The effect of colchicine on guinea pig intestinal enzyme activity
- 14 Downloads
The intestinal mucosal reaction to colchicine in guinea pigs as measured by sucrase, maltase, and gamma glutamyl transpeptidase activity is described. There is a significant fall in disaccharidase activity without alteration in the peptidase activity after colchicine administration. This suggests a specific response of the disaccharidase system rather than a generalized toxic mucosal effect of colchicine.
KeywordsPublic Health Enzyme Enzyme Activity Colchicine Peptidase Activity
Unable to display preview. Download preview PDF.
- 1.Race TF, Poes IC, Faloon WW: Intestinal malabsorption by oral colchicine.Clin Res 14:480, 1966Google Scholar
- 3.Herbst JJ, Hurwitz R, Sunshine P, Kretchmer, N: Effect of colchicine on cellular turnover and enzymatic activity of intestinal mucosa (Abst). Presented to Society for Pediatric Research Atlantic City, NJ, May 1968Google Scholar
- 5.Cohen MI, Gartner LM, Blumenfeld OO, Arias IM: Gamma glutamyl transpeptidase: Measurement and development in guinea pig small intestine.Ped Res 3:5, 1969Google Scholar
- 8.Rutenberg AM: Personal communication, 1969Google Scholar
- 9.Linstrom C: Personal communication, 1969Google Scholar
- 10.Dahlqvist A: Method for assay of intestinal disaccharidases.Anal Biochem 7:18, 1964Google Scholar
- 11.Malawista SE: Sols, gels, and the mechanism of action of colchicine.J Clin Invest 43:1241, 1964Google Scholar