Abstract
PURPOSE: The aim of this study was to remove completely the risk of malignant transformation without permanent or temporary fecal diversion in a patient with extensive anal intraepithelial neoplasia. METHODS: All anal canal mucosa and the lowest 1.5 cm of rectal mucosa were excised and the adjacent rectal mucosa and submucosa advanced to the anal verge skin. RESULTS: The patient achieved normal continence within a month after the operation. Multiple anal canal biopsies at 12 months after the operation revealed normal rectal mucosa. CONCLUSIONS: Total anal mucosal excision offers a relatively simple means of removing the malignant risk of anal intraepithelial neoplasia without fecal diversion in selected patients.
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Lyons, M., Francis, N. & Allen-Mersh, T.G. Treatment of grade 3 anal intraepithelial neoplasia by complete anal mucosal excision without fecal diversion. Dis Colon Rectum 42, 1342–1344 (1999). https://doi.org/10.1007/BF02234227
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DOI: https://doi.org/10.1007/BF02234227