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The American Journal of Digestive Diseases

, Volume 13, Issue 11, pp 952–958 | Cite as

Comparison of histamine and carbachol effect on vitamin B12 absorption in man

  • T. Kanaghinis
  • A. Papayannis
  • D. Ikkos
  • P. Gatsou
Article
  • 27 Downloads

Summary

The effect of injections of histamine on the absorption of radiocobalamin was studied by means of the Schilling test in 61 patients. Histamine significantly increased the absorption of Vitamin B12 from the gut. The effects of histamine and carbachol were compared in 31 subjects, and both substances were equally effective in increasing Vitamin B12 absorption. The results suggest that in addition to stimulating the secretion of I.F., histamine may increase the absorption of Vitamin B12 by another mechanism not mediated by this factor, such as a direct action on the small bowel.

Keywords

Public Health Histamine Small Bowel Direct Action Carbachol 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Chow, B. F. Vitamin B 12 and Aging. Nutrition Symposium (Ser. 9). National Vitamin Foundation, Inc., 1954, p. 59.Google Scholar
  2. 2.
    Glass, G. B. J., andCastro-Curel, Z. “Assay of I.F. Activity on Guinea Pig Intestinal Mucosa Homogenate.” InProceedings of the 9th Congress of the European Society of Haematology (Vol. 2). Karger, Basel, 1963, p. 1470.Google Scholar
  3. 3.
    Sullivan, L. W., Herbert, V., andCastle, W. B. In vitro assay of human intrinsic factor.J Clin Invest 42:1443, 1963.PubMedGoogle Scholar
  4. 4.
    Ardeman, S., Chanarin, I., andDoyle, J. C. Studies on secretion of gastric I.F. in man.Brit Med J 2:600, 1964.Google Scholar
  5. 5.
    Ardeman, S., andChanarin, I. Assay of I.F. in the diagnosis of Addisonian pernicious anemia.Brit J Haemat 11:305, 1965.PubMedGoogle Scholar
  6. 6.
    Ardeman, S., andChanarin, I. Stimulation of gastric I.F. secretion.Brit Med J 1:1417, 1965.Google Scholar
  7. 7.
    Ardeman, S., andChanarin, I. Intrinsic factor secretion in gastric atrophy.Gut 7:99, 1966.PubMedGoogle Scholar
  8. 8.
    Clark, C. G., June, C. V., Murray, J. G., andStephen, G. O. Mode of action of histamine in causing gastric secretion in man.Gut 5:527, 1964.Google Scholar
  9. 9.
    Glass, G. B. J. Gastric I.F. and its function in the metabolism of Vitamin B12.Physiol Rev 43:620, 1963.Google Scholar
  10. 10.
    Herbert, V. Intrinsic factor.Gastroenterology 49:218, 1965.PubMedGoogle Scholar
  11. 11.
    Irvine, W. J. Effect of gastrin I and II on secretion of I.F.Lancet 1:736, 1965.CrossRefGoogle Scholar
  12. 12.
    Rødbro, P., Christiansen, P. M. andSchwartz, M. Intrinsic factor secretion in stomach diseases.Lancet 2:1200, 1965.CrossRefPubMedGoogle Scholar
  13. 13.
    Rødbro, P., andChristiansen, P. M. Quantitative determination of gastric I.F. after large histamine doses in healthy persons.Scand J Clin Lab Invest 19:187, 1967.Google Scholar
  14. 14.
    Rødbro P., andChristiansen, P. M. Quantitative estimation of parietal cell secretory function in man.Scand J Gastoent 1:292, 1965.Google Scholar
  15. 15.
    Taylor, K. B., andTaylor, W. H. The effect of oral histamine on the absorption of radioactive Vitamin B12 from the gastrointestinal tract.Clin Sci 16:401, 1957.PubMedGoogle Scholar
  16. 16.
    Callender, S. T., Witts, L. J., Allison, P. R., andGunning, A. Some metabolic and haematological effects of oesophagojejunostomy with bypass of the stomach.Gut 2:150, 1961.PubMedGoogle Scholar
  17. 17.
    Mollin, D. L., andBaker, S. J. The absorption and excretion of Vitamin B12 in man.Biochem Soc Sympos 13:52, 1955.Google Scholar
  18. 18.
    Jeffries, G. H., andSleisenger, M. H. The pharmacology of I.F. secretion in man.Gastroenterology 48:444, 1965.PubMedGoogle Scholar
  19. 19.
    Callender, S. T., andEvans, J. R. The urinary excretion of labelled Vitamin B12.Clin Sci 14:295, 1955.PubMedGoogle Scholar
  20. 20.
    Bonnier, G., andTedin, O. Biologisk variation analys. Svenska Bokforlaget, Stockholm, 1940.Google Scholar
  21. 21.
    Dotevall, G., andWalan, A. Gastric secretion of acid after intravenous infusion of histamine in large doses.Acta Med Scand 181:439, 1967.PubMedGoogle Scholar

Copyright information

© Hoeber Medical Division • Harper & Row, Publishers, Incorporated 1968

Authors and Affiliations

  • T. Kanaghinis
    • 1
  • A. Papayannis
    • 1
  • D. Ikkos
    • 1
  • P. Gatsou
    • 1
  1. 1.From the Second Medical Unit and the Radioisotope LaboratoryEvangelismos HospitalAthens

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