Amphotericin B given parenterally is nephrotoxic. The drug is poorly absorbed from the normal gastrointestinal tract and has no side effects. We wished to determine whether oral Amphotericin B is absorbed from the gastrointestinal tract of patients with intestinal ulcerations, since this drug might occasionally be needed for candidiasis after prolonged antibiotic therapy. Patients hospitalized for ulcerative colitis or enteritis were given 100 mg Amphotericin B suspension, 4 times daily for 5 days. After a 2-day rest period, they received 200 mg, 4 times daily, and finally 500 mg, 4 times daily. Antifungal activity of serum; urinary pH, specific gravity, protein and sediment; BUN and potassium were determined before, during and at the end of each test period; creatinine clearance and PSP, at the start and at the end of each test period. No kidney or electrolyte disturbance and only little absorption of the antifungal agent was found. No significant subjective symptoms, such as abdominal pain, nausea, vomiting, heartburn or headache were noted.
Gastrointestinal Tract Specific Gravity Ulcerative Colitis Amphotericin Antifungal Activity
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1.From The Hektoen Institute for Medical Research and the Department of Gastroenterology of Cook County Hospital, and the Departments of Internal Medicine, Stritch School of MedicineLoyola UniversityUSA
2.College of MedicineUniversity of IllinoisChicago