Intestinal lactase deficiency and diarrhea in adults

  • Arthur P. Klotz


Two cases of adult lactose intolerance are reported. The absence and severe deficiency of the enzyme B-galactosidase resulting in the syndrome was confirmed by both histochemical staining and paper chromatography.

Methods to determine intestinal enzyme activity by peroral biopsy open a new avenue of investigation of absorption in the gastrointestinal tract and of patients with unexplained diarrhea.

Such cases narrow the concept of food “allergies” often loosely employed for conditions unrelated to immune phenomena.


Public Health Enzyme Chromatography Enzyme Activity Diarrhea 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Holzel, A., Schwarz, V., andSutcliffe, K. W. Defective lactose absorption causing malnutrition in infancy.Lancet 1: 1126, 1959.CrossRefPubMedGoogle Scholar
  2. 2.
    Darling, S., Mortensen, O., andSøndergaard, G. Lactosuria and aminoaciduria in infancy.Acta paediat. 49:281, 1960.Google Scholar
  3. 3.
    Rutenburg, A. M., Rutenburg, S. H., Monis, B., Teagle, R., andSeligman, A. M. Histochemical demonstration of B-d-galactosidase in the rat.J. Histochem. 6:122, 1958.Google Scholar
  4. 4.
    Seligman, A. M., Tsou, K. C, Rutenburg, S. H., andCohen, R. B. Histochemical demonstration of B-d-glucuronidase with a synthetic substrate.J. Histochem. 2:209, 1954.Google Scholar
  5. 5.
    Pearse, A. G. E. Histochemistry, Theoretical and Applied (ed. 2), Churchill, London, 1960.Google Scholar
  6. 6.
    Anderson, C. M., Messer, M., Townley, R. R. W., andFreeman, M. Intestinal sucrase and isomaltase deficiency in two siblings.Pediatrics 31:1003, 1963.PubMedGoogle Scholar
  7. 7.
    Haworth, J. C, andMacDonald, M. S. Reducing sugars in the urine and blood of premature babies.Arch. Dis. Childhood 32: 417, 1957.Google Scholar
  8. 8.
    Froesch, E. R., Prader, A., Labhart, A., Stuber, H. W., andWolf, H. P. Die hereditäre Fructoseintoleranz, eine bisher nicht bekannte kongenitale Stoffwechselstarung.Schweiz. med. Wchnschr. 87:1168, 1957.Google Scholar
  9. 9.
    Froesch, E. R., Prader, A., Wolf, H. P., andLabhart, A. Die hereditäre Fructoseintoleranz.Helvet. paediat. acta 14:99, 1959.PubMedGoogle Scholar
  10. 10.
    Dormandy, T. L., andPorter, R. J. Familial fructose and galactose intolerance.Lancet 1:1189, 1961.CrossRefPubMedGoogle Scholar
  11. 11.
    Auricchio, S., Rubino, A., Landolt, M., Semenza, G., andPrader, A. Isolated intestinal lactose deficiency in the adult.Lancet 2:324, 1963.CrossRefGoogle Scholar
  12. 12.
    Jensen, P. E. Intolerance of cane sugar as a sequel of an enzyme deficiency.Acta paediat. 57:227, 1962.Google Scholar
  13. 13.
    Auricchio, S., Dahlquist, A., Murset, G., andParker, A. Isomaltose intolerance causing decreased ability to utilize dietary starch.J. Pediat. 62:165, 1963.PubMedGoogle Scholar
  14. 14.
    Weijers, H. A., Van De Kamer, J. H., Dicke, W. K., andIjsseling, J. Diarrhea caused by deficiency of sugar splitting enzymes.I. Acta paediat. 50:55, 1961.Google Scholar

Copyright information

© Hoeber Medical Division • Harper & Row, Publishers, Incorporated 1964

Authors and Affiliations

  • Arthur P. Klotz
    • 1
  1. 1.From the University of Kansas Medical CenterKansas City

Personalised recommendations