The American Journal of Digestive Diseases

, Volume 15, Issue 3, pp 247–250 | Cite as

The effect of colchicine on guinea pig intestinal enzyme activity

  • Michael I. Cohen
  • Helen McNamara


The intestinal mucosal reaction to colchicine in guinea pigs as measured by sucrase, maltase, and gamma glutamyl transpeptidase activity is described. There is a significant fall in disaccharidase activity without alteration in the peptidase activity after colchicine administration. This suggests a specific response of the disaccharidase system rather than a generalized toxic mucosal effect of colchicine.


Public Health Enzyme Enzyme Activity Colchicine Peptidase Activity 
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Copyright information

© Hoeber Medical Division • Harper & Row, Publishers, Incorporated 1970

Authors and Affiliations

  • Michael I. Cohen
    • 2
    • 1
  • Helen McNamara
    • 2
    • 1
  1. 1.Department of PediatricsAlbert Einstein College of MedicineBronx
  2. 2.Department of PediatricsMontefiore Hospital and Medical CenterBronx

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