The American Journal of Digestive Diseases

, Volume 12, Issue 10, pp 1029–1035 | Cite as

A study of a patient with an external pancreatic fistula

  • H. Schapiro
  • J. B. Ragland
  • R. Sherman
  • L. D. Wruble
Article

Summary

In a man with an external pancreatic fistula, oral alcohol, intravenous secretin, and intrajejunal 0.1 N HCl caused a marked increase in pancreatic exocrine flow. Pitressin and anticholinergic drugs depressed the basal pancreatic flow, while secretin-stimulated flow was only slightly reduced by the anticholinergic drugs.

Keywords

Public Health Alcohol Pitressin Secretin Pancreatic Fistula 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Caraway, W. T. A stable starch substrate for the determination of amylase in serum and other body fluids.Amer J Clin Path 32:97, 1959.Google Scholar
  2. 2.
    Snyder, W. H., andLium, R. Pancreatic fistula.Surg Gynec Obstet 62:57, 1936.Google Scholar
  3. 3.
    Lahey, F. H., andLium, R. Cure of pancreatic fistula by pancreato-jejunostomy.Surg Gynec Obstet 64:79, 1937.Google Scholar
  4. 4.
    Miller, J. M., andWiper, T. B. Physiologic observations on patients with external pancreatic fistula.Ann Surg 120:852, 1944.Google Scholar
  5. 5.
    Newman, E. A., andEisenstein, M. Observations on a patient with pancreatic fistula.Gastroenterology 13:528, 1949.PubMedGoogle Scholar
  6. 6.
    Mahaffey, J. H., andHaynes, B. B., Jr. Observations on pancreatic juice in a case of external fistula in man.Amer Surg 19:174, 1953.Google Scholar
  7. 7.
    Kepes, J. D., Lord, G. A., French, E. E., andVandelinde, R. J. External pancreatic secretion.Gastroenterology 31:190, 1956.PubMedGoogle Scholar
  8. 8.
    Bartlett, L. C, andThorlakson, P. H. T. The etiology and technique of surgical management of pancreatic fistula.Surg Gynec Obstet 102:413, 1956.PubMedGoogle Scholar
  9. 9.
    Sinclair, I. S. R. Observations on a case of external pancreatic fistula in man.Brit J Surg 44:250, 1956.PubMedGoogle Scholar
  10. 10.
    Hirota, M. Post-gastrectomy pancreatic secretion: Experimental observation on a case of the external pancreatic fistula in man.Yokohama Med Bull 9:187, 1958.PubMedGoogle Scholar
  11. 11.
    Anderson, M. D., Mehn, W. H., andMethod, H. C. Physiologic observations upon a partial pancreatic fistula following gastrectomy.Amer J Surg 97:260, 1959.PubMedGoogle Scholar
  12. 12.
    Elmslie, R. G., White, T. T., andMagee, D. F. Observation on pancreatic function in eight patients with controlled pancreatic listulas.Ann Surg 160:937, 1964.PubMedGoogle Scholar
  13. 13.
    Comfort, M. W., andPriestley, J. T. External pancreatic fistula: Report of case with physiologic observations and surgical considerations.Mayo Clin Proc 18:409, 1943.Google Scholar
  14. 14.
    Fleig, C. Intervention d'un processus humoral dans la secretion pancreatique par action de l'alcool sur la muqueuse intestinale.C R Soc Biol 55:1277, 1903.Google Scholar
  15. 15.
    Gizelt, A. Über den Einfluss des Alkohols auf die sekretorische Tätigkeit und die Verdauungsfermente der Bauchspeicheldr üse.Pflugers Arch Ges Physiol 111:620, 1906.Google Scholar
  16. 16.
    Walton, B. W., Schapiro, H., andWoodward, E. R. The effect of alcohol and histamine on pancreatic secretion.Amer Surg 28:443, 1962.Google Scholar
  17. 17.
    Hong, S. S., Chin, D. S., andHur, K. B. Influences of hexamethonium and some dietary factors on human pancreatic and bile secretion.J Appl Physiol 16:810, 1961.PubMedGoogle Scholar
  18. 18.
    Dreiling, D. A., and Janowitz, H. D. The measurement of pancreatic secretory function. InCIBA Foundation Symposium on the Exocrine Pancreas: Normal and Abnormal Functions, 1961, Proceedings. Churchill, London, 1962, pp. 225–240.Google Scholar
  19. 19.
    Hartley, R. C, Gambill, E. E., andSummerskill, W. H. J. Pancreatic volume and bicarbonate output with augmented doses of secretin.Gastroenterology 48:312, 1965.PubMedGoogle Scholar
  20. 20.
    Sarles, H., Prezlin, G., Souville, C, andFigarella, C. Effect of increasing doses of secretin on the human pancreas.Maximum secretion capacity. Rev Franc Etud Clin Biol 11: 294, 1966.Google Scholar
  21. 21.
    McCauchan, J. M., Sinner, B. L., andSullivan, C. J. The external secretory function of the human pancreas.Arch Int Med 61:739, 1938.Google Scholar
  22. 22.
    Miller, J. M., andGinsberg, M. Physiologic observations on a patient with an external pancreatic fistula.Arch Surg 61:346, 1950.PubMedGoogle Scholar
  23. 23.
    Villaret, M., andJustin-Besancon, L. Etude clinique et physiologique d'une fistule pancreatique.Arch Mal Apper Dig 15: 751, 1925.Google Scholar
  24. 24.
    Preshaw, R. M., Cooke, A. R., andGrossman, M. I. Quantitative aspects of response of canine pancreas to duodenal acidification.Amer J Physiol 210:629, 1966.PubMedGoogle Scholar
  25. 25.
    Perks, A. M., Schapiro, H., andWoodward, E. R. The influence of antidiuretic hormone on pancreatic exocrine secretion.Acta Endocr 45:340, 1964.PubMedGoogle Scholar
  26. 26.
    Comfort, M. W., Osterbug, A. E., andPriestley, J. T. External pancreatic fistula: Report of a case with physiologic observations.Amer J Dig Dis 10:7, 1943.Google Scholar
  27. 27.
    Howard, J. M., Evans, S. S., andJames, C. L. Effects of Banthine on the external pancreatic secretion in man.Ann Surg 135:91, 1952.PubMedGoogle Scholar
  28. 28.
    Rumore, P. C, Olander, G. A., andPuestow, C. B. Excretion of antibiotics, dyes and radioactive substances through external pancreatic fistula.Surg 34:735, 1953.Google Scholar

Copyright information

© Hoeber Medical Division • Harper & Row, Publishers, Incorporated 1967

Authors and Affiliations

  • H. Schapiro
    • 1
  • J. B. Ragland
    • 1
  • R. Sherman
    • 1
  • L. D. Wruble
    • 1
  1. 1.From the Departments of Anatory and Biochemistry, School of Basic Medical Science, and Departments of Surgery and Medicine (Division of Gastroenterology)University of Tennessee Medical UnitsMemphis

Personalised recommendations