Pressure studies in the normal human jejunum
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Intraluminal pressure changes of the human upper jejunum immediately distal to the ligament of Treitz were recorded in 22 healthy volunteers. Simultaneous recordings were obtained through 3 open-tip catheters, where orifices were 10 cm. apart. The effect of distal obstruction with an inflatable balloon was also studied. Tracings were analyzed quantitatively as well as for the appearance of their general pattern. Of the 3 methods of assessing motility quantitatively (numerical wave count, percent time activity, and planimetry), planimetry gave the most reliable results.
Obstruction by a balloon did not significantly increase bowel function, at least for the first 15 min., but the release of the obstruction was followed by significant decrease in activity.
Different waves and patterns were seen during this study. These were simple monophasic pressure waves or waves representing prolonged base line elevation. These waves were either single or repetitive, and were frequently indicative of correlated distal progression. Distal obstruction or release of the balloon did not influence the occurrence of caudal sequences of long outbursts of rhythmic activity, but greatly diminished the frequency of caudal sequences of simple monophasic waves.
KeywordsCatheter Pressure Wave Base Line Bowel Function Rhythmic Activity
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- 1.Pfungen, V. Versuche über die Bewegungen des Antrum pyloricum beim Menschen.Centralblatt fur Physiol. 1:220, 1887.Google Scholar
- 2.Grage, W. J., Wolf, S., andWolff, H. G. The Human Colon: An Experimental Study based on Direct Observation of Four Fistulous Subjects. Hoeber, New York, 1951.Google Scholar
- 3.Ghormley, R. K., Hightower, N. C, Jr., Code, C. F., andPriestley, J. T. Observations on intestinal motility through a paper-thin abdominal wail 14 years after removal of epithelioma: Report of a case.Proc. Staff Meet. Mayo Clin. 29:211, 1954.Google Scholar
- 4.Barclay, A. E. Direct X-ray cinematography with a preliminary note on the nature of the non-propulsive movements of the large intestine.Brit. J. Radiol. 8: 652, 1935Google Scholar
- 5.Cannon, W. B. Auscultation of the rhythmic sounds produced by the stomach and intestines.Am. J. Physiol. 14:339, 1905.Google Scholar
- 7.Chapman, W. P., Rowlands, E. N., Taylor, A., andJones, C. M. Multiple-balloon-kymograph recording of variations in motility of the upper small intestine in man during long observation periods before and after placebo administration.Gastroenterology 15: 351, 1950.Google Scholar
- 8.Hightower, N. C., Jr. Comparison of intraluminal pressures and motility patterns in the gastrointestinal tract of human beings when recorded by balloon and direct (electrical transducer) pressure system.Fed. Proc. 11:69, 1952.Google Scholar
- 9.Hightower, N. G, Jr. The registration of gastrointestinal intraluminal pressures in man; the comparison of a balloon method and a direct pressure measuring method of recording. (Thesis, University of Minnesota Graduate School, 1952.)Google Scholar
- 10.Quigley, J. P., andBrody, D. A. Registration of digestive tract intralumen pressures.Meth. Med. Res. 4:109, 1951.Google Scholar
- 12.Ardenne, M. Von, Mielke, H., Rackwitz, H., andVollard, F. Die Technik des Verschluckbaren Intestinalsenders.Nachrichtentechnik 9:449, 1959.Google Scholar
- 13.Jacobson, B., andLindberg, B. F. M. receiving system for endoradiosonde techniques.IRE Trans. Med. Electron. M. E. 7:334, 1960.Google Scholar
- 15.Templeton, R. D., andLawson, H. Studies in motor activity of large intestine; normal motility in dog recorded by tandem balloon method.Am. J. Physiol. 96:667, 1931.Google Scholar
- 16.Ramorino, M. L., andColagrande, C. Intestinal motility; Preliminary studies with telemetering capsules and synchronized fluorocinematography.Am. J. Dig. Dis. 9:64, 1964.Google Scholar
- 18.Bass, P., andWiley, J. N. Electric and extraluminal contractile force activity from anastomosed duodenum of dog. From Parke, Daxis & Co. Research Laboratories, Ann Arbor, Mich. Personal communication, 1964.Google Scholar
- 19.Bass, P., andWiley, J. N. The effects of ligation and morphine on motor and electric activity of the duodenum of dog. From Parke, Davis & Co. Research Laboratories, Ann Arbor, Mich. Personal communication, 1964.Google Scholar
- 20.Ingelfinger, F. J., andAbbott, W. O. Intubation studies of the human small intestine. XX. The diagnostic significance of motor disturbances.Am. J. Dig. Dis. 7:468, 1940.Google Scholar
- 22.Chapman, W. P., Rowlands, E. N., andJones, C. M. Antispasmodic drugs: Evaluation of their effects on the motor activity of the upper portion of the small intestine in man.J.A.M.A. 143:627, 1950.Google Scholar