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Pepsin output from the damaged canine Heidenhain pouch

The American Journal of Digestive Diseases volume 16, pages 403–407 (1971)Cite this article

Abstract

In numerous experiments, it has been shown that back diffusion of hydrogen ion across the abnormally permeable gastric mucosa causes damage. This type of situation may exist in patients with gastric ulcers, and these experiments have been considered as models for studying the etiology of gastric ulcer disease. Using dogs with Heidenhain pouches and gastric fistulas, the current experiments demonstrate that when the gastric mucosa is damaged by high concentrations of hydrochloric acid, pepsin output increases. Pepsin output was directly related to the back diffusion of hydrogen, suggesting that pepsin output may be increased in the abnormally permeable mucosa and may be of etiologic importance in ulcer disease.

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Author information

Affiliations

  1. From the Department of Physiology and Biophysics, University of Oklahoma Medical Center, Oklahoma City, Okla

    Leonard R. Johnson PhD

Authors
  1. Leonard R. Johnson PhD
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Additional information

Supported by Public Health Service Research Grants AM 8354 and AM 14392.

The authors wish to thank Mr. John L. Washington and Mrs. Louise H. Wyss for providing expert technical assistance for this study; especially Dr. Morton I. Grossman for part of the support for this study; and Dr. Horace W. Davenport for ideas and valuable advice.

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Johnson, L.R. Pepsin output from the damaged canine Heidenhain pouch. Digest Dis Sci 16, 403–407 (1971). https://doi.org/10.1007/BF02235084

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  • DOI: https://doi.org/10.1007/BF02235084

Keywords

  • Public Health
  • Hydrogen
  • Hydrochloric Acid
  • Numerous Experiment
  • Gastric Mucosa