Abstract
The effect of hypophysectomy on glucose and galactose absorption from the small bowel was studied in young rats. In vitro studies were performed on intestinal rings, and in vivo studies were done on jejunal loops. Glucose and galactose absorption was found to be increased in hypophysectomized rats, both in vitro and in vivo, 5 days after hypophysectomy, but these levels returned to the control range 11 days after surgery. Conversion of glucose-1-14C to14CO2, by small bowel rings obtained from hypophysectomized rats 5 days after surgery, was found to be enhanced. These observations suggest that, soon after hypophysectomy, glucose is metabolized at a higher rate by the intestine.
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Supported by US Public Health Service Grant 13387 from the National Institute of Arthritis and Metabolic Diseases, and Veterans Administration Medical Research Funds.
The authors wish to thank Dr. Maurice S. Raben, Department of Medicine, New England Medical Center Hospitals, Boston, Mass, and Professor Gerhard Schmidt, Department of Biochemistry, Tufts University School of Medicine, Boston, Mass for their help and advice in the course of these studies; and Mr. Albert H. Gamache for his technical assistance.
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Havivi, E., Levitan, R. Absorption of glucose and galactose from the small intestine of hypophysectomized rats. Digest Dis Sci 16, 299–305 (1971). https://doi.org/10.1007/BF02235204
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DOI: https://doi.org/10.1007/BF02235204