The American Journal of Digestive Diseases

, Volume 13, Issue 11, pp 974–986 | Cite as

Enzyme histochemistry of chronic atrophic gastritis

  • Howard I. Siegel
  • Robert Lev
  • George B. Jerzy Glass


In early chronic atrophic gastritis there appear patches of altered surface epithelium having the morphologic and histochemical characteristics of a regenerating mucosa. This suggests that prior injury to the neck and crypt areas of the normal gastric surface epithelium may have pathogenetic significance in the onset of this disease.

The appearance of numerous enzymes and acidic glycoprotein in intestinalized mucosa within the stomach suggest that this new epithelium has acquired properties not found in normal gastric surface epithelium.

The decreased numbers of chief and parietal cells in chronic atrophic gastritis cannot be explained by accelerated destruction of these cells or by excess shedding of them into the gastric lumen.


Public Health Enzyme Gastritis Intestinalized Mucosa Parietal Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Hoeber Medical Division • Harper & Row, Publishers, Incorporated 1968

Authors and Affiliations

  • Howard I. Siegel
    • 1
  • Robert Lev
    • 1
  • George B. Jerzy Glass
    • 1
  1. 1.From the Section of Gastroenterology and Gastroenterology Research Laboratory, Department of Medicine, and the Department of PathologyNew York Medical CollegeNew York

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