Primary neoplasms of the liver: The possibility of biochemical diagnosis

  • António Saragoça
  • Brito Barros
  • Carlos Santos Soares


1. In 168 necropsies performed during a period of less than 3 years, 6 cases of primary carcinoma of the liver were found, an incidence of 3.57%. Another case was proved by needle biopsy, but autopsy was not obtained. Six of the 7 carcinomas were diagnosed during the life of the patients concerned.

2. Clinical diagnosis was established upon a history of progressive and rapid general deterioration of health, with anorexia and marked emaciation accompanied by painful nodular hepatomegaly and fever, and later by moderate jaundice and serosanguineous ascitic effusion.

3. The disproportion between the slightly elevated values of serum bilirubin and the high alkaline phosphatase activity, together with an increase of the transaminase levels, were the most important laboratory data, allowing the diagnosis of expanding “space-occupying lesion” (though not specifying its precise nature).

The practical application of these criteria to diagnosis may be rewarded with an increase in “in-vivo ” diagnosis of neoplasms of the liver.


Carcinoma Alkaline Phosphatase Bilirubin Phosphatase Activity Needle Biopsy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Hoeber Medical Division • Harper & Row, Publishers, Incorporated 1964

Authors and Affiliations

  • António Saragoça
    • 1
  • Brito Barros
    • 1
  • Carlos Santos Soares
    • 1
  1. 1.From the Clínica Universitária de Propedeutica MédicaLisbonPortugal

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