Diseases of the Colon & Rectum

, Volume 44, Issue 9, pp 1268–1273 | Cite as

Extended follow-up of patients treated with cytotoxic chemotherapy for intra-abdominal desmoid tumors

  • Lisa S. Poritz
  • Martin Blackstein
  • Terri Berk
  • Steve Gallinger
  • Robin S. McLeod
  • Zane Cohen
Original Contributions
  • 33 Downloads

Abstract

BACKGROUND: Cytotoxic chemotherapy can achieve a good initial response in inoperable desmoid tumors that have caused progressive obstruction of the gastrointestinal and urinary tracts and have caused unrelenting pain. METHODS: We have reviewed 8 patients (3 male) with desmoid tumors and familial adenomatous polyposis who underwent cytotoxic chemotherapy for inoperable gastrointestinal obstruction and/or uncontrolled pain. They were treated with doxorubicin and dacarbazine followed by carboplatin and dacarbazine. RESULTS: Follow-up after cytotoxic chemotherapy in the 7 patients for whom it was available was a mean of 42 (range 24–54) months. Two patients achieved complete remission after therapy. Four patients achieved a partial remission after completing all or some of the chemotherapy regimen; of these, three remained in stable remission, whereas the other was lost to follow-up. There were two recurrences that required further therapy; one of these patients was treated with further chemotherapy, which induced a second remission, and the other was treated with pelvic exenteration and has subsequently died. CONCLUSIONS: Most patients had a substantial response to cytotoxic chemotherapy; however, two patients required additional therapy 24 and 30 months after cytotoxic chemotherapy, respectively. Cytotoxic chemotherapy is effective in producing short-term and long-term remission in these difficult patients.

Key words

Desmoid tumors Familial adenomatous polyposis Cytotoxic chemotherapy 

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Copyright information

© The American Society of Colon and Rectal Surgeons 2001

Authors and Affiliations

  • Lisa S. Poritz
    • 1
  • Martin Blackstein
    • 1
  • Terri Berk
    • 1
  • Steve Gallinger
    • 1
  • Robin S. McLeod
    • 1
  • Zane Cohen
    • 1
  1. 1.From the Steve Atanas Starvo Familial Gastrointestinal Cancer Registry, Mount Sinai Hospital and theUniversity of TorontoTorontoCanada

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