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Familial celiac disease with intestinal disaccharidase deficiencies

Summary

Familial celiac disease was demonstrated in at least 2 members of a studied family. Intestinal disaccharidase activity, evaluated in 4 members of the family by qualitative and quantitative assays of their intestinal mucosa, was found to be diminished. Disaccharidase activity improved after removal of gluten from the diet but lactase deficiency persisted. The histologic appearance of the intestinal mucosa improved with prolonged therapy; however, lactase deficiency persisted even after the mucosa had returned to normal. Possibly an underlying lactase deficiency precipitated gluten-sensitive enteropathy with mucosal damage and additional disaccharidase deficiencies.

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Supported in part by Grant HD 00406-02 from the National Institute of Child Health and Human Development, National Institutes of Health.

We are grateful to Dr. Douglas C. Heiner for performing antigen and antigen-precipitin studies.

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Lifshitz, F., Holman, G. Familial celiac disease with intestinal disaccharidase deficiencies. Digest Dis Sci 11, 377–388 (1966). https://doi.org/10.1007/BF02233632

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  • DOI: https://doi.org/10.1007/BF02233632

Keywords

  • Public Health
  • Celiac Disease
  • Intestinal Mucosa
  • Mucosal Damage
  • Histologic Appearance