The American Journal of Digestive Diseases

, Volume 10, Issue 3, pp 228–238 | Cite as

Responses of the hepatic circulation to various pharmacologic agents: A Review

  • A. Douglas Bender
  • Steven M. Horvath
Article

Summary and conclusions

The response of the hepatic circulation to various drugs is related to a number of diffierent hemodynamic factors: those which are the direct results of the drug acting on the vessels of the liver, and indirect influences as well resulting from hemodynamic changes induced in other components of the peripheral circuit. The effect on hepatic flow per se is the algebraic sum of these factors, the predominance being related directly to the action of the drug. With some (vasopressin, trimethaphan), a parallel effect on each regional circuit is produced, in which case, no selective or preferential redistribution of flow is evident. In other instances, however, the hepatic circulation may be favored (norepinephrine, phenylephrine, guanethidine) or deficient (angiotensin, serotonin) with respect to changes in total peripheral flow, depending on the extrahepatic influences of the drug. Indeed, changes in hepatic flow may reflect strictly an extrahepatic effect (isoproterenol).

It may be concluded that the response of the hepatic circulation to drugs is the result of a combination of factors, and in the intact animal, rarely reflects the response of the hepatic vasculature alone.

Keywords

Angiotensin Vasopressin Isoproterenol Phenylephrine Hemodynamic Change 

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Copyright information

© Hoeber Medical Division • Harper & Row, Publishers 1965

Authors and Affiliations

  • A. Douglas Bender
    • 1
    • 2
  • Steven M. Horvath
    • 1
    • 2
  1. 1.From the Research and Development DivisionSmith Kline and French LaboratoriesPhiladelphia
  2. 2.the Environmental Stress LaboratoryUniversity of CaliforniaSanta Barbara

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