Reduction of portal hypertension by ganglionic blockade
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The effect of the ganglionic blocking agent, trimethaphan camsylate, on the portal venous and systemic arterial blood pressure was evaluated in 58 cirrhotic patients who had esophageal varices secondary to portal hypertension. Portal venous pressure was monitored by splenic-pulp manometry. Trimethaphan induced a mean decrease of 31.0% in portal pressure and 39.3% in arterial pressure. Both decrements were highly significant (P<0.005). Pressure decrements generally were greater in those patients whose initial pressure readings were higher. Reduced levels of portal and arterial blood pressure were maintained throughout the period of drug infusion.
KeywordsArterial Pressure Arterial Blood Pressure Portal Hypertension Venous Pressure Cirrhotic Patient
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