The American Journal of Digestive Diseases

, Volume 10, Issue 9, pp 814–825 | Cite as

Development of urea-cycle enzymes in the juvenile rat: Effect of long-term administration of L-monosodium glutamate and ammonium acetate

  • Jack H. Hutchinson
  • Daniel H. Labby
Article

Summary and conclusions

Liver urea-cycle enzyme specific activities increase with age and body weight of the developing juvenile rat, with the exception of arginine synthetase. The failure of rat liver arginine synthetase to respond in a similar fashion during the observed growth period is unexplained. Liver carbamyl phosphate synthetase specific activity was markedly and significantly increased during the early oral administration of both Lmonosodium glutamate and ammonium acetate. Prolonged administration of these substances resulted in a return toward control values, indicating adaptation of carbamyl phosphate synthetase to the administered substrates. Liver arginase specific activity was decreased afer 5 weeks of ammonium acetate administration. Liver ornithine transcarbamylase, arginine synthetase, and arginase specific activities did not significantly differ from those of controls during 6 weeks of intragastric L-monosodium glutamate administration.

The induction of rat liver carbamyl phosphate synthetase during L-monosodium glutamate administration suggests a hypothesis for ammonia detoxification not previously considered in the literature. The response of rat liver carbamyl phosphate synthetase is related to current concepts of ammonia intoxication which may occur in human patients with far advanced liver disease.

Keywords

Ammonium Acetate Arginase Advance Liver Disease Carbamyl Ornithine Transcarbamylase 

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Copyright information

© Hoeber Medical Division Harper • Harper & Row, Publishers 1965

Authors and Affiliations

  • Jack H. Hutchinson
    • 1
  • Daniel H. Labby
    • 1
  1. 1.From the Metabolic Research Laboratory, and the Department of Medicine, Division of Diabetes and MetabolismUniversity of Oregon Medical SchoolPortland

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