The American Journal of Digestive Diseases

, Volume 11, Issue 6, pp 489–494 | Cite as

Gastrointestinal manifestations of amyloidosis

Review of the problem with report of a representative case
  • Robert S. Merrill
Case Reports

Summary

A case of primary systemic amyloidosis in which the diagnosis was made antemortem is presented. Unusual gastroenterologic features included epigastric pain as the presenting complaint, proved gastric and duodenal ulceration, an episode of acute pancreatitis, and terminal jaundice. The usual gastrointestinal features included diffuse gastrointestinal tract involvement, hepatomegaly, changes in serum protein, and essentially normal liver-function tests.

Keywords

Public Health Pancreatitis Gastrointestinal Tract Acute Pancreatitis Duodenal Ulceration 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Hass, G., andSchulz, R. Z. Amyloid. I. Method of isolating amyloid from other tissue elements.Arch, Path. 30:240, 1940.Google Scholar
  2. 2.
    Calkins, E., Cohen, A. S., andLarsen, B. Amyloidosis: Preliminary clinical, chemical and experimental observations.Ann. New York Acad. Sc. 86:1033, 1960.Google Scholar
  3. 3.
    Levine, R. A., Payne, M. A., andBurkholder, P. M. Asymptomatic primary systemic amyloidosis.Ann. Int. Med. 56:397, 1962.PubMedGoogle Scholar
  4. 4.
    Gueft, B., andGhioni, J. J. The site of formation and ultrastructure of amyloid.Am. J. Path. 43:837, 1963.PubMedGoogle Scholar
  5. 5.
    Dahlin, D. C. Amyloidosis.Proc. Staff Meet. Mayo Clin. 24:637, 1949.Google Scholar
  6. 6.
    Dahlin, D. C. Classification and general aspects of amyloidosis.M. Clin. North America 34:1107, 1950.Google Scholar
  7. 7.
    Koletsky, S., andStecher, R. M. Primary systemic amyloidosis.Arch. Path. 27:267, 1939.Google Scholar
  8. 8.
    Reimann, H., Sahyoun, P., andChaglassion, H. Primary amyloidosis.Arch. Int. Med. 93:673, 1954.Google Scholar
  9. 9.
    Reimann, H. A., Kovcky, R. F., andEcklund, C. M. Primary amyloidosis limited to tissues of mesodermal origin.Am. J. Path. 11:977, 1935.Google Scholar
  10. 10.
    Mathews, W. H. Primary systemic amyloidosis.Am. J. M. Sc. 228:317, 1954.PubMedGoogle Scholar
  11. 11.
    Briggs, G. W. Amyloidosis.Ann. Int. Med. 55:943, 1961.PubMedGoogle Scholar
  12. 12.
    Heitzman, E. J., Heitzman, G. C, andEiliott, C. F. Primary esophageal amyloidosis.Arch. Int. Med. 109:595, 1962.Google Scholar
  13. 13.
    Clinical Staff Conference at N. I. H. Primary amyloidosis.Ann. Int. Med. 52:668, 1960.Google Scholar
  14. 14.
    Rukavina, J. G. Primary systemic amyloidosis Medicine 55: 239, 1956.Google Scholar
  15. 15.
    Kantariian, A. D., andDejong, R. N. Familial primary amyloidosis.Neurology 3:399, 1953.PubMedGoogle Scholar
  16. 16.
    Andrede, C. A peculiar form of peripheral neuropathy.Brain 75:408, 1952.PubMedGoogle Scholar
  17. 17.
    Fredericksen, T., Gotzsche, H., Harboe, N., Kiaer, W., andMellemgaard, K. Familial amyloidosis.Am. J. Med. 33:328, 1962.PubMedGoogle Scholar
  18. 18.
    Bero, G. L. Amyloidosis-clinical and pathological manifestations.Ann. Int. Med. 46:931, 1957.PubMedGoogle Scholar
  19. 19.
    Gafni, J., andSohar, E. Rectal biopsy of diagnosis of amyloidosis.Am. J. M. Sc. 240:332, 1960.PubMedGoogle Scholar
  20. 20.
    Blum, A., andSohar, E. Diagnosis of amyloidosis.Lancet 1:721, 1962.PubMedGoogle Scholar
  21. 21.
    Green, P. A., Higgins, J. A., Brown, A. L., Jr., Hoffman, H. N. II, andSommerville, R. L. Amyloidosis.An appraisal of biopsy of small bowel in diagnosis. Gastroenterology 41:452, 1961.Google Scholar
  22. 22.
    Rukavina, J. G. Primary systemic amyloidosis.J. Lancet 83:380, 1963.PubMedGoogle Scholar
  23. 23.
    Stauffer, M. H., Gross, J. B., Foulk, W. T., andDahlin, D. C. Amyloidosis—diagnosis with needle biopsy of liver.Gastroenterology 41:92, 1961.Google Scholar
  24. 24.
    Fentem, P. H., Turnberg, L. A., andWormsley, K. G. Biopsy of the rectum as an aid to the diagnosis of amyloidosis.Brit. M. J. 1:364, 1962.Google Scholar
  25. 25.
    Symposium on Amyloidosis.U.S. Armed Forces M. J. 2:707, 1951. Google Scholar
  26. 26.
    Symmers, W. S. C. Primary amyloidosis; a review.J. Clin. Path. 9:187, 1956.PubMedGoogle Scholar
  27. 27.
    Lindsay, S. The heart in primary systemic amyloidosis.Am. Heart J. 32:419, 1946.Google Scholar
  28. 28.
    Lindeman, R. D., Scheer, R. L., andRaisz, L. G. Renal amyloidosis.Ann. Int. Med. 54:883, 1961.PubMedGoogle Scholar
  29. 29.
    Higgins, W. H., andHiggins, W. H. Jr. Primary amyloidosis.Am. J. M. Sc. 220:610, 1950.PubMedGoogle Scholar
  30. 30.
    Eisen, H. N. Primary systemic amyloidosis.Am. J. Med. 1:144, 1946.Google Scholar
  31. 31.
    Shipps, F. C, andBrannan, D. D X-ray findings in amyloidosis of the stomach.Am. J. Roentgenol. 68:204, 1952.Google Scholar
  32. 32.
    Brady, A., Wertlake, P. T., andLaster, L. Causes of intestinal symptoms in primary amyloidosis.Arch. Int. Med. 113:512, 1964.Google Scholar
  33. 33.
    Codey, R. N. Primary amyloidosis with involvement of the stomach.Am. J. Roentgenol. 70:428, 1953.Google Scholar
  34. 34.
    Golden, A. Primary systemic amyloidosis of the alimentary tract.Arch. Int. Med. 75:413, 1945.Google Scholar
  35. 35.
    Shnider, B. I., andBurka, P. Amyloidosis of stomach simulating gastric carcinoma.Gastroenterology 28:424, 1955.PubMedGoogle Scholar
  36. 36.
    Lindsay, S., andKnorp, W. F. Primary systemic amyloidosis.Arch. Path. 39:315, 1945.Google Scholar
  37. 37.
    Korelitz, B. I., andSpindell, L. N. Gastrointestinal amyloidosis.J. Mt. Sinai Hosp. 23:683, 1956.Google Scholar
  38. 38.
    Stauffer, M. H. Hepatic manifestations in secondary amyloidosis.M. Clin. North America 34:1165, 1950.Google Scholar
  39. 39.
    Levine, R. Amyloid disease of the liver.Am. J. Med. 33:349, 1962.PubMedGoogle Scholar
  40. 40.
    Chambers, R. A., Medd, W. E., andSpencer, H. Primary amyloidosis.Quart. J. Med. 27:207, 1958.PubMedGoogle Scholar
  41. 41.
    Kyle, R. A., andBayrd, E. O. Primary amyloidosis.Arch. Int. Med. 107:344, 1961.Google Scholar
  42. 42.
    Tiber, A. M., Pearlman, A. W. andCohen, S. E. Hepatic function in patients with amyloidosis.Arch. Int. Med. 68:309, 1941.Google Scholar
  43. 43.
    Berns, B., andWolff, H. J. Primary systemic amyloidosis.Gastroenterology 13:67, 1949.Google Scholar
  44. 44.
    Spain, D. M., andRiley, R. L. Jaundice in amyloidosis of liver.Am. J. Clin. Path. 14:284, 1944.Google Scholar
  45. 45.
    Kledner, M. S., Jr., andMagidson, J. Amyloidosis of the liver.Gastroenlerology 23:56, 1955.Google Scholar
  46. 46.
    Zetzel, L. Hepatomegaly with janndice due to primary amyloidosis.Gastroenterology 8:783, 1947.Google Scholar

Copyright information

© Hoeber Medical Division • Harper & Row, Publishers, Incorporated 1966

Authors and Affiliations

  • Robert S. Merrill
    • 1
  1. 1.From the Medical Service of the Veterans Administration HospitalTomah

Personalised recommendations