Evaluation of the antisecretory effect of a new anticholinergic agent—heteronium bromide
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Gastric secretory studies to determine the effectiveness of heteronium bromide as an anticholinergic agent were undertaken using 7 elderly patients with peptic ulcer who were shown to have elevated basal and post-Histalog gastric secretion.
The effectiveness of this agent in reducing gastric volume and suppressing free and total acid secretion was compared to basal conditions (a blank) and to a generally accepted anticholinergic agent, propantheline bromide.
The results were subjected to statistical evaluation by both the analysis of variance and Duncan's Multiple Range Test. Heteronium bromide, in dosages of 1.6 and 3.2 mg when compared to a basal determination was shown to decrease significantly the volume of gastric secretion and the quantity of free and total acid as measured in milliequivalents. When 15 mg of propantheline bromide was given, a comparable effect was not obtained. However, after Histalog stimulation both heteronium bromide and propantheline bromide had a significant and comparable effect.
No adverse effects were seen. These observations indicate that heteronium bromide is a safe and effective anticholinergic agent.
KeywordsPublic Health Adverse Effect Bromide Elderly Patient Peptic Ulcer
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