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Pancreozymin-“Augmented” triolein test: A preliminary report

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Summary

Forty I131 triolein tests using both blood and fecal radioactivity assays were performed in 37 patients with various diseases associated with steatorrhea and in controls.

Frequent discrepancies were found in triolein test results, as evaluated by blood and fecal radioactivity, as well as discrepancies between results of triolein tests and degree of steatorrhea.

On 28 occasions, therefore, an “augmented” triolein test involving simultaneous intravenous infusion of Pancreozymin or cholecystokinin was performed in this group of patients.

Triolein absorption was improved by stimulation with Pancreozymin or Cecekin in patients with chronic pancreatitis, but not in those with steatorrhea due to intestinal disease, pancreatic ablation, or pancreatic exclusion. This “augmented” triolein test may help to distinguish steatorrhea due to pancreatic insufficiency from other types of steatorrhea, as well as to evaluate the degree of pancreatic secretory reserve.

Increase in intestinal mobility due to administration of pancreozymin or cholecystokinin, when superimposed upon improper mixing of ingested fat with bile and pancreatic secretions in patients with conventional Bilroth II subtotal gastrectomy, results in consistent decrease of triolein absorption.

Further studies to corroborate and extend these preliminary findings are indicated.

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Authors and Affiliations

  1. From the Section of Gastroenterology, Department of Medicine, New York Medical College-Metropolitan Hospital Medical Center, New York, N. Y.

    Moshe Freud M.D., Melvin Weinhouse M.D. & George B. Jerzy Glass M.D.

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  1. Moshe Freud M.D.
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  2. Melvin Weinhouse M.D.
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  3. George B. Jerzy Glass M.D.
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Additional information

Supported by Training Grant TI-AM-5237-02 from the Institute of Arthritis and Metabolic Diseases, U. S. Public Health Service; the Clinical Research Center Grant AM-05576-02 to the Department of Medicine, New York Medical College, from the National Institutes of Health, U. S. Public Health Service; and by Contract U-1373 of the Health Research Council of the City of New York.

Public Health Service Trainees in Gastroenterology.

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Freud, M., Weinhouse, M. & Glass, G.B.J. Pancreozymin-“Augmented” triolein test: A preliminary report. Digest Dis Sci 10, 324–333 (1965). https://doi.org/10.1007/BF02233424

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