The American Journal of Digestive Diseases

, Volume 11, Issue 3, pp 217–230 | Cite as

Reversal of insulin inhibition of gastric secretion by intravenous injection of potassium

  • Basil I. Hirschowitz
  • George Sachs


Insulin inhibition of gastric electrolyte secretion during a histamine infusion in 8 dogs was completely and rapidly reversed by an intravenous injection of KCl and the reversal maintained for 1–1 1/2 hr. after the injection. The continuous infusion of KCl after insulin prevented any change in the concentrations of H+, Cl, and Na+, but there was partial inhibition of K+ and volume secretion. The results suggested that the mechanism of insulin inhibition might be a redistribution of intracellular K+ with depletion of K+ from sites essential to secretion, and replenishment by injected K+ with resulting restoration of secretion.


Public Health Potassium Histamine Intravenous Injection Continuous Infusion 
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Copyright information

© Hoeber Medical Division • Harper & Row, Publishers, Incorporated 1966

Authors and Affiliations

  • Basil I. Hirschowitz
    • 1
  • George Sachs
    • 1
  1. 1.From the Division of Gastroenterology, Department of MedicineUniversity of Alabama Medical CenterBirmingham

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