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Effect of peptides on the uptake of Co57B12 by the guinea pig intestinal mucosa homogenates

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Summary and Conclusions

Over 30 di-, tri-, tetra-, and polypeptides derived from 14 aminoacids were assayed for their enhancing activity upon the uptake of radioactive B12 in the guinea pig intestinal homogenate system. No unequivocal activity of these materials could be demonstrated. The negative results obtained (including those with the use of glutamic acid) do not lend support to the concept that simple low-molecular-weight peptides or amino-acid units play a role in the intestinal absorption of Vitamin B12.

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Authors and Affiliations

  1. From the Gastroenterology Research Laboratory and Section of Gastroenterology, Department of Medicine, New York Medical College-Metropolitan Hospital Medical Center, New York, N. Y.

    Zaida Castro-Curel Ph.D. & George B. Jerzy Glass M.D.

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  1. Zaida Castro-Curel Ph.D.
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  2. George B. Jerzy Glass M.D.
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Supported by Research Grant-in-Aid AM-00068-12 from the National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, U. S. Public Health Service.

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Castro-Curel, Z., Glass, G.B.J. Effect of peptides on the uptake of Co57B12 by the guinea pig intestinal mucosa homogenates. Digest Dis Sci 10, 367–374 (1965). https://doi.org/10.1007/BF02233428

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