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Identification of the drug Darvon and its metabolites in the urine of a comatose patient using a gas chromatograph-mass. Spectrometer-computer system

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  • Chimica, Biochimica, Biophysica
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Zusammenfassung

Mit Hilfe von hoch- und niederauflösender Massenspektroskopie sowie Daten eines Gas-chromatograph-Massenspektrometer-Computer-Systems wurden die Droge Darvon3 sowie eine Reihe ihrer Metaboliten im Harn eines Überdosispatienten nachgewiesen.

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Authors and Affiliations

  1. Department of Chemistry, Massachusetts Institute of Technology, 02139, Cambridge, Massachusetts, USA

    J. R. Althaus, K. Biemann, J. Biller, P. F. Donaghue, D. A. Evans, H. -J. Förster, H. S. Hertz, C. E. Hignite, R. C. Murphy, G. Preti & V. Reinhold

Authors
  1. J. R. Althaus
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  2. K. Biemann
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  3. J. Biller
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  4. P. F. Donaghue
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  5. D. A. Evans
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  6. H. -J. Förster
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  7. H. S. Hertz
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  8. C. E. Hignite
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  9. R. C. Murphy
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  10. G. Preti
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  11. V. Reinhold
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Additional information

This publication describes the identification of a drug causing coma in a patient. The drug was identified by analysis of the patient's urine performed at the NIH sponsored Special Research Resource Facility for Mass Spectrometry at M.I.T., under emergency conditions. Most of the experiments, measurements and interpretation reported had to be made within 1 day, thus requiring the simultaneous efforts of many members of M.I.T.'s massspectrometry group.

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Althaus, J.R., Biemann, K., Biller, J. et al. Identification of the drug Darvon and its metabolites in the urine of a comatose patient using a gas chromatograph-mass. Spectrometer-computer system. Experientia 26, 714–717 (1970). https://doi.org/10.1007/BF02232500

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  • DOI: https://doi.org/10.1007/BF02232500

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