Effect of antrectomy on gastric secretion following duodenal exclusion
The effect of antrectomy on acid secretion was studied in Pavlov-pouch dogs from which the duodenal inhibitory mechanism was excluded prior to antrectomy. The secretion was stimulated with graded doses of histamine, gastrin, and a combination of graded doses of histamine and gastrin plus a fixed dose of Urecholine.
Following exclusion of the duodenum from the normal gastrointestinal continuity, the maximal acid response of the Pavlov-pouch dogs was significantly increased. Subsequent antrectomy produced a highly significant decrease in the acid response to histamine, while the acid output of dogs stimulated with graded doses of gastrin was reduced only slightly following antrectomy. Resection of the duodenal bulb produced a small decrease in the acid output of the Pavlov pouches in response to graded doses of histamine and a highly significant decrease in acid response to graded doses of gastrin.
These findings demonstrate the importance of the duodenal inhibitory mechanism in regulating the gastric acid secretory response, and the potentiating effect of spontaneously released gastrin from the antrum to injected histamine. Our results lend support to the theory that endogenous gastrin is located in the duodenal bulb, and that these minute amounts of gastrin are significant in the production of acid secretion.
KeywordsHistamine Gastric Acid Acid Secretion Small Decrease Gastric Secretion
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