The American Journal of Digestive Diseases

, Volume 14, Issue 5, pp 305–314 | Cite as

Evaluation of the antisecretory effect of a new anticholinergic agent—heteronium bromide

  • Sander Goodman
  • F. E. Smyrniotis
  • Akira Funahashi


Gastric secretory studies to determine the effectiveness of heteronium bromide as an anticholinergic agent were undertaken using 7 elderly patients with peptic ulcer who were shown to have elevated basal and post-Histalog gastric secretion.

The effectiveness of this agent in reducing gastric volume and suppressing free and total acid secretion was compared to basal conditions (a blank) and to a generally accepted anticholinergic agent, propantheline bromide.

The results were subjected to statistical evaluation by both the analysis of variance and Duncan's Multiple Range Test. Heteronium bromide, in dosages of 1.6 and 3.2 mg when compared to a basal determination was shown to decrease significantly the volume of gastric secretion and the quantity of free and total acid as measured in milliequivalents. When 15 mg of propantheline bromide was given, a comparable effect was not obtained. However, after Histalog stimulation both heteronium bromide and propantheline bromide had a significant and comparable effect.

No adverse effects were seen. These observations indicate that heteronium bromide is a safe and effective anticholinergic agent.


Public Health Adverse Effect Bromide Elderly Patient Peptic Ulcer 
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  1. 1.
    Chernish, S. M., andRosenak, B. D. The effect of a new anticholinergic drug, heteronium bromide, on basal gastric secretion.Amer J Dig Dis 10:697, 1965.Google Scholar
  2. 2.
    Goodman, L. S., andGilman, A. “Propantheline.” InThe Pharmacological Basis of Therapeutics (ed. 3) Macmillan, New York, p. 536.Google Scholar
  3. 3.
    Hill, A. B. Principles of Medical Statistics (ed. 8) Oxford, New York, 1966.Google Scholar
  4. 4.
    Duncan, D. D. Multiple range and multiple S tests.Biometrics 11:1, 1955.Google Scholar
  5. 5.
    Grossman, M. I. Gastric secretion of free acid (to pH 3.5) in mEq/hr.Gastroenterology 45:14, 1963.Google Scholar
  6. 6.
    Janowitz, H. D., Grossman, M. I., Hightower, N. C., andMoore, E. W. A Scientific Exhibit. American Gastroenterological Association, Annual Meeting, Chicago, Ill., May 27, 1966.Google Scholar
  7. 7.
    Emas, S., andGrossman, M. I. Comparison of gastric secretion in conscious dogs and cats.Gastroenterology 52:29, 1967.Google Scholar

Copyright information

© Hoeber Medical Division • Harper & Row, Publishers, Incorporated 1969

Authors and Affiliations

  • Sander Goodman
    • 1
  • F. E. Smyrniotis
    • 1
  • Akira Funahashi
    • 1
  1. 1.From the Department of Internal Medicine of the University of Cincinnati College of Medicine, and the Daniel Drake Memorial HospitalCincinnati

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