Primary neoplasms of the liver: The possibility of biochemical diagnosis
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1. In 168 necropsies performed during a period of less than 3 years, 6 cases of primary carcinoma of the liver were found, an incidence of 3.57%. Another case was proved by needle biopsy, but autopsy was not obtained. Six of the 7 carcinomas were diagnosed during the life of the patients concerned.
2. Clinical diagnosis was established upon a history of progressive and rapid general deterioration of health, with anorexia and marked emaciation accompanied by painful nodular hepatomegaly and fever, and later by moderate jaundice and serosanguineous ascitic effusion.
3. The disproportion between the slightly elevated values of serum bilirubin and the high alkaline phosphatase activity, together with an increase of the transaminase levels, were the most important laboratory data, allowing the diagnosis of expanding “space-occupying lesion” (though not specifying its precise nature).
The practical application of these criteria to diagnosis may be rewarded with an increase in “in-vivo ” diagnosis of neoplasms of the liver.
KeywordsCarcinoma Alkaline Phosphatase Bilirubin Phosphatase Activity Needle Biopsy
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