Diseases of the Colon & Rectum

, Volume 43, Issue 5, pp 692–700 | Cite as

Long-term clinical course and prognostic factors in intestinal Behçet's Disease

  • Il Ju Choi
  • Joo Sung Kim
  • Sung Duk Cha
  • Hyun Chae Jung
  • Jae-Gahb Park
  • Sung Song
  • Chung Young Kim
Original Contributions
  • 93 Downloads

Abstract

PURPOSE: The present study was aimed at evaluating the long-term course of intestinal Behçet's disease and determining predictive factors of prognosis. METHODS: This report is a retrospective study based on the records of 43 patients with intestinal Behçet's disease. The mean follow-up duration was 73±60 months. We evaluated the efficacy of medical treatment for the intestinal lesion at initial eight weeks. The cumulative probabilities were calculated by using Kaplan-Meier method, and the results were compared by using the log-rank test. RESULTS: Sixteen patients (38 percent) achieved a complete remission of intestinal lesions eight weeks after medical treatment had begun. The patients who achieved a complete remission had a lower probability of receiving an operation than those who had not (13 percent at 2 and 5 yearsvs. 36 and 43 percent, respectively;P=0.028). The recurrence probability of intestinal lesions was 25 percent at two years and 49 percent at five years after complete remission with medical treatment. Patients who had a history of intestinal perforation or fistula had a higher probability of recurrence after operation than those without such history (59vs. 33 percent at 2 years; 88vs. 57 percent at 5 years;P=0.020). Patients who had taken azathioprine had a lower probability of receiving reoperation than those who did not (7vs. 25 percent at 2 years; 25vs. 47 percent at 5 years;P=0.035). The length of ileal resection and whether hemicolectomy was performed had no significant effect on the recurrence or reoperation rate. CONCLUSIONS: Intestinal Behçet's disease frequently requires a surgical treatment and has a high recurrence rate. The patients who achieved a complete remission with medical treatment, who had no history of intestinal performation, and who received azathioprine after operation showed better clinical courses. Resection of a short segment of bowel would be a more appropriate surgical procedure.

Key words

Behçet's Disease Intestinal disease Reoperation Recurrence Azathioprine Intestinal perforation Hemicolectomy 

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Copyright information

© American Society of Colon and Rectal Surgeons 2000

Authors and Affiliations

  • Il Ju Choi
    • 3
  • Joo Sung Kim
    • 3
  • Sung Duk Cha
    • 3
  • Hyun Chae Jung
    • 3
    • 2
  • Jae-Gahb Park
    • 1
  • Sung Song
    • 3
  • Chung Young Kim
    • 3
  1. 1.Department of SurgerySeoul National University College of MedicineSeoulKorea
  2. 2.Institute for Endemic Diseases, Medical Research CenterSeoul National University College of MedicineSeoulKorea
  3. 3.Department of Internal MedicineSeoul National University College of MedicineSeoulKorea

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