Chemistry of Natural Compounds

, Volume 35, Issue 2, pp 179–181 | Cite as

Reaction of 3β-chloro-5α,6α-epoxysteroids with trifluoroacetic acid

  • N. V. Kovganko
  • S. K. Ananich


It has been established that on the interaction of the 5α,6α-epoxysteroids (1a−c) with trifluoroacetic acid in chloroform the 6-trifluoroacetates of the 5α,6β-diols (2a−c) are formed in high yield. The alkaline hydrolysis of the trifluoroacetates (2a−c) leads to the corresponding diols (3a−c).


Organic Chemistry Chloroform Diol Trifluoroacetic Acid Alkaline Hydrolysis 
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Copyright information

© Kluwer Academic/Plenum Publishers 1999

Authors and Affiliations

  • N. V. Kovganko
  • S. K. Ananich

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