Inherited agammaglobulinaemia with malabsorption and marked alterations in gastrointestinal mucosa.Acta med. scandinav. 173:549, 1963.Google Scholar
  26. 26.
    Green, I., andSperber, R. J. Hypogammaglobulinaemia, arthritis, sprue and megaloblastic anaemia.New York J. Med. 10:754, 1962.Google Scholar
  27. 27.
    Huizenga, K. A., Wollaeger, E. E., Green, P., andMcKenzie, B. F. Serum globulin deficiencies in nontropical sprue, with a report of two cases of acquired agammaglobulinaemia.Am. J. Med. 31:572, 1961.Google Scholar
  28. 28.
    Kabler, J. D. Rare malabsorption syndromes.Ann. Int. Med. 52:1221, 1960.Google Scholar
  29. 29.
    Zinneman, H. H., andHall, W. H. Steatorrhoea and probable tuberculosis with acquired hypogammaglobulinaemia.Am. Rev. Tuberc. 74: 713, 1956.Google Scholar
  30. 30.
    Cooke, W. R., Winer, W., andShinton, N. K. Agammaglobulinaemia. Report of two adult cases.Brit. M. J. 1:1151, 1957.Google Scholar
  31. 31.
    Malvezin, M. J., Conte, M., Lagenie, B., andJavlin, P. Sprue chez un agammaglobutemique.Arch. mal. app. digest. 48: 504, 1959.Google Scholar
  32. 32.
    Hollingworth, G. T. Congenital hypogammaglobulinaemia and megaloblastic anaemia presenting as a case of bronchiectasis.Proc. Roy. Soc. Med. 55: 606, 1962.Google Scholar
  33. 33.
    Swift, P. N. Hypogammaglobulinaemia, steatorrhoea and megaloblastic anaemia.Postgrad. M. J. 38:633, 1962.Google Scholar
  34. 34.
    Waldman, T. A., andLaster, L. Abnormalities of albumin metabolism in patients with hypogammaglobulinaemia.J. Clin. Invest. 43: 473, 1962.Google Scholar
  35. 35.
    Jeejerhoy, K. N., andCoghill, N. F. The measurement of gastro-intestinal protein loss by a new method.Gut, 2:123. 1961.Google Scholar
  36. 36.
    Jeejebhoy, K. N. Hypoanabolic hypoalbuminaemia in gastro-intestinal disease.Brit. M. J. 1:30, 1964.Google Scholar
  37. 37.
    Badenoch, J., Bedford, P. D., andEvans, J. R. Massive diverticulosis of the small intestine with steatorrhoea and megaloblastic anaemia.Quart. J. Med. 24:321, 1955.Google Scholar
  38. 38.
    Mollin, D. L., Booth, C. C. andBaker, S. J. The absorption of vitamin B12 in control subjects in Addisonian pernicious anaemia and in the malabsorption syndrome.Brit. J. Haemat. 3:412, 1957.Google Scholar
  39. 39.
    Veall, N., andVetter, H. Radio-isotope Techniques in Clinical Research and Diagnosis. Rutterworth, 1958. p. 274.Google Scholar
  40. 40.
    Adams, J. F., andCartwrigm, E. J. The reliability and reproducibility of the Schilling test in primary malabsorptive disease and after partial gastrectomy.Gut 4:32, 1963.Google Scholar
  41. 41.
    Weissbach, H., King, W., Sjoerdsma, A., andUdenfriend, S. Formation of indole-3-acctic acid and tryptamine in animals.J. Biol. Cliem. 234:81, 1959.Google Scholar
  42. 42.
    Haverback, B. J., Dyce, B., andThomas, H. V. Indole metabolism in the malabsorption syndrome.New England J. Med. 262:15, 754, 1960.Google Scholar

Copyright information

© Hoeber Medical Division • Harper & Row, Publishers, Incorporated 1965

Authors and Affiliations

  • C. F. McCarthy
    • 1
  • W. I. Austad
    • 1
  • A. E. A. Read
    • 1
  1. 1.From the Department of MedicineThe University of Bristol at Bristol Royal InfirmaryBristolEngland

Personalised recommendations