The effect of certain tranquilizers on intrabiliary pressure of cholecystectomized dogs

  • R. G. Bianchi
  • R. L. Craig


All transquilizers studied by this procedure were found to be capable of causing increased intrabiliary pressure. The doses required to do this were variable. It is known that chlorpromazine in a therapeutic range in humans will occasionally produce jaundice whereas this has not occurred with therapeutic doses of SC-7105. Two clinical studies, one by McHardy11 and another by Shay12 showed that Dartal in therapeutic doses in 27 patients did not alter the circulating blood elements, serum bilirubin, alkaline phosphatase, bromsulphalein excretion, total serum protein, and albumin-globulin ratio. Schaffner and associates13 have described the differences between cholestasis and cholangiolitis, defining the former as interference with bile flow after its formation by the liver cells. Increased sphincter tone and subsequent increases in intrabiliary pressure could contribute to cholestasis. Whether or not the occurrence of jaundice can be correlated with the quantitative changes in intrabiliary pressure caused by different doses of a tranquilizing agent cannot be determined until a wider range of drugs are studied, but it is suggested that the procedure employed in our study might be helpful in determining this potential.


Alkaline Phosphatase Bilirubin Therapeutic Dose Cholestasis Chlorpromazine 
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Copyright information

© Paul B. Hoeber, Inc., Medical Division of Harper & Brothers 1960

Authors and Affiliations

  • R. G. Bianchi
    • 1
    • 2
  • R. L. Craig
    • 1
    • 2
  1. 1.From the Division of Biological ResearchG. D. Searle and CompanyChicago
  2. 2.Department of SurgeryNorthwestern Medical SchoolChicago

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