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The American Journal of Digestive Diseases

, Volume 17, Issue 2, pp 105–110 | Cite as

Small intestinal villous pattern and mucosal dynamics in healthy Jamaicans

  • L. R. Da Costa
Article

Abstract

Twenty intestinal biopsy specimens from Jamaican subjects who did not have evidence of gastrointestinal disease were examined under the dissecting microscope and histologically. The appearances were normal in all 20. The most common finding was a mixture of finger- and leaf-shaped villi. Histologically, the biopsy specimens were also normal, consisting of long slender villi with short crypts and very few inflammatory cells. The crypt length; adult crypt cell ratio, mitotic index and turnover time were normal. These findings indicate that the set of circumstances causing and perpetuating the abnormalities seen in the jejunal biopsies of subjects living in the tropics, do not exist in Jamaica, and that the small intestinal villous appearance and mucosal dynamics in the healthy Jamaican Negro are similar to those of Europeans and North Americans.

Keywords

Public Health Inflammatory Cell Biopsy Specimen Mitotic Index Common Finding 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Leblond CP, Walker BE: Renewal of cell populations. Physiol Rev 36:255–276, 1956Google Scholar
  2. 2.
    Creamer B, Shorter RG, Bamforth G: Gut 2:110–118, 1961Google Scholar
  3. 3.
    Rubin CE, Dobbins WO: Peroral biopsy of the small intestine. Gastroenterology 49:676–697, 1965Google Scholar
  4. 4.
    Creamer B: The turnover of the epithelium of the small intestine. Br Med Bull 23:226–230, 1967Google Scholar
  5. 5.
    Sprinz H: Morphological response of intestinal mucosa to enteric bacteria and its implication for sprue and Asiatic cholera. Fed Proc 21:57, 1962Google Scholar
  6. 6.
    Baker SJ, Ignatius M, Mathan UI, et al: In intestinal biopsy, Ciba Foundation Study Group, No. 14. Churchill, London, 1962, p 88Google Scholar
  7. 7.
    Sprinz H, Sribhibhadh R, Gangarosa EJ, et al: Biopsy of small bowel of Thai people. With special reference to recovery from Asiatic cholera and to an intestinal malabsorption syndrome. Am J Clin Pathol 38:43–51, 1962Google Scholar
  8. 8.
    Russell PK, Aziz MA, Ahmed N, et al: Enteritis and gastritis in young asymptomatic Pakistani men. Am J Dig Dis 11:296–306, 1966Google Scholar
  9. 9.
    Lindenbaum J, Alam AKMJ, Kent TH: Subclinical small intestinal disease in East Pakistan. Br Med J 2:1616–1619, 1966Google Scholar
  10. 10.
    Klipstein FA, Samloff IM, Schenk EA: Tropical sprue in Haiti. Ann Intern Med 64:575–594, 1966Google Scholar
  11. 11.
    Lindenbaum J, Kent TH, Sprinz H: Malabsorption and jejunitis in American Peace Corps volunteers in Pakistan. Ann Intern Med, 65:1201–1209, 1966Google Scholar
  12. 12.
    Lindenbaum J, Gerson CD, Kent TH: Recovery of small intestinal structure and function after residence in the tropics. Ann Intern Med 74:218–222, 1971Google Scholar
  13. 13.
    Crosby WH, Kugler HW: Intraluminal biopsy of the small intestine. Am J Dig Dis 2:236, 1957Google Scholar
  14. 14.
    Bayless TM, Swanson VL, Wheby MS: Jejunal histology and clinical status in tropical sprue and other chronic diarrhoeal disorders. Am J Clin Nutr 24:112–116, 1971Google Scholar
  15. 15.
    Lindenbaum J: Small intestinal dysfunction in Pakistanis and Americans resident in Pakistan. Am J Clin Nutr 21:1023–1029, 1968Google Scholar
  16. 16.
    Stanfield JP, Hutt MSR, Tunnicliffe R: Intestinal biopsy in kwashiorkor. Lancet 2:519–523, 1965Google Scholar
  17. 17.
    Tandon BN, Saraya AK, Ramchandran K, et al: Relationship of anaemia and hypoproteinaemia to the functional and structural changes in the small bowel in hookworm disease. Gut 10:360–365, 1969Google Scholar
  18. 18.
    Tandon BN, Kohli RK, Saraya AK, et al: Role of parasites in the pathogenesis of intestinal malabsorption in hookworm disease. Gut 10:293–298, 1969Google Scholar
  19. 19.
    Sheehy TW, Artenstein MS, Green RW: Small intestinal mucosa in certain viral diseases. JAMA 190:1023–1028, 1964Google Scholar
  20. 20.
    Lindenbaum J: Malabsorption during and after recovery from acute intestinal infection. Br Med J 2:326–329, 1965Google Scholar
  21. 21.
    Klipstein FA: Tropical sprue-an iceberg disease? Ann Intern Med 66:622–623, 1967Google Scholar
  22. 22.
    Troncale FJ, Keusch GT, Miller LH, et al: Normal absorption in Thai subjects with non-specific jejunal abnormalities Br Med J 4:578–580, 1967Google Scholar
  23. 23.
    Swanson VL, Thomassen RW: Pathology of the jejunal mucosa in tropical sprue. Am J Pathol 46:511–550, 1965Google Scholar
  24. 24.
    Creamer B: Dynamics of the mucosa of the small intestine in idiopathic steatorrhoea. Gut 3:295–300, 1962Google Scholar
  25. 25.
    Bertalanffy FD, Nagy KP: Mitotic activity and cell renewal rate of the epithelial cells of human duodenum. Acta Anat 45:362, 1961Google Scholar
  26. 26.
    MacDonald WC, Trier JS, Everett NW: Cell proliferation and migration in the stomach, duodenum and rectum of man: radioautographic studies. Gastroenterology 46:405–417, 1964Google Scholar
  27. 27.
    Creamer B: Malignancy and the small intestinal mucosa. Br Med J 2:1435–1436, 1964Google Scholar
  28. 28.
    Baker SJ, Mathan UI, Cherian V: The nature of the villi in the small intestine of the rat. Lancet I:860, 1963Google Scholar
  29. 29.
    Creamer B: Small intestinal mucosa dynamics and the environment. Br Med J 2:1373–1375, 1964Google Scholar

Copyright information

© Harper & Row, Publishers, Incorporated 1972

Authors and Affiliations

  • L. R. Da Costa
    • 1
  1. 1.From the Department of Medicine and the Gastrointestinal LaboratoryUniversity of the West Indies, MonaKingstonJamaica

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