Reaction of 3β-chloro-5α,6α-epoxysteroids with trifluoroacetic acid
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It has been established that on the interaction of the 5α,6α-epoxysteroids (1a−c) with trifluoroacetic acid in chloroform the 6-trifluoroacetates of the 5α,6β-diols (2a−c) are formed in high yield. The alkaline hydrolysis of the trifluoroacetates (2a−c) leads to the corresponding diols (3a−c).
KeywordsOrganic Chemistry Chloroform Diol Trifluoroacetic Acid Alkaline Hydrolysis
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