Effect of local gastric trauma on gastric response to histamine stimulation
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The effect of injury on the gastric mucosal response to histamine stimulation has been investigated in dogs by 2 technics. (1) Exposing the intact surface of the stomach to several kinds of trauma, e.g., friction, heat, salt, alcohol, and formalin. It was found that the surface of the traumatized area, in each instance, was coated with an alkaline surface of pH 7–9. This alkalinization of the surface after trauma was not affected by submucosal infiltration of local anesthetic. (2) Total gastric pouches in stimulated and unstimulated dogs were filled with ethanol (50% and 70%). In stimulated animals, the gastric secretory output of volume and acid were considerably reduced. In nonstimulated animals, there was a transient rise in the volume of gastric juice after ethanol instillation followed by a reduced output. However, the concentration of acid was low after ethanol administration.
It is suggested that part of the explanation for these findings lies in the effect of injury on the secreting epithelium, this effect being physiologic and not associated with gross structural damage to the secreting cells.
KeywordsHistamine Gastric Juice Local Anesthetic Structural Damage Secreting Cell
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