Abstract
Twenty intestinal biopsy specimens from Jamaican subjects who did not have evidence of gastrointestinal disease were examined under the dissecting microscope and histologically. The appearances were normal in all 20. The most common finding was a mixture of finger- and leaf-shaped villi. Histologically, the biopsy specimens were also normal, consisting of long slender villi with short crypts and very few inflammatory cells. The crypt length; adult crypt cell ratio, mitotic index and turnover time were normal. These findings indicate that the set of circumstances causing and perpetuating the abnormalities seen in the jejunal biopsies of subjects living in the tropics, do not exist in Jamaica, and that the small intestinal villous appearance and mucosal dynamics in the healthy Jamaican Negro are similar to those of Europeans and North Americans.
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References
Leblond CP, Walker BE: Renewal of cell populations. Physiol Rev 36:255–276, 1956
Creamer B, Shorter RG, Bamforth G: Gut 2:110–118, 1961
Rubin CE, Dobbins WO: Peroral biopsy of the small intestine. Gastroenterology 49:676–697, 1965
Creamer B: The turnover of the epithelium of the small intestine. Br Med Bull 23:226–230, 1967
Sprinz H: Morphological response of intestinal mucosa to enteric bacteria and its implication for sprue and Asiatic cholera. Fed Proc 21:57, 1962
Baker SJ, Ignatius M, Mathan UI, et al: In intestinal biopsy, Ciba Foundation Study Group, No. 14. Churchill, London, 1962, p 88
Sprinz H, Sribhibhadh R, Gangarosa EJ, et al: Biopsy of small bowel of Thai people. With special reference to recovery from Asiatic cholera and to an intestinal malabsorption syndrome. Am J Clin Pathol 38:43–51, 1962
Russell PK, Aziz MA, Ahmed N, et al: Enteritis and gastritis in young asymptomatic Pakistani men. Am J Dig Dis 11:296–306, 1966
Lindenbaum J, Alam AKMJ, Kent TH: Subclinical small intestinal disease in East Pakistan. Br Med J 2:1616–1619, 1966
Klipstein FA, Samloff IM, Schenk EA: Tropical sprue in Haiti. Ann Intern Med 64:575–594, 1966
Lindenbaum J, Kent TH, Sprinz H: Malabsorption and jejunitis in American Peace Corps volunteers in Pakistan. Ann Intern Med, 65:1201–1209, 1966
Lindenbaum J, Gerson CD, Kent TH: Recovery of small intestinal structure and function after residence in the tropics. Ann Intern Med 74:218–222, 1971
Crosby WH, Kugler HW: Intraluminal biopsy of the small intestine. Am J Dig Dis 2:236, 1957
Bayless TM, Swanson VL, Wheby MS: Jejunal histology and clinical status in tropical sprue and other chronic diarrhoeal disorders. Am J Clin Nutr 24:112–116, 1971
Lindenbaum J: Small intestinal dysfunction in Pakistanis and Americans resident in Pakistan. Am J Clin Nutr 21:1023–1029, 1968
Stanfield JP, Hutt MSR, Tunnicliffe R: Intestinal biopsy in kwashiorkor. Lancet 2:519–523, 1965
Tandon BN, Saraya AK, Ramchandran K, et al: Relationship of anaemia and hypoproteinaemia to the functional and structural changes in the small bowel in hookworm disease. Gut 10:360–365, 1969
Tandon BN, Kohli RK, Saraya AK, et al: Role of parasites in the pathogenesis of intestinal malabsorption in hookworm disease. Gut 10:293–298, 1969
Sheehy TW, Artenstein MS, Green RW: Small intestinal mucosa in certain viral diseases. JAMA 190:1023–1028, 1964
Lindenbaum J: Malabsorption during and after recovery from acute intestinal infection. Br Med J 2:326–329, 1965
Klipstein FA: Tropical sprue-an iceberg disease? Ann Intern Med 66:622–623, 1967
Troncale FJ, Keusch GT, Miller LH, et al: Normal absorption in Thai subjects with non-specific jejunal abnormalities Br Med J 4:578–580, 1967
Swanson VL, Thomassen RW: Pathology of the jejunal mucosa in tropical sprue. Am J Pathol 46:511–550, 1965
Creamer B: Dynamics of the mucosa of the small intestine in idiopathic steatorrhoea. Gut 3:295–300, 1962
Bertalanffy FD, Nagy KP: Mitotic activity and cell renewal rate of the epithelial cells of human duodenum. Acta Anat 45:362, 1961
MacDonald WC, Trier JS, Everett NW: Cell proliferation and migration in the stomach, duodenum and rectum of man: radioautographic studies. Gastroenterology 46:405–417, 1964
Creamer B: Malignancy and the small intestinal mucosa. Br Med J 2:1435–1436, 1964
Baker SJ, Mathan UI, Cherian V: The nature of the villi in the small intestine of the rat. Lancet I:860, 1963
Creamer B: Small intestinal mucosa dynamics and the environment. Br Med J 2:1373–1375, 1964
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Da Costa, L.R. Small intestinal villous pattern and mucosal dynamics in healthy Jamaicans. Digest Dis Sci 17, 105–110 (1972). https://doi.org/10.1007/BF02232729
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DOI: https://doi.org/10.1007/BF02232729