Summary
Neomycin sulfate, at doses of 250 mg./kg. or 2 gm./kg., was instilled intragastrically, in male Fisher-strain rats daily for 21 days. Pair-fed controls received an equal amount of saline intragastrically for an equal period. After 3 weeks of treatment animals were tested by our modification of the Cori method to assess the absorption of xylose, glucose, and a mixture of xylose and glucose. Rats receiving neomycin at both doses demonstrated an enhanced absorption of glucose. A significant reduction in the absorption of xylose was noted in animals treated with 2 gm./kg. of neomycin. When glucose and xylose were administered together to rats receiving 2 gm./kg. of neomycin, a significant reduction in the absorption of xylose and an enhancement in the absorption of glucose was observed.
Histologic examination revealed no constant alterations in the appearance of the small intestinal mucosa of the neomycin-treated rats.
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Supported in part by the Georgetown Univerity Medical School General Research Fund and by Grant AM 07125 from the U. S. Public Health Service.
The technical assistance of Paula Meyer, James Robbins, and Joel Taubin is gratefully acknowledged, and we would like to thank Dr. Robert Damiano, The Upjohn Company, Kalamazoo, Mich., for supplying neomycin sulfate.
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Small, M.D., Folen, V., Abrams, G. et al. High doses of neomycin sulfate and the absorption of glucose and xylose from the rat small intestine. Digest Dis Sci 11, 923–929 (1966). https://doi.org/10.1007/BF02233080
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DOI: https://doi.org/10.1007/BF02233080